Single custodial fathers : effects on families and implications for school counselors

This paper uses current published literature to determine characteristics of single father headed households in comparison to the characteristics of single mother headed households, as well as the effects of being raised by a single custodial father. The general characteristics of single father headed households that are examined include: family resources, role strain, parenting style, and support from others. Behavior, academic performance, and relationships and social development of children of single custodial fathers are briefly examined to explore the effects of being raised by a single custodial father. Implications for school counselors working with single custodial fathers and their children are also included

Prevention of rejection of murine islet allografts by pretreatment with anti-dendritic cell antibody

Faustman, D., Steinman, R.M., Gebel, H., Hauptfeld, V., Davie, J., and Lacy, P. Prevention of rejection of murine islet allografts by pretreatment with anti-dendritic cell antibody. Proc. Natl. Acad. Sci. USA. 81: 3864-3868, 1984https://digitalcommons.rockefeller.edu/historical-scientific-reports/1013/thumbnail.jp

Prevention of rejection of murine islet allografts by pretreatment with anti-dendritic cell antibody

Previously we have demonstrated that islets of Langerhans treated with donor-specific anti-Ia serum and complement survive when transplanted across the major histocompatibility complex of the mouse. In this study, using immunofluorescence, we demonstrate two morphologically distinct populations of Ia-positive cells scattered within the Ia-negative islet tissue. A large irregularly shaped Ia-positive subset of cells were identified as dendritic cells by using the 33D1 antibody specific for a mouse dendritic cell antigen. The other small, round Ia-positive subset was 33D1 negative. Islets pretreated with anti-dendritic cell antibody and complement prior to transplantation survived in their histoincompatible recipients for \u3e200 days. Rejection of stable islet allografts promptly occurred when transplant recipients were challenged with 1 x 105 donor dendritic cells 60 days after transplantation. These results demonstrate an important in vivo role for donor dendritic cells in the stimulation of allograft rejection

Correcting bias in self-rated quality of life: an application of anchoring vignettes and ordinal regression models to better understand QoL differences across commuting modes.

PURPOSE: Likert scales are frequently used in public health research, but are subject to scale perception bias. This study sought to explore scale perception bias in quality-of-life (QoL) self-assessment and assess its relationships with commuting mode in the Sydney Travel and Health Study. METHODS: Multilevel ordinal logistic regression analysis was used to analyse the association between two global QoL items about overall QoL and health satisfaction, with usual travel mode to work or study. Anchoring vignettes were applied using parametric and simpler nonparametric methods to detect and adjust for differences in reporting behaviour across age, sex, education, and income groups. RESULTS: The anchoring vignettes exposed differences in scale responses across demographic groups. After adjusting for these biases, public transport users (OR = 0.37, 95 % CI 0.21-0.65), walkers (OR = 0.44, 95 % CI 0.24-0.82), and motor vehicle users (OR = 0.47, 95 % CI 0.25-0.86) were all found to have lower odds of reporting high QoL compared with bicycle commuters. Similarly, the odds of reporting high health satisfaction were found to be proportionally lower amongst all competing travel modes: motor vehicle users (OR = 0.31, 95 % CI 0.18-0.56), public transport users (OR = 0.34, 95 % CI 0.20-0.57), and walkers (OR = 0.35, 95 % CI 0.20-0.64) when compared with cyclists. Fewer differences were observed in the unadjusted models. CONCLUSION: Application of the vignettes by the two approaches removed scaling biases, thereby improving the accuracy of the analyses of the associations between travel mode and quality of life. The adjusted results revealed higher quality of life in bicycle commuters compared with all other travel mode users

Structured benefit-risk assessment: a review of key publications and initiatives on frameworks and methodologies.

Introduction The conduct of structured benefit-risk assessment (BRA) of pharmaceutical products is a key area of interest for regulatory agencies and the pharmaceutical industry. However, the acceptance of a standardized approach and implementation are slow. Statisticians play major roles in these organizations, and have a great opportunity to be involved and drive the shaping of future BRA. Method We performed a literature search of recent reviews and initiatives assessing BRA methodologies, and grouped them to assist those new to BRA in learning, understanding, and choosing methodologies. We summarized the key points and discussed the impact of this emerging field on various stakeholders, particularly statisticians in the pharmaceutical industry. Results We provide introductory, essential, special interest, and further information and initiatives materials that direct readers to the most relevant materials, which were published between 2000 and 2013.  Based on recommendations in these materials we supply a toolkit of advocated BRA methodologies. Discussion Despite initiatives promoting these methodologies, there are still barriers, one of which being the lack of a consensus on the most appropriate methodologies among stakeholders. However, this opens up opportunities, for statisticians in the pharmaceutical industry especially, to champion appropriate BRA methodology use throughout the pharmaceutical product lifecycle. Conclusions This article may serve as a starting point for discussions and to reach a mutual consensus for methodology selection in a particular situation. Regulators and pharmaceutical industry should continue to collaborate to develop and take forward BRA methodologies, and by clear communication develop a mutual understanding of the key issues. Copyright © 2015 John Wiley & Sons, Ltd

Isopropanol at 60% and at 70% are effective against 'isopropanol-tolerant' Enterococcus faecium.

