220 research outputs found
Search for Point Sources of Ultra-High Energy Cosmic Rays Above 40 EeV Using a Maximum Likelihood Ratio Test
We present the results of a search for cosmic ray point sources at energies
above 40 EeV in the combined data sets recorded by the AGASA and HiRes stereo
experiments. The analysis is based on a maximum likelihood ratio test using the
probability density function for each event rather than requiring an a priori
choice of a fixed angular bin size. No statistically significant clustering of
events consistent with a point source is found.Comment: 7 pages, 7 figures. Accepted for publication in The Astrophysical
Journa
An upper limit on the electron-neutrino flux from the HiRes detector
Air-fluorescence detectors such as the High Resolution Fly's Eye (HiRes)
detector are very sensitive to upward-going, Earth-skimming ultrahigh energy
electron-neutrino-induced showers. This is due to the relatively large
interaction cross sections of these high-energy neutrinos and to the
Landau-Pomeranchuk-Migdal (LPM) effect. The LPM effect causes a significant
decrease in the cross sections for bremsstrahlung and pair production, allowing
charged-current electron-neutrino-induced showers occurring deep in the Earth's
crust to be detectable as they exit the Earth into the atmosphere. A search for
upward-going neutrino-induced showers in the HiRes-II monocular dataset has
yielded a null result. From an LPM calculation of the energy spectrum of
charged particles as a function of primary energy and depth for
electron-induced showers in rock, we calculate the shape of the resulting
profile of these showers in air. We describe a full detector Monte Carlo
simulation to determine the detector response to upward-going
electron-neutrino-induced cascades and present an upper limit on the flux of
electron-neutrinos.Comment: 13 pages, 3 figures. submitted to Astrophysical Journa
Single-nucleus multi-omics of human stem cell-derived islets identifies deficiencies in lineage specification
Insulin-producing ÎČ cells created from human pluripotent stem cells have potential as a therapy for insulin-dependent diabetes, but human pluripotent stem cell-derived islets (SC-islets) still differ from their in vivo counterparts. To better understand the state of cell types within SC-islets and identify lineage specification deficiencies, we used single-nucleus multi-omic sequencing to analyse chromatin accessibility and transcriptional profiles of SC-islets and primary human islets. Here we provide an analysis that enabled the derivation of gene lists and activity for identifying each SC-islet cell type compared with primary islets. Within SC-islets, we found that the difference between ÎČ cells and awry enterochromaffin-like cells is a gradient of cell states rather than a stark difference in identity. Furthermore, transplantation of SC-islets in vivo improved cellular identities overtime, while long-term in vitro culture did not. Collectively, our results highlight the importance of chromatin and transcriptional landscapes during islet cell specification and maturation
Search for Correlations between HiRes Stereo Events and Active Galactic Nuclei
We have searched for correlations between the pointing directions of
ultrahigh energy cosmic rays observed by the High Resolution Fly's Eye
experiment and Active Galactic Nuclei (AGN) visible from its northern
hemisphere location. No correlations, other than random correlations, have been
found. We report our results using search parameters prescribed by the Pierre
Auger collaboration. Using these parameters, the Auger collaboration concludes
that a positive correlation exists for sources visible to their southern
hemisphere location. We also describe results using two methods for determining
the chance probability of correlations: one in which a hypothesis is formed
from scanning one half of the data and tested on the second half, and another
which involves a scan over the entire data set. The most significant
correlation found occurred with a chance probability of 24%.Comment: 13 pages, 1 table, 5 figure
Air fluorescence measurements in the spectral range 300-420 nm using a 28.5 GeV electron beam
Measurements are reported of the yield and spectrum of fluorescence, excited
by a 28.5 GeV electron beam, in air at a range of pressures of interest to
ultra-high energy cosmic ray detectors. The wavelength range was 300 - 420 nm.
System calibration has been performed using Rayleigh scattering of a nitrogen
laser beam. In atmospheric pressure dry air at 304 K the yield is 20.8 +/- 1.6
photons per MeV.Comment: 29 pages, 10 figures. Submitted to Astroparticle Physic
Why Lyme Disease is Common in the Northern US, but Rare in the South: The Roles of Host Choice, Host-seeking Behavior, and Tick Density
Lyme disease is common in the northeastern United States, but rare in the southeast, even though the tick vector is found in both regions. Infection prevalence of Lyme spirochetes in host-seeking ticks, an important component to the risk of Lyme disease, is also high in the northeast and northern midwest, but declines sharply in the south. As ticks must acquire Lyme spirochetes from infected vertebrate hosts, the role of wildlife species composition on Lyme disease risk has been a topic of lively academic discussion. We compared tickâvertebrate host interactions using standardized sampling methods among 8 sites scattered throughout the eastern US. Geographical trends in diversity of tick hosts are gradual and do not match the sharp decline in prevalence at southern sites, but tickâhost associations show a clear shift from mammals in the north to reptiles in the south. Tick infection prevalence declines north to south largely because of high tick infestation of efficient spirochete reservoir hosts (rodents and shrews) in the north but not in the south. Minimal infestation of small mammals in the south results from strong selective attachment to lizards such as skinks (which are inefficient reservoirs for Lyme spirochetes) in the southern states. Selective host choice, along with latitudinal differences in tick host-seeking behavior and variations in tick densities, explains the geographic pattern of Lyme disease in the eastern US
Improving Landsat predictions of rangeland fractional cover with multi-task learning and uncertainty
Microfluidic device facilitates in vitro modeling of human neonatal necrotizing enterocolitis-on-a-chip
Necrotizing enterocolitis (NEC) is a deadly gastrointestinal disease of premature infants that is associated with an exaggerated inflammatory response, dysbiosis of the gut microbiome, decreased epithelial cell proliferation, and gut barrier disruption. We describe an in vitro model of the human neonatal small intestinal epithelium (Neonatal-Intestine-on-a-Chip) that mimics key features of intestinal physiology. This model utilizes intestinal enteroids grown from surgically harvested intestinal tissue from premature infants and cocultured with human intestinal microvascular endothelial cells within a microfluidic device. We used our Neonatal-Intestine-on-a-Chip to recapitulate NEC pathophysiology by adding infant-derived microbiota. This model, named NEC-on-a-Chip, simulates the predominant features of NEC, including significant upregulation of proinflammatory cytokines, decreased intestinal epithelial cell markers, reduced epithelial proliferation, and disrupted epithelial barrier integrity. NEC-on-a-Chip provides an improved preclinical model of NEC that facilitates comprehensive analysis of the pathophysiology of NEC using precious clinical samples. This model is an advance toward a personalized medicine approach to test new therapeutics for this devastating disease
Observation of the Ankle and Evidence for a High-Energy Break in the Cosmic Ray Spectrum
We have measured the cosmic ray spectrum at energies above eV using
the two air fluorescence detectors of the High Resolution Fly's Eye experiment
operating in monocular mode. We describe the detector, PMT and atmospheric
calibrations, and the analysis techniques for the two detectors. We fit the
spectrum to models describing galactic and extragalactic sources. Our measured
spectrum gives an observation of a feature known as the ``ankle'' near eV, and strong evidence for a suppression near eV.Comment: 14 pages, 9 figures. To appear in Physics Letters B. Accepted versio
- âŠ