MObile Technology for Improved Family Planning: update to randomised controlled trial protocol.

BACKGROUND: This update outlines changes to the MObile Technology for Improved Family Planning study statistical analysis plan and plans for long-term follow-up. These changes result from obtaining additional funding and the decision to restrict the primary analysis to participants with available follow-up data. The changes were agreed prior to finalising the statistical analysis plan and sealing the dataset. METHODS/DESIGN: The primary analysis will now be restricted to subjects with data on the primary outcome at 4-month follow-up. The extreme-case scenario, where all those lost to follow-up are counted as non-adherent, will be used in a sensitivity analysis. In addition to the secondary outcomes outlined in the protocol, we will assess the effect of the intervention on long-acting contraception (implant, intra-uterine device and permanent methods).To assess the long-term effect of the intervention, we plan to conduct additional 12-month follow-up by telephone self-report for all the primary and secondary outcomes used at 4 months. All participants provided informed consent for this additional follow-up when recruited to the trial. Outcome measures and analysis at 12 months will be similar to those at the 4-month follow-up. The primary outcomes of the trial will be the use of an effective modern contraceptive method at 4 months and at 12 months post-abortion. Secondary outcomes will include long-acting contraception use, self-reported pregnancy, repeat abortion and contraception use over the 12-month post-abortion period. DISCUSSION: Restricting the primary analysis to those with follow-up data is the standard approach for trial analysis and will facilitate comparison with other trials of interventions designed to increase contraception uptake or use. Undertaking 12-month trial follow-up will allow us to evaluate the long-term effect of the intervention. TRIAL REGISTRATION: ClinicalTrials.gov NCT01823861

A Fast Conservative Spectral Solver For The Nonlinear Boltzmann Collision Operator

We present a conservative spectral method for the fully nonlinear Boltzmann collision operator based on the weighted convolution structure in Fourier space developed by Gamba and Tharkabhushnanam.. This method can simulate a broad class of collisions, including both elastic and inelastic collisions as well as angularly dependent cross sections in which grazing collisions play a major role. The extension presented in this paper consists of factorizing the convolution weight on quadrature points by exploiting the symmetric nature of the particle interaction law, which reduces the computational cost and memory requirements of the method to O(M(2)N(4)logN) from the O(N-6) complexity of the original spectral method, where N is the number of velocity grid points in each velocity dimension and M is the number of quadrature points in the factorization, which can be taken to be much smaller than N. We present preliminary numerical results.Mathematic

How does a protein search for the specific site on DNA: the role of disorder

Proteins can locate their specific targets on DNA up to two orders of magnitude faster than the Smoluchowski three-dimensional diffusion rate. This happens due to non-specific adsorption of proteins to DNA and subsequent one-dimensional sliding along DNA. We call such one-dimensional route towards the target "antenna". We studied the role of the dispersion of nonspecific binding energies within the antenna due to quasi random sequence of natural DNA. Random energy profile for sliding proteins slows the searching rate for the target. We show that this slowdown is different for the macroscopic and mesoscopic antennas.Comment: 4 pages, 4 figure

Statistical properties of the low-temperature conductance peak-heights for Corbino discs in the quantum Hall regime

A recent theory has provided a possible explanation for the ``non-universal scaling'' of the low-temperature conductance (and conductivity) peak-heights of two-dimensional electron systems in the integer and fractional quantum Hall regimes. This explanation is based on the hypothesis that samples which show this behavior contain density inhomogeneities. Theory then relates the non-universal conductance peak-heights to the ``number of alternating percolation clusters'' of a continuum percolation model defined on the spatially-varying local carrier density. We discuss the statistical properties of the number of alternating percolation clusters for Corbino disc samples characterized by random density fluctuations which have a correlation length small compared to the sample size. This allows a determination of the statistical properties of the low-temperature conductance peak-heights of such samples. We focus on a range of filling fraction at the center of the plateau transition for which the percolation model may be considered to be critical. We appeal to conformal invariance of critical percolation and argue that the properties of interest are directly related to the corresponding quantities calculated numerically for bond-percolation on a cylinder. Our results allow a lower bound to be placed on the non-universal conductance peak-heights, and we compare these results with recent experimental measurements.Comment: 7 pages, 4 postscript figures included. Revtex with epsf.tex and multicol.sty. The revised version contains some additional discussion of the theory and slightly improved numerical result

