750 research outputs found
Building networks to strengthen research data management advocacy and training
University College London (UCL) is a research-intensive university with 380
research departments, units, institutes and centres that are home to 12,000
research staff and research students. The university has been at the forefront
of delivering open access to research publications through Discovery, the
institutional publications repository. In August 2013 the Research Data
Executive Services Group published a Research Data Policy outlining the
responsibilities of research staff and students and describing the variety of
institutional services that are available to support Research Data Management
(RDM). UCL’s Research Data Policy is supported by two Research Data Support
Offi cers (RDSOs) who work as part of the Liaison and Support Services within
UCL Library Services and work on a regular basis with the Research Data
Service based in Research IT Services and a number of other central services.
This article will briefl y describe how the RDSOs have developed links with other
services in order to improve awareness of RDM services
Discovering Spike Patterns in Neuronal Responses
When a cortical neuron is repeatedly injected with the same fluctuating current stimulus (frozen noise) the timing of the spikes is highly precise from trial to trial and the spike pattern appears to be unique. We show here that the same repeated stimulus can produce more than one reliable temporal pattern of spikes. A new method is introduced to find these patterns in raw multitrial data and is tested on surrogate data sets. Using it, multiple coexisting spike patterns were discovered in pyramidal cells recorded from rat prefrontal cortex in vitro, in data obtained in vivo from the middle temporal area of the monkey (Buracas et al., 1998) and from the cat lateral geniculate nucleus (Reinagel and Reid, 2002). The spike patterns lasted from a few tens of milliseconds in vitro to several seconds in vivo. We conclude that the prestimulus history of a neuron may influence the precise timing of the spikes in response to a stimulus over a wide range of time scales
UCL researchers and their research data: practices, challenges & recommendations (Report on the 2016 RDM survey)
Liver function changes after transarterial chemoembolization in US hepatocellular carcinoma patients: The LiverT study
Background: The real-world incidence of chronic liver damage after transarterial chemoembolization (TACE) is unclear. LiverT, a retrospective, observational study, assessed liver function deterioration after a single TACE in real-world hepatocellular carcinoma (HCC) patients in US practice. Methods: Eligible HCC patients identified from Optum's integrated database using standard codes as having had an index TACE between 2010 and 2016 with no additional oncologic therapy in the subsequent 3 months. At least one laboratory value (bilirubin, albumin, aspartate transaminase [AST], alanine transaminase [ALT], international normalized ratio [INR]) was required at baseline and the acute ( 6429 days after TACE) and chronic (30-90 days after TACE) periods. Due to lack of universally accepted liver function deterioration criteria, clinically meaningful changes in laboratory parameters were pre-defined by authors (FP, RM, and SO). Results: Of the 3963 TACE patients, 572 were eligible for analyses. Deterioration of liver function from baseline occurred in the acute period and persisted in the chronic period (bilirubin 30 and 23%, albumin 52 and 31%, AST 44 and 25%, ALT 43 and 25%, INR 25 and 15%, respectively). In a subgroup analysis, a higher proportion of patients with diabetes had deterioration in AST and ALT. Conclusions: A clinically meaningful proportion of real-world HCC patients had deterioration of liver function-related laboratory values 30-90 days after a single TACE in modern US practice. Future electronic health record research may help determine causality. The present findings highlight the need for the careful selection of patients for TACE, which is important to help optimize the benefit of the overall HCC treatment course
The processing of color, motion, and stimulus timing are anatomically segregated in the bumblebee brain
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