The effects of vibration during maximal graded cycling exercise: A pilot study

Whole Body Vibration training is studied and used in different areas, related to sport performance and rehabilitation. However, few studies have investigated the effects of Vibration (Vib) exposure on aerobic performance through the application of this concept to cycling exercise. A specifically designed vibrating cycloergometer, the powerBIKETM, was used to compare the effects of Vib cycling exercise and normal cycling on different physiological parameters during maximal graded exercise test. Twelve recreationally active male adults (25 ± 4.8 yrs; 181.33 ± 5.47 cm; 80.66 ± 11.91 kg) performed two maximal incremental cycling tests with and without Vib in a blockrandomized order. The protocol consisted of a 4 min warm up at 70 rev·min -1 followed by incremental steps of 3 min each. Cycling cadence was increased at each step by 10 rev·min -1 until participants reached their volitional exhaustion. Respiratory gases (VO 2, VCO 2), Heart Rate, Blood Lactate and RPE were collected during the test. Paired t-tests and Correlation Coefficients were used for statistical analysis. A significantly greater (P<0.05) response in the VO 2, HR, BLa and RPE was observed during the Vib trial compare to normal cycling. No significant differences were found in the maximal aerobic power (Vib 34.32 ± 9.70 ml·kg -1·min -1; no Vib 40.11 ± 9.49 ml·kg -1·min -1). Adding Vib to cycling exercise seems eliciting a quicker energetic demand during maximal exercise. However, mechanical limitations of the vibrating prototype could have affected the final outcomes. Future studies with more comparative setting are recommended to deeply appraise this concept. © Journal of Sports Science and Medicine (2012)

Southern Italian teenagers: The older they get, the unfit they become with girls worse than boys: A cohort epidemiological study: The adolescents surveillance system for the obesity prevention project (ASSO)

Italy comprises a high proportion of people who never exercised. Low physical activity levels in adolescents is a risk factor for several disorders. The aim of this cohort epidemiological study was to compare physical fitness profiles between boys and girls with regard to age and gender and to identify health and fitness-related markers that contribute to the make-up of Southern Italian teenagers. Eight hundred eleven teenagers were assessed for anthropometric measurements and completed the 5 ASSO-fitness tests battery. Data were analyzed with a 2-way analysis of variance (ANOVA) for repeated measures to compare the effect of both age and gender on the fitness components. The boys' anthropometric measurements were superior than the girls as expected [weight, height, body mass index (BMI), and waist circumference]; the overall BMI was found in the normality range. The overall teenagers' fitness markers were found to be quite poor with the boys outperforming the girls in all fitness tests. The weak cardiorespiratory performance of the female teenagers was remarkable. The under 16 years old (-16 yrs) girls outperformed the over 16 years old (+16yrs) girls. There were less significant differences when comparing (-16) and (+16) yrs old mixed-gender groups. There were no correlations between the (-16) and (+16) yrs when both genders were considered. The trend analysis showed the younger teenagers might be ''catching up'' the older ones in both contexts. Gender significantly influenced all variables. Although age did not influence cardiorespiratory fitness, the older the teenagers the worse their health and fitness markers become with the older girls worse than their younger peers. 1 2017 the Author(s).Funding/support: The Adolescents and Surveillance System for the Obesity prevention (ASSO)Project (code GR-2008-1140742, CUP I85J10000500001), funded by the Italian Ministry of Health.Scopu

Bioelectrical impedance vector analysis (BIVA) in sport and exercise: Systematic review and future perspectives

Background Bioelectrical impedance vector analysis (BIVA) is a general concept that includes all methodologies used in the analysis of the bioelectrical vector, whereas the "classic" BIVA is a patented methodology included among these methods of analysis. Once this was clarified, the systematic review of the literature provides a deeper insight into the scope and range of application of BIVA in sport and exercise. Objective The main goal of this work was to systematically review the sources on the applications of BIVA in sport and exercise and to examine its usefulness and suitability as a technique for the evaluation of body composition, hydration status, and other physiological and clinical relevant characteristics, ultimately to trace future perspectives in this growing area, including a proposal for a research agenda. Methods Systematic literature searches in PubMed, SPORTDiscus and Scopus databases up to July, 2017 were conducted on any empirical investigations using phase-sensitive bioimpedance instruments to perform BIVA within exercise and sport contexts. The search included healthy sedentary individuals, physically active subjects and athletes. Result Nineteen eligible papers were included and classified as sixteen original articles and three scientific conference communications. Three studies analysed short-term variations in the hydration status evoked by exercise/training through whole-body measurements, eleven assessed whole-body body composition changes induced by long-term exercise, four compared athletic groups or populations using the whole-body assessment, and two analysed bioelectrical patterns of athletic injuries or muscle damage through localised bioimpedance measurements. Conclusions BIVA is a relatively new technique that has potential in sport and exercise, especially for the assessment of soft-tissue injury. On the other hand, the current tolerance ellipses of “classic” BIVA are not a valid method to identify dehydration in individual athletes and a new approach is needed. “Specific” BIVA, a method which proposes a correction of bioelectrical values for body geometry, emerges as the key to overcome “classic” BIVA limitations regarding the body composition assessment. Further research establishing standardised testing procedures and investigating the relationship between physiology and the bioelectrical signal in sport and exercise is needed. © 2018 Castizo-Olier et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.Scopu

