STABILITY INDICATING RP-HPLC METHOD FOR ESTIMATION OF RABEPRAZOLE SODIUM AND MOSAPRIDE CITRATE IN BULK AND FORMULATION

Objective: Development and validation of reversed phase liquid chromatographic method for the quantitative determination of Rabeprazole sodium and Mosapride citrate in bulk and combined dosage form. Methods: A thermo Inert sil, C18 (250 x 4.6 mm i. d., 5 µ) column with mobile phase containing methanol: buffer (ammonium acetate pH 6.5): acetonitrile in the ratio of (50:20:30 %) was used. The flow rate was 1.0 ml/min, column temperature was 25 °C and effluents were monitored at 245 nm. Results: The retention times of Rabeprazole sodium and Mosapride citrate were 2.951 min and 4.195 min, respectively. Correlation co-efficient for Rabeprazole sodium and Mosapride citrate was found to be 0.9999 and 0.9999, respectively. The proposed method was validated with respect to linearity, accuracy, precision, specificity, and robustness. Recovery of Rabeprazole sodium and Mosapride citrate in formulations was found to be in the range of 97-103 % and 98-102 %, respectively confirms the non-interferences of the excipients in the formulation. Conclusion: The proposed HPLC method was found to be simple, precise, accurate and sensitive for the simultaneous estimation of Rabeprazole sodium and Mosapride citrate in pharmaceutical dosage forms. Due to its simplicity, rapidness and high precision, the method was successfully applied to the estimation of Rabeprazole sodium and Mosapride citrate in combined dosage form

Prolonged jaundice in an apparently healthy baby: A review

Jaundice persisting beyond 14 days of life is a commonly encountered problem in the neonatal follow-up clinic. Although by far the most common underlying etiology is breast milk jaundice, clinician should not miss out an important surgical condition the extrahepatic biliary atresia (an incidence of about 1 in 10000 live births) whose outcome without a surgical intervention before 8 weeks is dismal. Eminently treatable entities such as hypothyroidism and urinary tract infection also can present as prolonged jaundice. This article will synthesize the available literature on this topic and present an algorithm for evaluation of neonates presenting with prolonged jaundice useful to pediatricians in outpatient practice

A correlation of clinical, hormonal and ultrasonography features of polycystic ovarian syndrome among adolescent and reproductive age group women attending OPD in Navodaya medical college

Background: Polycystic ovarian syndrome is the most common complex endocrine disorder in women of reproductive age. It is characterized by an array of clinical, endocrinal and metabolic manifestation. Aim of this study was to examine the correlation between clinical, hormonal and ultrasonography features in women diagnosed as polycystic ovarian syndrome. Methods: A cross sectional study of 100 reproductive age group women who had irregular cycles and polycystic ovarian morphology on ultrasound. Data about the menstrual history and anthropometric measurements were collected. Clinical observations were like hirsuitism and acanthosis nigricans was noted. Results: In all 100 PCOS women were studied and analysed. The mean age was 24.27(±5.64), mean BMI was 26(±4.8). Among the PCOS women 82% had oligo menorrhoea, 38% had hirsuitism and LH:FSH ratio deranged in 37% cases. The association between women having oligomenorrhoea and obesity with PCO morphology on scan was statistically significant. Conclusions: Young women who are diagnosed as dysregulated PCO are at a high risk to develop PCOD and long term sequel such as diabetes, hypertension and infertility. Lifestyle modification is advisable for managing symptoms and preventing long term complications and have a quality life

DEMODULATION AND ANALYZING THE EFFECT OF DISTORTED FINGERPRINTS

Distortion rectification is known as the issue concerning regression where the distorted fingerprint forms the input and output could be the distortion field. Inside our work, novel algorithms were forecasted to cope with impracticality of fingerprint distortion. Identification of distortion is sighted since the problem of two class classification, that registered ridge orientation map furthermore to period map of fingerprint are utilized as feature vector. Support vector machine classifier is trained to cope with job of classification. The recommended system does not need any changes for the existing fingerprint sensors together with procedures of fingerprint acquisition. This rentals are significant for appropriate incorporation for your fliers and card printing of fingerprint recognition. Inside the forecasted system when specified a port fingerprint, recognition of distortion is transported out initially when it'll be distorted, later distortion rectification is transported to change input fingerprint with an ordinary one

Anomalous origin of the left vertebral artery from the arch of the aorta: review of the literature and a case report

