INTEGRAL high energy behaviour of 4U 1812-12

The low mass X-ray binary system 4U 1812-12 was monitored with the INTEGRAL observatory in the period 2003-2004 and with BeppoSAX on April 20, 2000. We report here on the spectral and temporal analysis of both persistent and burst emission. The full data set confirms the persistent nature of this burster, and reveals the presence of emission up to 200 keV. The persistent spectrum is well described by a comptonization (CompTT) model plus a soft blackbody component. The source was observed in a hard spectral state with a 1-200 keV luminosity of 2*10^(36) ergs/s and L/LEdd~1% and no meaningful flux variation has been revealed, as also confirmed by a 2004 RXTE observation. We have also detected 4 bursts showing double peaked profiles and blackbody spectra with temperatures ranging from 1.9 to 3.1 keV.Comment: 6 pages, 4 figures. Accepted for publication by A&

The X-ray spectrum of the bursting atoll source 4U~1728-34 observed with INTEGRAL

We present for the first time a study of the 3-200 keV broad band spectra of the bursting atoll source 4U 1728-34 (GX 354-0) along its hardness intensity diagram. The analysis was done using the INTEGRAL public and Galactic Center deep exposure data ranging from February 2003 to October 2004. The spectra are well described by a thermal Comptonization model with an electron temperature from 35 keV to 3 keV and Thomson optical depth, tau_T, from 0.5 to 5 in a slab geometry. The source undergoes a transition from an intermediate/hard to a soft state where the source luminosity increases from 2 to 12% of Eddington. We have also detected 36 type I X-ray bursts two of which show photospheric radius expansion. The energetic bursts with photospheric radius expansion occurred at an inferred low mass accretion rate per unit area of \dot m ~ 1.7x10E3 g/cm2/s, while the others at a higher one between 2.4x10E3 - 9.4x10E3 g/cm2/s. For 4U1728-34 the bursts' total fluence, and the bursts' peak flux are anti-correlated with the mass accretion rate. The type I X-ray bursts involve pure helium burning either during the hard state, or during the soft state of the source.Comment: 11 pages, 7 figures, and 2 tables. Accepted for publication in A&

MicroRNA networks surrounding APP and amyloid-β metabolism - implications for Alzheimer's disease

MicroRNAs (miRNAs) are small non-coding RNA regulators of protein synthesis that function as "fine-tuning" tools of gene expression in development and tissue homeostasis. Their profiles are significantly altered in neurodegenerative diseases such as Alzheimer's disease (AD) that is characterized by both amyloid-β (Aβ) and tau deposition in brain. A key challenge remains in determining how changes in miRNA profiles translate into biological function in a physiological and pathological context. The key lies in identifying specific target genes for deregulated miRNAs and understanding which pathogenic factors trigger their deregulation. Here we review the literature about the intricate network of miRNAs surrounding the regulation of the amyloid precursor protein (APP) from which Aβ is derived by proteolytic cleavage. Normal brain function is highly sensitive to any changes in APP metabolism and miRNAs function at several steps to ensure that the correct APP end product is produced and in the right form and abundance. Disruptions in this miRNA regulatory network may therefore alter Aβ production, which in turn can affect miRNA expression

Discovery of a Transition to Global Spin-up in EXO 2030+375

EXO 2030+375, a 42-second transient X-ray pulsar with a Be star companion, has been observed to undergo an outburst at nearly every periastron passage for the last 13.5 years. From 1994 through 2002, the global trend in the pulsar spin frequency was spin-down. Using RXTE data from 2003 September, we have observed a transition to global spin-up in EXO 2030+375. Although the spin frequency observations are sparse, the relative spin-up between 2002 June and 2003 September observations, along with an overall brightening of the outbursts since mid 2002 observed with the RXTE ASM, accompanied by an increase in density of the Be disk, indicated by infrared magnitudes, suggest that the pattern observed with BATSE of a roughly constant spin frequency, followed by spin-up, followed by spin-down is repeating. If so this pattern has approximately an 11 year period, similar to the 15 +/- 3 year period derived by Wilson et al. (2002) for the precession period of a one-armed oscillation in the Be disk. If this pattern is indeed repeating, we predict a transition from spin-up to spin-down in 2005.Comment: Accepted for publication in ApJ Letters, 4 pages, 5 figures, using emulateapj.cl

The Unique Frequency Spectrum of the Blazhko RRc Star LS Her

The Blazhko effect in RR Lyrae stars is still poorly understood theoretically. Stars with multiple Blazhko periods or in which the Blazhko effect itself varies are particularly challenging. This study investigates the Blazhko effect in the RRc star LS Her. Detailed VRI CCD photometry has been performed on 63 nights during six months. LS Her is confirmed to have a Blazhko period of 12.75+/-0.02 days. However, where normally the side frequencies of the Blazhko triplet are expected, an equidistant group of three frequencies is found on both sides of the main pulsation frequency. As a consequence the period and amplitude of the Blazhko effect itself vary in a cycle of 109+/-4 days. LS Her is a unique object turning out to be very important in the verification of the theories for the Blazhko effect.Comment: Accepted for publication in MNRA