The bactericidal activity of isopropanol was determined against Enterococcus faecium ATCC 6057, ST 796 (isopropanol-tolerant strain) and Enterococcus hirae ATCC 10541 (EN 13727). Isopropanol at 60% and 70% were effective (≥5.38 log10-reduction) in 15 s against all strains but 23% isopropanol was not (<0.99 log10-reduction in ≤15 min). Isopropanol at 70% was tested against E. faecium in the four-field test. Eight millilitres was not effective enough in 1 min (<5 log10-reduction), whilst 16 mL was effective (≥5.85 log10-reduction). Healthcare workers can be reassured that 60% and 70% isopropanol with an appropriate volume are effective against E. faecium

Modelling of long term nitrogen retention in surface waters

In order to derive measures to reduce nutrient loadings into waters in Saxony, we calculated nitrogen inputs with the model STOFFBILANZ on the regional scale. Thereby we have to compare our modelling results to measured loadings at the river basin outlets, considering long term nutrient retention in surface waters. The most important mechanism of nitrogen retention is the denitrification in the contact zone of water and sediment, being controlled by hydraulic and micro-biological processes. Retention capacity is derived on the basis of the nutrient spiralling concept, using water residence time (hydraulic aspect) and time-specific N-uptake by microorganisms (biological aspect). Short time related processes of mobilization and immobilization are neglected, because they are of minor importance for the derivation of measures on the regional scale

The prevalence of loneliness across 113 countries: systematic review and meta-analysis.

OBJECTIVES: To identify data availability, gaps, and patterns for population level prevalence of loneliness globally, to summarise prevalence estimates within World Health Organization regions when feasible through meta-analysis, and to examine temporal trends of loneliness in countries where data exist. DESIGN: Systematic review and meta-analysis. DATA SOURCES: Embase, Medline, PsycINFO, and Scopus for peer reviewed literature, and Google Scholar and Open Grey for grey literature, supplemented by backward reference searching (to 1 September 2021) ELIGIBILITY CRITERIA FOR SELECTING STUDIES: Observational studies based on nationally representative samples (n≥292), validated instruments, and prevalence data for 2000-19. Two researchers independently extracted data and assessed the risk of bias using the Joanna Briggs Institute checklist. Random effects meta-analysis was conducted in the subset of studies with relatively homogeneous research methods by measurement instrument, age group, and WHO region. RESULTS: Prevalence data were available for 113 countries or territories, according to official WHO nomenclature for regions, from 57 studies. Data were available for adolescents (12-17 years) in 77 countries or territories, young adults (18-29 years) in 30 countries, middle aged adults (30-59 years) in 32 countries, and older adults (≥60 years) in 40 countries. Data for all age groups except adolescents were lacking outside of Europe. Overall, 212 estimates for 106 countries from 24 studies were included in meta-analyses. The pooled prevalence of loneliness for adolescents ranged from 9.2% (95% confidence interval 6.8% to 12.4%) in South-East Asia to 14.4% (12.2% to 17.1%) in the Eastern Mediterranean region. For adults, meta-analysis was conducted for the European region only, and a consistent geographical pattern was shown for all adult age groups. The lowest prevalence of loneliness was consistently observed in northern European countries (2.9%, 1.8% to 4.5% for young adults; 2.7%, 2.4% to 3.0% for middle aged adults; and 5.2%, 4.2% to 6.5% for older adults) and the highest in eastern European countries (7.5%, 5.9% to 9.4% for young adults; 9.6%, 7.7% to 12.0% for middle aged adults; and 21.3%, 18.7% to 24.2% for older adults). CONCLUSION: Problematic levels of loneliness are experienced by a substantial proportion of the population in many countries. The substantial difference in data coverage between high income countries (particularly Europe) and low and middle income countries raised an important equity issue. Evidence on the temporal trends of loneliness is insufficient. The findings of this meta-analysis are limited by data scarcity and methodological heterogeneity. Loneliness should be incorporated into general health surveillance with broader geographical and age coverage, using standardised and validated measurement tools. SYSTEMATIC REVIEW REGISTRATION: PROSPERO CRD42019131448

The PRIMAP-hist national historical emissions time series

To assess the history of greenhouse gas emissions and individual countries' contributions to emissions and climate change, detailed historical data are needed. We combine several published datasets to create a comprehensive set of emissions pathways for each country and Kyoto gas, covering the years 1850 to 2014 with yearly values, for all UNFCCC member states and most non-UNFCCC territories. The sectoral resolution is that of the main IPCC 1996 categories. Additional time series of CO2 are available for energy and industry subsectors. Country-resolved data are combined from different sources and supplemented using year-to-year growth rates from regionally resolved sources and numerical extrapolations to complete the dataset. Regional deforestation emissions are downscaled to country level using estimates of the deforested area obtained from potential vegetation and simulations of agricultural land. In this paper, we discuss the data sources and methods used and present the resulting dataset, including its limitations and uncertainties. The dataset is available from doi:10.5880/PIK.2016.003 and can be viewed on the website accompanying this paper (http://www.pik-potsdam.de/primap-live/primap-hist/)

