Diurnal variation in harbour porpoise detection – potential implications for management

Peer reviewedPublisher PD

Time dependent spectral modeling of Markarian 421 during a violent outburst in 2010

We present the results of extensive modeling of the spectral energy distributions (SEDs) of the closest blazar (z=0.031) Markarian 421 (Mrk 421) during a giant outburst in February 2010. The source underwent rapid flux variations in both X-rays and very high energy (VHE) gamma-rays as it evolved from a low-flux state on 2010 February 13-15 to a high-flux state on 2010 February 17. During this period, the source exhibited significant spectral hardening from X-rays to VHE gamma-rays while exhibiting a "harder when brighter" behavior in these energy bands. We reproduce the broadband SED using a time-dependent multi-zone leptonic jet model with radiation feedback. We find that an injection of the leptonic particle population with a single power-law energy distribution at shock fronts followed by energy losses in an inhomogeneous emission region is suitable for explaining the evolution of Mrk 421 from low- to high-flux state in February 2010. The spectral states are successfully reproduced by a combination of a few key physical parameters, such as the maximum $\&$ minimum cutoffs and power-law slope of the electron injection energies, magnetic field strength, and bulk Lorentz factor of the emission region. The simulated light curves and spectral evolution of Mrk 421 during this period imply an almost linear correlation between X-ray flux at 1-10 keV energies and VHE gamma-ray flux above 200 GeV, as has been previously exhibited by this source. Through this study, a general trend that has emerged for the role of physical parameters is that, as the flare evolves from a low- to a high-flux state, higher bulk kinetic energy is injected into the system with a harder particle population and a lower magnetic field strength.Comment: 13 pages, 5 figures, accepted for publication in MNRA

An integrated perspective on measuring cytokines to inform CAR-T bioprocessing

Chimeric antigen receptor (CAR)-T cells are emerging as a generation-defining therapeutic however their manufacture remains a major barrier to meeting increased market demand. Monitoring critical quality attributes (CQAs) and critical process parameters (CPPs) during manufacture would vastly enrich acquired information related to the process and product, providing feedback to enable real-time decision making. Here we identify specific CAR-T cytokines as value-adding analytes and discuss their roles as plausible CPPs and CQAs. High sensitivity sensing technologies which can be easily integrated into manufacture workflows are essential to implement real-time monitoring of these cytokines. We therefore present biosensors as enabling technologies and evaluate recent advancements in cytokine detection in cell cultures, offering promising translatability to CAR-T biomanufacture. Finally, we outline emerging sensing technologies with future promise, and provide an overall outlook on existing gaps to implementation and the optimal sensing platform to enable cytokine monitoring in CAR-T biomanufacture.</p

Finite Density QCD in the Chiral Limit

We present the first results of an exact simulation of full QCD at finite density in the chiral limit. We have used a MFA (Microcanonical Fermionic Average) inspired approach for the reconstruction of the Grand Canonical Partition Function of the theory; using the fugacity expansion of the fermionic determinant we are able to move continuously in the ($\beta -\mu$) plane with $m=0$.Comment: 3 pages, LaTeX, 3 figures, uses espcrc2.sty, psfig. Talk presented by A. Galante at Lattice 97. Correction of some reference

Anomalous Radio-Wave Scattering from Interstellar Plasma Structures

This paper considers scattering screens that have arbitrary spatial variations of scattering strength transverse to the line of sight, including screens that are spatially well confined, such as disks and filaments. We calculate the scattered image of a point source and the observed pulse shape of a scattered impulse. The consequences of screen confinement include: (1) Source image shapes that are determined by the physical extent of the screen rather than by the shapes of much-smaller diffracting microirregularities. These include image elongations and orientations that are frequency dependent. (2) Variation with frequency of angular broadening that is much weaker than the trademark \nu^{-2} scaling law (for a cold, unmagnetized plasma), including frequency-independent cases; and (3) Similar departure of the pulse broadening time from the usually expected \nu^{-4} scaling law. We briefly discuss applications that include scattering of pulses from the Crab pulsar by filaments in the Crab Nebula; image asymmetries from Galactic scattering of the sources Cyg X-3, Sgr A*, and NGC 6334B; and scattering of background active galactic nuclei by intervening galaxies. We also address the consequences for inferences about the shape of the wavenumber spectrum of electron density irregularities, which depend on scaling laws for the image size and the pulse broadening. Future low-frequency (< 100 MHz) array observations will also be strongly affected by the Galactic structure of scattering material. Our formalism is derived in the context of radio scattering by plasma density fluctuations. It is also applicable to optical, UV and X-ray scattering by grains in the interstellar medium.Comment: 21 pages, LaTeX2e with AASTeX-4.0, 6 PostScript figures, accepted by ApJ, revised version has minor changes to respond to referee comments and suggestion

