Properties of coatings based on carbon and nitrogen-doped carbon obtained using a pulsed vacuum arc method

Diamond-like carbon coatings on hard-alloy substrates, including coatings doped with nitrogen about 1.0 μm thick have been obtained using a pulse vacuum-arc method. Three types of coatings have been investigated: a carbon diamond-like coating (C), a carbon coating doped with nitrogen (C : N), and a composite coating based on (C : N + C) layer

ОПЫТ ПРИМЕНЕНИЯ БЕДАКВИЛИНА И ЛИНЕЗОЛИДА В КОМПЛЕКСНОМ ЛЕЧЕНИИ БОЛЬНОГО ТУБЕРКУЛЕЗОМ ЛЕГКИХ С ШИРОКОЙ ЛЕКАРСТВЕННОЙ УСТОЙЧИВОСТЬЮ M. TUBERCULOSIS

The article describes the clinical case of effective treatment of the tuberculosis patient suffering from extensive drug resistance of M. tuberculosis. It describes modern approaches to diagnostics and treatment of multiple drug resistant tuberculosis, the best chemotherapy regimen including new effective anti-tuberculosis drugs, supplemented by valve bronchial block, and demonstrates the feasibility of integral approach to treatment of tuberculosis.Представлено наблюдение эффективного лечения больного туберкулезом легких с широкой лекарственной устойчивостью M. tuberculosis. Показаны современные подходы к диагностике и лечению мультирезистентного туберкулеза, оптимальный режим химиотерапии, включающий новые эффективные противотуберкулезные препараты, дополненный клапанной бронхоблокацией, продемонстрирована целесообразность комплексности лечения туберкулеза

Widespread occurrence of distinct alkenones from Group I haptophytes in freshwater lakes: Implications for paleotemperature and paleoenvironmental reconstructions

Alkenones are C35-C42 polyunsaturated ketone lipids that are commonly employed to reconstruct changes in sea surface temperature. However, their use in coastal seas and saline lakes can be hindered by species-mixing effects. We recently hypothesized that freshwater lakes are immune to species-mixing effects because they appear to exclusively host Group I haptophyte algae, which produce a distinct distribution of alkenones with a relatively consistent response of alkenone unsaturation to temperature. To evaluate this hypothesis and explore the geographic extent of Group I haptophytes, we analyzed alkenones in sediment and suspended particulate matter samples from lakes distributed throughout the mid- and high latitudes of the Northern Hemisphere (n = 30). Our results indicate that Group I-type alkenone distributions are widespread in freshwater lakes from a range of different climates (mean annual air temperature range: -17.3-10.9 degrees C; mean annual precipitation range: 125-1657 mm yr(-1); latitude range: 40-81 degrees N), and are commonly found in neutral to basic lakes (pH > 7.0), including volcanic lakes and lakes with mafic bedrock. We show that these freshwater lakes do not feature alkenone distributions characteristic of Group II lacustrine haptophytes, providing support for the hypothesis that freshwater lakes are immune to species-mixing effects. In lakes that underwent temporal shifts in salinity, we observed mixed Group I/II alkenone distributions and the alkenone contributions from each group could be quantified with the RIK37 index. Additionally, we observed significant correlations of alkenone unsaturation (U-37(K)) with seasonal and mean annual air temperature with this expanded freshwater lakes dataset, with the strongest correlation occurring during the spring transitional season (U-37(K) = 0.029 * T - 0.49; r(2) = 0.60; p < 0.0001). We present new sediment trap data from two lakes in northern Alaska (Toolik Lake, 68.632 degrees N, 149.602 degrees W; lake E5, 68.643 degrees N, 149.458 degrees W) that demonstrate the highest sedimentary fluxes of alkenones in the spring transitional season, concurrent with the period of lake ice melt and isothermal mixing. Together, these data provide a framework for evaluating lacustrine alkenone distributions and utilizing alkenone unsaturation as a lake temperature proxy. (C) 2018 Elsevier B.V. All rights reserved

The primary cilium as a dual sensor of mechanochemical signals in chondrocytes

The primary cilium is an immotile, solitary, and microtubule-based structure that projects from cell surfaces into the extracellular environment. The primary cilium functions as a dual sensor, as mechanosensors and chemosensors. The primary cilia coordinate several essential cell signaling pathways that are mainly involved in cell division and differentiation. A primary cilium malfunction can result in several human diseases. Mechanical loading is sense by mechanosensitive cells in nearly all tissues and organs. With this sensation, the mechanical signal is further transduced into biochemical signals involving pathways such as Akt, PKA, FAK, ERK, and MAPK. In this review, we focus on the fundamental functional and structural features of primary cilia in chondrocytes and chondrogenic cells

EXPERIENCE OF USING BEDAQUILINE AND LINEZOLID IN THE INTEGRAL TREATMENT OF THE PULMONARY TUBERCULOSIS PATIENT WITH EXTENSIVE DRUG RESISTANCE OF M. TUBERCULOSIS

The article describes the clinical case of effective treatment of the tuberculosis patient suffering from extensive drug resistance of M. tuberculosis. It describes modern approaches to diagnostics and treatment of multiple drug resistant tuberculosis, the best chemotherapy regimen including new effective anti-tuberculosis drugs, supplemented by valve bronchial block, and demonstrates the feasibility of integral approach to treatment of tuberculosis

Phase transitions sequence in pyrochlore Cd

The infrared reflectivity of Cd2Nb2O7 single crystal was studied in the temperature interval of 10-540 K, together with complementary dielectric measurements. A ferroelectric soft mode was revealed above the ferroelectric phase transition at Tc = 196 K coupled with a central-mode type dispersion in the near-millimetre range. This proves the mixed displacive and order-disorder nature of the transition. Below Tc many new modes were detected due to lowering of the symmetry, especially below the previously suggested incommensurate transition at 85 K. Discussion of the possible phase transitions based on symmetry considerations is presented with the conclusion that the ferroelectric transition is proper with the $F_{1u}$ symmetry of the order parameter, whereas the intermediate ferroelastic transition is improper and triggered by the coupling with the ferroelectric order parameter

Studying the Properties of Composites with a Polyvinylchloride Matrix and Meadow-Grass-Hay Filler

Abstract: Polymer composites with a polyvinylchloride matrix and crushed meadow-grass-hay filler (MGHF) were obtained by hot pressing. The influence of the content of MGHF in a composition on its physicomechanical properties was researched. It was established that the increment of MGHF content in the composition of a composite leads to change in the values of its properties, most of which are not inferior to those of similar materials filled with wood flour. © 2022, Pleiades Publishing, Ltd