3 research outputs found
Roles of IP3R and RyR Ca2+ Channels in Endoplasmic Reticulum Stress and Ī²-Cell Death
OBJECTIVEāEndoplasmic reticulum (ER) stress has been implicated in the pathogenesis of diabetes, but the roles of specific ER Ca2+ release channels in the ER stressāassociated apoptosis pathway remain unknown. Here, we examined the effects of stimulating or inhibiting the ER-resident inositol trisphosphate receptors (IP3Rs) and the ryanodine receptors (RyRs) on the induction of Ī²-cell ER stress and apoptosis