Reentrant phase behaviour for systems with competition between phase separation and self-assembly

In patchy particle systems where there is competition between the self-assembly of finite clusters and liquid-vapour phase separation, reentrant phase behaviour is observed, with the system passing from a monomeric vapour phase to a region of liquid-vapour phase coexistence and then to a vapour phase of clusters as the temperature is decreased at constant density. Here, we present a classical statistical mechanical approach to the determination of the complete phase diagram of such a system. We model the system as a van der Waals fluid, but one where the monomers can assemble into monodisperse clusters that have no attractive interactions with any of the other species. The resulting phase diagrams show a clear region of reentrance. However, for the most physically reasonable parameter values of the model, this behaviour is restricted to a certain range of density, with phase separation still persisting at high densities.Comment: 13 pages, 10 figure

Consideration of permanent tidal deformation in the orbit determination and data analysis for the Topex/Poseidon mission

The effects of the permanent tidal effects of the Sun and Moon with specific applications to satellite altimeter data reduction are reviewed in the context of a consistent definition of geoid undulations. Three situations are applicable not only for altimeter reduction and geoid definition, but also for the second degree zonal harmonic of the geopotential and the equatorial radius. A recommendation is made that sea surface heights and geoid undulations placed on the Topex/Poseidon geophysical data record should be referred to the mean Earth case (i.e., with the permanent effects of the Sun and Moon included). Numerical constants for a number of parameters, including a flattening and geoid geopotential, are included

High titers of transmissible spongiform encephalopathy infectivity associated with extremely low levels of PrP in vivo

Rona Barron - ORCID: 0000-0003-4512-9177 https://orcid.org/0000-0003-4512-9177Diagnosis of transmissible spongiform encephalopathy (TSE) disease in humans and ruminants relies on the detection in post-mortem brain tissue of the protease-resistant form of the host glycoprotein PrP. The presence of this abnormal isoform (PrPSc) in tissues is taken as indicative of the presence of TSE infectivity. Here we demonstrate conclusively that high titers of TSE infectivity can be present in brain tissue of animals that show clinical and vacuolar signs of TSE disease but contain low or undetectable levels of PrPSc. This work questions the correlation between PrPSc level and the titer of infectivity and shows that tissues containing little or no proteinase K-resistant PrP can be infectious and harbor high titers of TSE infectivity. Reliance on protease-resistant PrPSc as a sole measure of infectivity may therefore in some instances significantly underestimate biological properties of diagnostic samples, thereby undermining efforts to contain and eradicate TSEs.https://doi.org/10.1074/jbc.M704329200282pubpub4

Estimating Small Area Income Deprivation: An Iterative Proportional Fitting Approach

Small area estimation and in particular the estimation of small area income deprivation has potential value in the development of new or alternative components of multiple deprivation indices. These new approaches enable the development of income distribution threshold based as opposed to benefit count based measures of income deprivation and so enable the alignment of regional and national measures such as the Households Below Average Income with small area measures. This paper briefly reviews a number of approaches to small area estimation before describing in some detail an iterative proportional fitting based spatial microsimulation approach. This approach is then applied to the estimation of small area HBAI rates at the small area level in Wales in 2003-5. The paper discusses the results of this approach, contrasts them with contemporary ‘official’ income deprivation measures for the same areas and describes a range of ways to assess the robustness of the results

Lexical Derivation of the PINT Taxonomy of Goals: Prominence, Inclusiveness, Negativity Prevention, and Tradition

What do people want? Few questions are more fundamental to psychological science than this. Yet, existing taxonomies disagree on both the number and content of goals. We thus adopted a lexical approach and investigated the structure of goal-relevant words from the natural English lexicon. Through an intensive rating process, 1,060 goal-relevant English words were first located. In Studies 1-2, two relatively large and diverse samples (total n = 1,026) rated their commitment to approaching or avoiding these goals. Principal component analyses yielded 4 replicable components: Prominence, Inclusiveness, Negativity prevention, and Tradition (the PINT Taxonomy). Study 3-7 (total n = 1,396) supported the 4-factor structure of an abbreviated scale and found systematic differences in their relationships with past goal-content measures, the Big 5 traits, affect, and need satisfaction. This investigation thus provides a data-driven taxonomy of higher-order goal-content and opens up a wide variety of fascinating lines for future research