7 research outputs found
Numerical investigation into a surface plasmon resonance sensor based on optical fiber microring
Monitoring changes in malaria epidemiology and effectiveness of interventions in Ethiopia and Uganda: Beyond Garki Project baseline survey
Association of Neonicotinoid Insensitivity with a Conserved Residue in the Loop D Binding Region of the Tick Nicotinic Acetylcholine Receptor
Neonicotinoid insecticides target nicotinic acetylcholine
receptors
(nAChR) in the nervous system of insects but are largely ineffective
against ticks. This study aimed to identify the molecular basis for
this insensitivity. A homology model of the nAChR binding domain was
generated on the basis of the crystal structure of an acetylcholine-binding
protein with the insecticide imidacloprid bound. We hypothesized that
tick β-subunits would differ at a critical residue (Arg81) in
their D loops. To test this, we sequenced nAChR genes from five tick
species and found that instead of the conserved arginine found in
insects, a glutamine was present in all the tick sequences