The present report describes an anomalous case of the left vertebral artery arising from the aortic arch between the left common carotid artery and the left subclavian artery in a male cadaver during dissection in an anatomical laboratory. Aortic origin of the vertebral artery is a rare anatomic variant. Detailed knowledge of anomalous origin is important for patients who undergo four-vessel angiography. Normally, the vertebral artery arises from the first part of the subclavian artery on both sides. We also review the anomalous origin of the vertebral artery in the literature and discuss its clinical significance. (Folia Morphol 2010; 69, 4: 258-260

ANFIS based Wind Speed Sensor-less MPPT Controller for Variable Speed Wind Energy Conversion Systems

Keywords: Variable speed wind turbine, Doubly fed induction generator, Maximum power point tracking, Adaptive neurofuzzy inference system. Background: Although, wind energy is abundant, it varies frequently throughout the day depending on the environmental conditions. Such frequent wind speed variation, makes the necessity of maximum power point tracking device in the Wind Energy Conversion System (WECS). The amount of power output from a WECS depends upon the accuracy with which the peak power points are tracked by the maximum power point tracking controller of the WECS control system irrespective of the variable speed generator used. Objective: To reduce the complexity in tracking the optimal power from a variable speed wind energy conversion system. A Adaptive Neuro-Fuzzy Inference System (ANFIS) based Maximum Power Point Tracking (MPPT) technique is proposed. Results: Compared to the existing technique, the proposed method reduces the complexity in leaning the peak power. Furthermore, the proposed method forecasts the optimal rotor speed of the wind turbine using the measured wind speed. Therefore, by regulating the optimal rotor speed, maximum power is extracted. Conclusion: We have proposed a simple and accurate technique to extract maximum power from a grid connected variable speed operated doubly fed induction generator based WECS. The optimal rotor speed of the wind turbine is estimated by the proposed MPPT technique. Therefore, maximum power is extracted from WECS for variable wind condition by dynamically adjusting the speed control loop of the rotor side converter

Influence of different types of soils on the growth and yield of Quinoa (Chenopodium quinoa Wild.)

Quinoa is a resilient high-yielding pseudo cereal, gaining attention because of its high nutritional value, strong growth potential, and tremendous source of essential amino acids, micronutrients, vitamins, phenolic compounds, and minerals. The main aim of this investigation was to find the best suitable soil type for maximizing the growth and yield of Quinoa. The pot study was undertaken at the Department of Agronomy, Tamil Nadu Agricultural University, Coimbatore, during the Kharif 2022 season. Eight soil samples (clay loam soils of wetlands of TNAU, sandy loam soils of eastern block of TNAU, sandy loam soils of Mettupalayam, sandy clay loam soils of 36 B eastern block of TNAU, sandy clay loam soils of 37 B eastern block of TNAU, clay loam soils of Ooty, sandy clay loam soils of Govindanaickenpalayam and sandy clay loam soils of Annur) were collected round Coimbatore in Tamil Nadu and tested in a complete randomized design with three replications. The pot study results revealed that growth parameters viz. Plant height (81.5 cm), number of leaves plant-1 (164.8), leaf area (317.7 cm2), number of branches plant-1 (38.0) and dry matter production (22.78 g) were significantly higher in the clay loam soils of Ooty than all other soil types. Similarly, yield attributes such as the number of panicles plant-1 (21.7), panicle length (13.08 cm), number of grains panicle-1 (3050) and grain yield plant-1 (9.60 g) of Quinoa were also higher in the same clay loam soils followed by that in sandy clay loam soils of Govindanaickenpalayam. Red soils of Mettupalayam had shown the lowest growth, yield and yield attributes of Quinoa. Based on the above results, it was concluded that the clay loam soil of Ooty was the best suited for cultivating Quinoa crops

Solvent Effect on the Fluorescence Properties of Two Biologically Active Thiophene Carboxamido Molecules

The absorption and fluorescence spectra of two thiophene carboxamido molecules namely 2–( - trimethoxy phenyl) imino–3–N–ethylcarboxamido–4, 5, tetramethylene thiophene (X) and 2-( -N, N-dimethylaminophenyl) imino-3-(N- methylphenyl carboxamido)-4, 5, tetramethylene thiophene (Y) have been recorded at room temperature. The ground (mg) and excited (me) state dipole moments are estimated from Lippert, Bakhshiev, Kawski-Chamma-Viallet equations by using the variation of Stokes shift with microscopic solvent dielectric constant (e) and refractive index (n). The excited dipole moments were also estimated by using the variation of Stokes shift with microscopic empirical solvent polarity parameter and the values are compared. It was estimated that dipole moments of the excited state were higher than those of the ground state of both the molecules. Further, the change in dipole moment (Dm) were calculated both from solvatochromic shift method and on the basis of microscopic empirical solvent polarity parameter