An automated system for lung nodule detection in low-dose computed tomography

A computer-aided detection (CAD) system for the identification of pulmonary nodules in low-dose multi-detector helical Computed Tomography (CT) images was developed in the framework of the MAGIC-5 Italian project. One of the main goals of this project is to build a distributed database of lung CT scans in order to enable automated image analysis through a data and cpu GRID infrastructure. The basic modules of our lung-CAD system, a dot-enhancement filter for nodule candidate selection and a neural classifier for false-positive finding reduction, are described. The system was designed and tested for both internal and sub-pleural nodules. The results obtained on the collected database of low-dose thin-slice CT scans are shown in terms of free response receiver operating characteristic (FROC) curves and discussed.Comment: 9 pages, 9 figures; Proceedings of the SPIE Medical Imaging Conference, 17-22 February 2007, San Diego, California, USA, Vol. 6514, 65143

The interaction-strength interpolation method for main-group chemistry: benchmarking, limitations, and perspectives

We have tested the original interaction-strength-interpolation (ISI) exchange-correlation functional for main group chemistry. The ISI functional is based on an interpolation between the weak and strong coupling limits and includes exact-exchange as well as the G\"orling-Levy second-order energy. We have analyzed in detail the basis-set dependence of the ISI functional, its dependence on the ground-state orbitals, and the influence of the size-consistency problem. We show and explain some of the expected limitations of the ISI functional (i.e. for atomization energies), but also unexpected results, such as the good performance for the interaction energy of dispersion-bonded complexes when the ISI correlation is used as a correction to Hartree-Fock.Comment: 20 pages, 20 figure

Closing the Wedge: Search Strategies for Extended Higgs Sectors with Heavy Flavor Final States

We consider search strategies for an extended Higgs sector at the high-luminosity LHC14 utilizing multi-top final states. In the framework of a Two Higgs Doublet Model, the purely top final states ($t\bar t, \, 4t$) are important channels for heavy Higgs bosons with masses in the wedge above $2\,m_t$ and at low values of $\tan\beta$, while a $2 b 2t$ final state is most relevant at moderate values of $\tan \beta$. We find, in the $t\bar t H$ channel, with $H \rightarrow t \bar t$, that both single and 3 lepton final states can provide statistically significant constraints at low values of $\tan \beta$ for $m_A$ as high as $\sim 750$ GeV. When systematics on the $t \bar t$ background are taken into account, however, the 3 lepton final state is more powerful, though the precise constraint depends fairly sensitively on lepton fake rates. We also find that neither $2b2t$ nor $t \bar t$ final states provide constraints on additional heavy Higgs bosons with couplings to tops smaller than the top Yukawa due to expected systematic uncertainties in the $t \bar t$ background.Comment: Added a Fig. and updated references. Matches journal version. 31 pages, 11 figure

Development of a new screening tool for cyber pornography. Psychometric properties of the Cyber Pornography Addiction Test (CYPAT)

Objective: Internet pornography addiction typically involves viewing, downloading and trading online pornography or engagement in adult fantasy role-play. There are some well-validated inventories measuring perceived addiction to internet pornography but these instruments are often too long for a functionally use and fast scoring. The aim of this study was to evaluate the psychometric properties of the cyber pornography addiction test (CYPAT), a new, brief, screening measure for assessing cyber pornography.Method: Participants of this study completed the CYPAT, the CPUI, the TAS-20 and the FACES-IV. Descriptive statistics were calculated and Exploratory Factor Analysis (EFA) and Confirmatory Factor Analysis (CFA) were applied.Results: Cronbach's alpha coefficient suggested excellent reliability of the measure. Results of this study revealed also good construct, convergent and divergent validity.Conclusions: CYPAT is a brief self-report screening scale composed of 11 items scored on a five-point Likert scale with good psychometrics properties. The implications of these findings for future theoretical and empirical research in this field are discusse

Computer-aided detection of pulmonary nodules in low-dose CT

A computer-aided detection (CAD) system for the identification of pulmonary nodules in low-dose multi-detector helical CT images with 1.25 mm slice thickness is being developed in the framework of the INFN-supported MAGIC-5 Italian project. The basic modules of our lung-CAD system, a dot enhancement filter for nodule candidate selection and a voxel-based neural classifier for false-positive finding reduction, are described. Preliminary results obtained on the so-far collected database of lung CT scans are discussed.Comment: 3 pages, 4 figures; Proceedings of the CompIMAGE - International Symposium on Computational Modelling of Objects Represented in Images: Fundamentals, Methods and Applications, 20-21 Oct. 2006, Coimbra, Portuga

