Asymmetric adjustment in the City of London office market

Earlier estimates of the City of London office market are extended by considering a longer time series of data, covering two cycles, and by explicitly modeling of asymmetric space market responses to employment and supply shocks. A long run structural model linking real rental levels, office-based employment and the supply of office space is estimated and then rental adjustment processes are modeled using an error correction model framework. Rental adjustment is seen to be asymmetric, depending both on the direction of the supply and demand shocks and on the state of the space market at the time of the shock. Vacancy adjustment does not display asymmetries. There is also a supply adjustment equation. Two three-equation systems, one with symmetric rental adjustment and the other with asymmetric adjustment, are subjected to positive and negative shocks to employment. These illustrate differences in the two systems

Teff and log g dependence of velocity fields in M-stars

We present an investigation of velocity fields in early to late M-type hydrodynamic stellar atmosphere models. These velocities will be expressed in classical terms of micro- and macro-turbulent velocities for usage in 1D spectral synthesis. The M-star model parameters range between log g of 3.0 - 5.0 and Teff of 2500 K - 4000 K. We characterize the Teff- and log g-dependence of the hydrodynamical velocity fields in these models with a binning method, and for the determination of micro-turbulent velocities, the Curve of Growth method is used. The macro-turbulent velocities are obtained by convolutions with Gaussian profiles. Velocity fields in M-stars strongly depend on log g and Teff. Their velocity amplitudes increase with decreasing log g and increasing Teff. The 3D hydrodynamical and 1D macro-turbulent velocities range from ~100 m/s for cool high gravity models to ~ 800 m/s - 1000 m/s for hot models or models with low log g. The micro-turbulent velocities range in the order of ~100 m/s for cool models, to ~600 m/s for hot or low log g models. Our M-star structure models are calculated with the 3D radiative-hydrodynamics (RHD) code CO5BOLD. The spectral synthesis on these models is performed with the line synthesis code LINFOR3D.Comment: 8 pages, 6 Figures, Proceeding fot the "Recent directions in astrophysical quantitative spectroscopy and radiation hydrodynamics" conferenc

3D Radiative Transfer with PHOENIX

Using the methods of general relativity Lindquist derived the radiative transfer equation that is correct to all orders in v/c. Mihalas developed a method of solution for the important case of monotonic velocity fields with spherically symmetry. We have developed the generalized atmosphere code PHOENIX, which in 1-D has used the framework of Mihalas to solve the radiative transfer equation (RTE) in 1-D moving flows. We describe our recent work including 3-D radiation transfer in PHOENIX and particularly including moving flows exactly using a novel affine method. We briefly discuss quantitative spectroscopy in supernovae.Comment: 13 pages, 9 figures, to appear in Recent Directions in Astrophysical Quantitative Spectroscopy and Radiation Hydrodynamics, Ed. I. Hubeny, American Institute of Physics (2009

A Receptor's Tale: An Eon in the Life of a Trypanosome Receptor

African trypanosomes have complex life cycles comprising at least ten developmental forms, variously adapted to different niches in their tsetse fly vector and their mammalian hosts. Unlike many other protozoan pathogens, they are always extracellular and have evolved intricate surface coats that allow them to obtain nutrients while also protecting them from the immune defenses of either insects or mammals. The acquisition of macromolecular nutrients requires receptors that function within the context of these surface coats. The best understood of these is the haptoglobin-hemoglobin receptor (HpHbR) of $\textit{Trypanosoma brucei}$, which is used by the mammalian bloodstream form of the parasite, allowing heme acquisition. However, in some primates it also provides an uptake route for trypanolytic factor-1, a mediator of innate immunity against trypanosome infection. Recent studies have shown that during the evolution of African trypanosome species the receptor has diversified in function from a hemoglobin receptor predominantly expressed in the tsetse fly to a haptoglobin-hemoglobin receptor predominantly expressed in the mammalian bloodstream. Structural and functional studies of homologous receptors from different trypanosome species have allowed us to propose an evolutionary history for how one receptor has adapted to different roles in different trypanosome species. They also highlight the challenges that a receptor faces in operating on the complex trypanosome surface and show how these challenges can be met.This has been funded by the Medical Research Council (Grant reference MR/L008246/1) and the Wellcome Trust (reference: 101020/Z/13/Z)

Genetic variation of Amaranthus retroflexus L. and Chenopodium album L. (Amaranthaceae) suggests multiple independent introductions into Iran

Amaranthus retroflexus L. and Chenopodium album L. (Amaranthaceae) are weedy plants that cause severe ecological and economic damage. In this study, we collected DNA from three different countries and assessed genetic diversity using inter-simple sequence repeat (ISSR) markers. Our analysis shows both weed species have low genetic diversity within a population and high genetic diversity among populations, as well as a low value of gene flow among the populations. UPGMA clustering and principal coordinate analysis indicate four distinct groups for A. retroflexus L. and C. album L. exist. We detected significant isolation-by-distance for A. retroflexus L. and no significant correlation for C. album L. These conclusions are based data from 13 ISSR primers where the average percentage of polymorphism produced was 98.46 % for A. retroflexus L. and 74.81% for C. album L.. These data suggest that each population was independently introduced to the location from which it was sampled and these noxious weeds come armed with considerable genetic variability giving them the opportunity to manifest myriad traits that could be used to avoid management practices. Our results, albeit not definitive about this issue, do not support the native status of C. album L. in Iran