Disappeared by Climate Change. The Shepherd Cultures of Qulban Ceni Murra (2nd Half of the 5th Millennium bc) and their Aftermath

Le phénomène funéraire attesté dans le sud-est de la Jordanie témoigne d’une phase d’occupation méconnue de la région au cours du milieu de l’Holocène, en lien avec un mode de vie pastoral basé sur l’exploitation des ressources en eau des puits (« Early Mid-Holocene pastoral well cultures », 4500-4000 bc). À titre d’hypothèse, cette phase précoce d’occupation a pu aboutir au développement des premières « cultures des oasis » de la péninsule Arabique (« Oasis cultures », 4000-35000/3000 bc). Cette deuxième phase constitue, après la Néolithisation, un des derniers grands épisodes de sédentarisation des sociétés du Proche-Orient, reflet d’une importante capacité d’innovation et d’adaptation socio-économique permettant la conquête de nouveaux territoires arides pour une occupation sédentaire. L’occupation pastorale du Sud-Est jordanien constitue le prolongement oriental du phénomène de peuplement de la péninsule Arabique, caractérisé au cours de la période (acéramique) du Chalcolithique récent/Bronze ancien par la récurrence des structures funéraires mégalithiques de pierres dressées et des cairns. Le site de Qulban Beni Murra est l’un de ces complexes funéraires importants (>1 km2), et témoigne d’une grande diversité dans les types de tombes et de structures en présence. Il atteste aussi une série d’aménagements hydrauliques (dépressions creusées) alimentés par des puits (datés de 4400 av. J.-C. environ) qui sont le reflet d’une occupation pastorale qui a probablement abouti au développement dans cette région, après un assèchement du climat à partir de 4000, d’une économie basée sur l’exploitation des oasis, là où les ressources en eau étaient encore disponibles.Sepulchral landscapes in southeastern Jordan give evidence of hitherto unknown early Mid-Holocene pastoral well cultures (4500-4000 bc), possibly followed by the region’s transition to an oasis-type of life-mode, or its contact to Arabia’s earliest oases cultures (4000-3500/3000 bc). The latter represents the latest major episode of sedentarisation in the Middle East and has to be considered as the most innovative and adaptive socioeconomic paradigm after the Neolithisation, allowing for sedentary use of arid lands from then on. The (aceramic) Late Chalcolithic/Early Bronze Age of Jordan’s southeast appears to be part of the western fringe of the pastoral well cultures that once occupied all of the Arabian Peninsula, characterised by their extensive megalithic standing stone graves and cairn fields. Qulban Beni Murra was not only such a large sepulchral centre (>1 km2) with several structural types of burials and other built features; its series of watering complexes (troughs), fed by wells (dating around 4400 bc), gives testimony to a lake/well-based pastoralism that probably became the progenitor of well-based oases economies at hydrologically favoured spots after the climate got drier and colder from 4000 bc on.تشير مخلفات القبور في منطقة جنوب شرق الأردن الى ثقافات بدوية غير معروفة حتى اليوم ارتبطت بأبار المياه خلال الفترة المتوسطة من عصر الهولوسين, والتي ربما تبعها تحول في المنطقة الى نمط حياة الواحات او التواصل مع ثقافات الواحات المبكرة في الجزيرة العربية (4000-3500/3000 ق.م). ويمثل هذا الأخير أحدث حلقة من التوطين في الشرق الأوسط والتي يجب أن تعتبر النموذج الأكثر ابتكاراً وتكيفا اجتماعياً واقتصادياً بعد العصر الحجري الحديث، مما سمح بالإستقرار في الأراضي القاحلة واستخدامها منذ ذلك الحين. ويبدو أن جنوب شرق الأردن خلال الفترة المتأخرة من العصر الحجري النحاسي وبداية العصر البرونزي المبكر كانت جزءاً من الطرف الغربي لثقافة البدواة المعتمدة على ابار المياه والتي سكنت مناطق الجزيرة العربية وتميزت بمخلفات القبور والرجوم التي تحتوي على الحجارة المنتصبة. ومنطقة قلبان بني مرة لا تحتوي فقط على المقابر الحجرية والتي تغطي واحد كيلومتر مربع ومعالم مبنية اخرى بل تحتوي كذلك على سلسلة من المناطق المروية التي تغذيها الأبار وتؤرخ الى حوالي 4400 ق.م. وهذا يشير الى وجود البداوة التي اعتمدت على البئر او البحيرة كنظام سابق لإقتصاد الواحات والتي فضلت مناطق معينة خلال الفترات الجافة والرطبة بعد 4000 ق.م