Vacuum Stability and Higgs Diphoton Decays in the MSSM

Current Higgs data at the Large Hadron Collider is compatible with a SM signal at the 2$\sigma$ level, but the central value of the signal strength in the diphoton channel is enhanced with respect to the SM expectation. If the enhancement resides in the diphoton partial decay width, the data could be accommodated in the Minimally Supersymmetric Standard Model (MSSM) with highly mixed light staus. We revisit the issue of vacuum instability induced by large mixing in the stau sector, including effects of a radiatively-corrected tau Yukawa coupling. Further, we emphasize the importance of taking into account the $\tan\beta$ dependence in the stability bound. While the metastability of the Universe constrains the possible enhancement in the Higgs to diphoton decay width in the light stau scenario, an increase of the order of 50% can be achieved in the region of large $\tan\beta$. Larger enhancements may be obtained, but would require values of $\tan\beta$ associated with non-perturbative values of the tau Yukawa coupling at scales below the GUT scale, thereby implying the presence of new physics beyond the MSSM.Comment: 25 pages, 7 figure

Deployment and surface accuracy of regularly creased membranes

Creases are highly localized regions ubiquitous across different length scales in low-dimensional natural and engineering systems. Their presence strongly influences the mechanical response and surface accuracy of creased membrane materials and structures. In this paper, we study the deployment of folded sheets composed of an arbitrary number of non-interacting and parallel creases. We develop a mathematical formulation that describes the nonlinear mechanics of systematically creased membranes composed of a single or multiple folds, and predicts their surface accuracy during unfolding. The proposed solution shows the contribution of membrane bending and crease energies during deployment, and reveals the presence of two dimensionless parameters that govern the unfolding behaviour. Sensitivity analyses are also performed to assess the influence of the crease geometry and constitutive behaviour. The analytical predictions are validated through finite element analyses and deployment tests performed on thin films with one, two and three fold lines, where imaging techniques are employed to quantify deformation. The excellent agreement between theoretical and experimental results testifies that the developed formulation represents a precise tool to assess the tensioning of creased membranes, with applications ranging from origami metamaterials to lightweight space structures where precise shape control is paramount

Prolonged low flow reduces reactive hyperemia and augments low flow mediated constriction in the brachial artery independent of the menstrual cycle

© 2013 Rakobowchuk et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.Non-invasive forearm ischemia-reperfusion injury and low flow induced vascular dysfunction models provide methods to evaluate vascular function. The role of oestrogen, an endogenous anti-oxidant on recovery from ischemia-reperfusion injury has not been evaluated nor has the impact of prolonged low flow on vascular function been established. Eight healthy women (33610 yr) attended the lab during the follicular, ovulatory and mid-luteal phases of their menstrual cycles. After 30 minutes of rest, brachial artery vascular function was assessed by ultrasound measurements of diameter changes during 5 minutes of forearm ischemia and 3 minutes after. Subsequently, a 20-minute forearm ischemia period was completed. Further, vascular function assessments were completed 15, 30 and 45 minutes into recovery. Flow-mediated dilation, lowflow-mediated constriction, and reactive hyperaemia proximal to the area of ischemia were determined. Flow-mediated dilation was reduced at 15 minutes of recovery but recovered at 30 and 45 minutes (PRE: 7.161.0%, POST15:4.560.6%, POST30:5. 560.7% POST45:5.960.4%, p,0.01). Conversely, low-flow mediated constriction increased (PRE: 21.360.4%, POST15: 23.360.6%, POST30: 22.560.5% POST45: 21.560.12%, p,0.01). Reactive hyperaemia was reduced throughout recovery (p,0.05). Data were unaffected by menstrual phase. Prolonged low flow altered vascular function and may relate as much to increased vasoconstriction as with decreased vasodilation. Reductions in anterograde shear and greater retrograde shear likely modulate the brachial artery response, but the reduced total shear also plays an important role. The data suggest substantial alterations in vascular function proximal to areas of ischemia with potential clinical implications following reperfusion.British Heart Foundation (PG/08/060/25340),a Physiological Society summer studentship to SG, and a Wellcome Trust Vacation Studentship to EP