Perspectives of Nuclear Physics in Europe: NuPECC Long Range Plan 2010

The goal of this European Science Foundation Forward Look into the future of Nuclear Physics is to bring together the entire Nuclear Physics community in Europe to formulate a coherent plan of the best way to develop the field in the coming decade and beyond.<p></p> The primary aim of Nuclear Physics is to understand the origin, evolution, structure and phases of strongly interacting matter, which constitutes nearly 100% of the visible matter in the universe. This is an immensely important and challenging task that requires the concerted effort of scientists working in both theory and experiment, funding agencies, politicians and the public.<p></p> Nuclear Physics projects are often “big science”, which implies large investments and long lead times. They need careful forward planning and strong support from policy makers. This Forward Look provides an excellent tool to achieve this. It represents the outcome of detailed scrutiny by Europe’s leading experts and will help focus the views of the scientific community on the most promising directions in the field and create the basis for funding agencies to provide adequate support.<p></p> The current NuPECC Long Range Plan 2010 “Perspectives of Nuclear Physics in Europe” resulted from consultation with close to 6 000 scientists and engineers over a period of approximately one year. Its detailed recommendations are presented on the following pages. For the interested public, a short summary brochure has been produced to accompany the Forward Look.<p></p&gt

Assessment of the variability of airborne contamination levels in an intensive care unit over a 24 hour period

Introduction: The objective of this study was to evaluate the variability in the dynamics and levels of airborne contamination within a hospital ICU in order to establish an improved understanding of the extent to which airborne bioburden contributes to cross-infection of patients. Microorganisms from the respiratory tract or skin can become airborne by coughing, sneezing and periods of increased activity such as bed changes and staff rounds. Current knowledge of the clinical microflora is limited however it is estimated that 10-33% of nosocomial infections are transmitted via air. Methods: Environmental air monitoring was conducted in Glasgow Royal Infirmary ICU, in the open ward and in patient isolation rooms. A sieve impactor air sampler was used to collect 500 L air samples every 15 minutes over 10 hour (08:00-18:00 h) and 24 hour (08:00-08:00 h) periods. Samples were collected, room activity logged and the bacterial contamination levels were recorded as CFU/m3 of air. Results: A high degree of variability in levels of airborne contamination was observed over the course of a 10 hour day and a 24 period in a hospital ICU. Counts ranged from 12-510 CFU/m3 over 24 hours in an isolation room occupied for 10 days by a patient with C. difficile infection. Contamination levels were found to be lowest during the night and in unoccupied rooms, with an average value of 20 CFU/m3. Peaks in airborne contamination showed a direct relation to an increase in room activity. Conclusions: This study demonstrates the degree of airborne contamination that can occur in an ICU over a 24 hour period. Numerous factors were found to contribute to microbial air contamination and consideration should be given to potential improved infection control strategies and decontamination technologies which could be deployed within the clinical environment to reduce the airborne contamination levels, with the ultimate aim of reducing healthcare-associated infections from environmental sources

Electromechanical forces acting on bio-membranes in external electric fields

Membranes of microorganisms stressed with electric field can be deformed and ruptured due to unbalanced electro-mechanical forces. The paper provides an analytical analysis of the forces acting on bio-membranes in liquid and gaseous environment. This model can help in optimisation and further development of novel field and plasma based decontamination methods

Evaluation of the airborne contamination levels in an intensive care unit over a 24 hour period

Airborne transmission of infectious microorganisms poses a critical threat to human health, particularly in the clinical setting where it is estimated that 10-33% of nosocomial infections are spread via the air. Within the clinical environment, microorganisms originating from the human respiratory tract or skin can become airborne by coughing and sneezing, and periods of increased activity such as bed and dressing changes, movement, staff rounds and visiting hours. Current knowledge of the clinical airborne microflora is limited and there is uncertainty surrounding the contribution of airborne microorganisms to the transmission of nosocomial infection. This study aims to establish an improved understanding of the variability in the dynamics and levels of airborne microbial contamination within an operational intensive care unit (ICU). Methods Environmental monitoring of airborne contamination levels was conducted in Glasgow Royal Infirmary ICU, in the open ward and in both occupied and unoccupied patient isolation rooms. Monitoring was performed using a sieve impactor air sampler, with 500 L air samples collected every 15 minutes over 10 hour (08:00-18:00 h) and 24 hour (08:00-08:00 h) periods. Samples were collected on tryptone soya agar (TSA) plates, and the bacterial contamination levels were recorded as CFU/m3 of air. An activity log was also collated over the 10 hour and 24 hour sampling periods in order to record any activity occurring in the ward/room that might contribute to spikes in airborne contamination levels. Results Results highlight the degree of variability in levels of airborne contamination over the course of both a working day and a 24 hour period in a hospital ICU. A high degree of variability was observed across the 24 hour period, with counts ranging from 12-510 CFU/m3 in one study in an occupied patient room. Peaks in airborne contamination showed a direct relation to an increase in room activity. Monitoring found contamination levels to be lower overall during the night, and in unoccupied isolation rooms, with an average value of 20 CFU/m3. The highest counts were observed in an isolation room occupied for 10 days by a patient with C. difficile infection which generated an average microbial load of 104 CFU/m3 and a peak value of 510 CFU/m3. Discussion This study has demonstrated the degree of airborne contamination that can occur in the ICU environment over a 24 hour period. Numerous factors were found to contribute to the microbial air contamination levels, including patient status, length of room occupation, time of day and room activity, and further work is required to establish the extent to which this airborne bioburden contributes to cross-infection of patients