Vibration Cycling Did Not Affect Energy Demands Compared to Normal Cycling During Maximal Graded Test

The aim of this study was to compare the physiological responses between a vibration induced cycling step protocol (Vib) and normal cycling (without vibration, no-Vib). Eighteen moderate trained males (age 24.1 ± 4.3 years; weight 76.5 ± 10.5 kg; height 178.0 ± 6.4 cm) have participated in this study. They randomly performed two gradual maximal exercise tests on two separate days using a new bike that automatically induces vibration cycling and the Corival cycle ergometer. The choice of two different bikes was made because of the impossibility to recreate the same power output without altering the cycling cadence on the vibration Bike. Both protocols were matched for power output and cycling cadence incrementations. Oxygen uptake (VO2), carbon dioxide production (VCO2), ventilation (VE), heart rate (HR), blood lactate and rating of perceived exertion (RPE) during each stage were continuously recorded. No statistical differences were founded for all variables when comparing the Vib to no-Vib trials, except a higher ventilation during the vibration trial at submaximal levels. The results of this study do not confirm those of previous studies stated that Vib increased metabolic demands during cycling exercise. Added vibration stimulus to an incremental cycling protocol does not affect physiological parameters.We would like to thank all the participants who took part in this investigation. A particular thank to Mr. Emanuele Gariffo who has substantially helped in the data collection. Also, our thank goes to the Sport Science Department at Greenwich University, London, United Kingdom, that logistically supported the study together with K. C. Wong Magna Fund at Ningbo University for their continuing encouragement

A meta-analysis of the validity of FFQ targeted to adolescents

Objective: The present work is aimed at meta-analysing validity studies of FFQ for adolescents, to investigate their overall accuracy and variables that can affect it negatively. Design: A meta-analysis of sixteen original articles was performed within the ASSO Project (Adolescents and Surveillance System in the Obesity prevention). Setting: The articles assessed the validity of FFQ for adolescents, compared with food records or 24 h recalls, with regard to energy and nutrient intakes. Subjects: Pearson’s or Spearman’s correlation coefficients, means/standard deviations, kappa agreement, percentiles and mean differences/limits of agreement (Bland–Altman method) were extracted. Pooled estimates were calculated and heterogeneity tested for correlation coefficients and means/standard deviations. A subgroup analysis assessed variables influencing FFQ accuracy. Results: An overall fair/high correlation between FFQ and reference method was found; a good agreement, measured through the intake mean comparison for all nutrients except sugar, carotene and K, was observed. Kappa values showed fair/moderate agreement; an overall good ability to rank adolescents according to energy and nutrient intakes was evidenced by data of percentiles; absolute validity was not confirmed by mean differences/limits of agreement. Interviewer administration mode, consumption interval of the previous year/6 months and high number of food items are major contributors to heterogeneity and thus can reduce FFQ accuracy. Conclusions: The meta-analysis shows that FFQ are accurate tools for collecting data and could be used for ranking adolescents in terms of energy and nutrient intakes. It suggests how the design and the validation of a new FFQ should be addressed

Liposarcoma of the extremities: MR imaging features and their correlation with pathologic data