Opposite spin accumulations on the transverse edges by the confining potential

We show that the spin-orbit interaction induced by the boundary confining potential causes opposite spin accumulations on the transverse edges in a zonal two-dimensional electron gas in the presence of external longitudinal electric field. While the bias is reversed, the spin polarized direction is also reversed. The intensity of the spin accumulation is proportional to the bias voltage. In contrast to the bulk extrinsic and intrinsic spin Hall effects, the spin accumulation by the confining potential is almost unaffected by impurity and survives even in strong disorder. The result provides a new mechanism to explain the recent experimental data.Comment: 5 pages, 6 figure

On stochasticity in nearly-elastic systems

Nearly-elastic model systems with one or two degrees of freedom are considered: the system is undergoing a small loss of energy in each collision with the "wall". We show that instabilities in this purely deterministic system lead to stochasticity of its long-time behavior. Various ways to give a rigorous meaning to the last statement are considered. All of them, if applicable, lead to the same stochasticity which is described explicitly. So that the stochasticity of the long-time behavior is an intrinsic property of the deterministic systems.Comment: 35 pages, 12 figures, already online at Stochastics and Dynamic

Mode-locking of incommensurate phase by quantum zero point energy in the Frenkel-Kontorova model

In this paper, it is shown that a configuration modulated system described by the Frenkel-Kontorova model can be locked at an incommensurate phase when the quantum zero point energy is taken into account. It is also found that the specific heat for an incommensurate phase shows different parameter-dependence in sliding phase and pinning phase. These findings provide a possible way for experimentalists to verify the phase transition by breaking of analyticity.Comment: 6 pages in Europhys style, 3 eps figure

Localized Modes in Open One-Dimensional Dissipative Random Systems

We consider, both theoretically and experimentally, the excitation and detection of the localized quasi-modes (resonances) in an open dissipative 1D random system. We show that even though the amplitude of transmission drops dramatically so that it cannot be observed in the presence of small losses, resonances are still clearly exhibited in reflection. Surprisingly, small losses essentially improve conditions for the detection of resonances in reflection as compared with the lossless case. An algorithm is proposed and tested to retrieve sample parameters and resonances characteristics inside the random system exclusively from reflection measurements.Comment: 5 pages, 3 figures, to appear in Phys. Rev. Let

Fulde-Ferrell-Larkin-Ovchinnikov states in one-dimensional spin-polarized ultracold atomic Fermi gases

We present a systematic study of quantum phases in a one-dimensional spin-polarized Fermi gas. Three comparative theoretical methods are used to explore the phase diagram at zero temperature: the mean-field theory with either an order parameter in a single-plane-wave form or a self-consistently determined order parameter using the Bogoliubov-de Gennes equations, as well as the exact soluble Bethe ansatz method. We find that a spatially inhomogeneous Fulde-Ferrell-Larkin-Ovchinnikov phase, which lies between the fully paired BCS state and the fully polarized normal state, dominates most of the phase diagram of a uniform gas. The phase transition from the BCS state to the Fulde-Ferrell-Larkin-Ovchinnikov phase is of second order, and therefore there are no phase separation states in one-dimensional homogeneous polarized gases. This is in sharp contrast to the three-dimensional situation, where a phase separation regime is predicted to occupy a very large space in the phase diagram. We conjecture that the prediction of the dominance of the phase separation phases in three dimension could be an artifact of the non-self-consistent mean-field approximation, which is heavily used in the study of three-dimensional polarized Fermi gases. We consider also the effect of a harmonic trapping potential on the phase diagram, and find that in this case the trap generally leads to phase separation, in accord with the experimental observations for a trapped gas in three dimension. We finally investigate the local fermionic density of states of the Fulde-Ferrell-Larkin-Ovchinnikov ansatz. A two-energy-gap structure is shown up, which could be used as an experimental probe of the Fulde-Ferrell-Larkin-Ovchinnikov states.Comment: 22 papes, 19 figure