SummaryObjectiveTo describe the MRI features of liposarcomas of the extremities and correlate them with data from the histologic subtypes.Material and methodsRetrospective study of 20 cases of liposarcoma of the extremities identified on MRI, surgically removed and confirmed at pathology. On MRI examination, T1- and T2-weighted fat-suppressed and non-fat-suppressed images were acquired then gadolinium-enhanced fat-suppressed T1-weighted images were obtained in at least two orthogonal planes.ResultsSixteen female and four male patients aged 12 to 77 years old at presentation, in 16 cases, with a slowly enlarging painless mass (demonstrating no associated local or general inflammatory components), located in the lower extremity (16 cases) and predominantly located in the thigh (13 cases). Pathologic examination revealed three cases of well-differentiated liposarcoma, 12 cases of myxoid liposarcoma one of which with round cells, three cases of pleomorphic liposarcoma, one case of dedifferentiated liposarcoma and one case of mixed-type liposarcoma. MR images mostly showed well-circumscribed tumors (19 cases) . Well-differentiated liposarcomas typically demonstrated a very specific diagnostic appearance as a predominantly adipose mass containing nonlipomatous components seen as thick septa that may show nodularity. Other subtypes of liposarcoma demonstrated a small amount of adipose tissue thus producing a marbled textural pattern on T1-weighted images particularly in myxoid liposarcomas (9 cases), or even nonlipomatous elements in high-grade liposarcomas (in round cell liposarcoma and in two out of three pleomorphic liposarcomas). The myxoid subtype has also a relatively characteristic appearance as a low signal intensity noted on T1-weighted images and a marked high signal intensity on T2. The dedifferentiated liposarcoma has a very specific radiologic appearance as a nonlipomatous component within a predominantly adipose mass, simulating that of well-differentiated liposarcomas.ConclusionMRI of extremity liposarcomas is a highly reliable and sensitive method to characterize liposarcomas. Besides its value in the diagnosis of liposarcoma and locoregional extension control, it allows proper identification of the specific histologic subtypes of liposarcoma.Level of evidenceLevel IV. Rétrospective diagnostic study

Laparoscopic nephrectomy for giant staghorn calculus with non-functioning kidneys: Is associated unsuspected urothelial carcinoma responsible for conversion? Report of 2 cases

BACKGROUND-: Neglected renal stones remain a major cause of morbidity in developing countries. They not only result in functional impairment of affected kidney, but also act as an important predisposing factor for development of urothelial neoplasms. It is not uncommon to miss an associated urothelial tumor in a patient of nephrolithiasis preoperatively. CASE PRESENTATION-: In last 3 years, we came across two patients with giant staghorn calculus and poorly functioning kidneys who underwent laparoscopic nephrectomy. In view of significant perirenal adhesions & loss of normal tissue planes both these patients were electively converted to open surgery. The pathological examination of specimen revealed an unsuspected urothelial carcinoma in both these patients. The summary of our cases and review of literature is presented. CONCLUSION-: It is important to keep a differential diagnosis of associated urothelial malignancy in mind in patient presenting with long standing renal calculi. The exact role of a computerized tomography and cytology in preoperative workup for detection of possible associated malignancy in such condition is yet to be defined. Similarly if laparoscopic dissection appears difficult during nephrectomy for a renal calculus with non-functional kidney, keeping a possibility of associated urothelial malignancy in mind it is advisable to dissect in a plane outside gerotas fascia as for radical nephrectomy

In silico analysis of alpha1-antitrypsin variants: The effects of a novel mutation

Alpha1-antitrypsin (AAT) is a highly polymorphic protein with more than 120 variants that are classified as normal (normal protein secretion), deficient (reduced circulating AAT level caused by defective secretion) or null (no protein secretion). Alpha1-antitrypsin deficiency, one of the most common genetic disorders, predisposes adults to pulmonary emphysema and, to a lesser extent, chronic liver disease and cirrhosis. In this report, we provide additional sequence data for alpha1-antitrypsin based on the characterization of a novel variant detected in a 53-year-old heterozygous patient with chronic obstructive pulmonary disease. The mutation occurred on a PI*M2 base allele and was characterized by a T → C transition at nt 97 in exon II that led to the replacement of phenylalanine by leucine (F33L). Since the mutation was found in the heterozygous state with the expression of a normally secreted variant (PI*M1) it was not possible to assess the pattern of F33L secretion. However, computational analyses based on evolutionary, structural and functional information indicated a reduction of 23 Å 3 in the side chain volume and the creation of a cavity in the protein hydrophobic core that likely disturbed the tridimensional structure and folding of AAT. The accuracy of the in silico prediction was confirmed by testing known mutations

Alpha-1 antitrypsin gene polymorphism in Chronic Obstructive Pulmonary Disease (COPD)

Alpha-1-antitrypsin (AAT) plays an important role in the pathogenesis of emphysema, the pathological lesion underlying the majority of the manifestations of Chronic Obstructive Pulmonary Disease (COPD). In this study we tested the hypothesis that common AAT polymorphisms influence the risk of developing COPDs. We investigated PiM1 (Ala213Val), PiM2 (Arg101His), PiM3 (Glu376Asp), PiS (Glu264Val) and PiZ (Glu342Lys) SERPINA1 alleles in 100 COPD patients and 200 healthy controls. No significant differences were observed in allele frequencies between COPD patients and controls, neither did haplotype analysis show significant differences between the two groups. A cross-sectional study revealed no significant relationship between common SERPINA1 polymorphisms (PiM1, PiM2, PiM3) and the emphysematous type of COPD. In addition, FEV1 annual decline, determined during a two-year follow up period, revealed no difference among carriers of the tested polymorphisms