The Evolution of Collective Land Tenure Regimes in Pastoralist Societies: Lessons from Andean Countries

Much has been said about the importance of pastoralist livelihoods for the effective and sustainable use of drylands around the world. Yet, pastoralist societies are experiencing more pressures to their way of life than ever before. These pressures and changing trends are jeopardising pastoralist livelihoods as well as the sustainability of dryland resources. In the face of this challenging reality, this paper aims to analyse how land tenure regimes of pastoralist societies living in the Andean altiplano have transformed over the last 50 years. It also discusses the implications of these transformations for the sustainability of resource management in these areas, based on the premise that a better understanding of customary land tenure regimes can help to inform public policy and decision making.GRADEELLA projectPractical Actio

USAWC Strategy Research Project

A report discussing environmental issues such as resource scarcity and energy shortages

Effects of Delivering Guanidinoacetic Acid or Its Prodrug to the Neural Tissue: Possible Relevance for Creatine Transporter Deficiency

The creatine precursor guanidinoacetate (GAA) was used as a dietary supplement in humans with no adverse events. Nevertheless, it has been suggested that GAA is epileptogenic or toxic to the nervous system. However, increased GAA content in rodents affected by guanidinoacetate methyltransferase (GAMT) deficiency might be responsible for their spared muscle function. Given these conflicting data, and lacking experimental evidence, we investigated whether GAA affected synaptic transmission in brain hippocampal slices. Incubation with 11.5 \ub5M GAA (the highest concentration in the cerebrospinal fluid of GAMT-deficient patients) did not change the postsynaptic compound action potential. Even 1 or 2 mM had no effect, while 4 mM caused a reversible decrease in the potential. Guanidinoacetate increased creatine and phosphocreatine, but not after blocking the creatine transporter (also used by GAA). In an attempt to allow the brain delivery of GAA when there was a creatine transporter deficiency, we synthesized diacetyl guanidinoacetic acid ethyl ester (diacetyl-GAAE), a lipophilic derivative. In brain slices, 0.1 mM did not cause electrophysiological changes and improved tissue viability after blockage of the creatine transporter. However, diacetyl-GAAE did not increase creatine nor phosphocreatine in brain slices after blockage of the creatine transporter. We conclude that: (1) upon acute administration, GAA is neither epileptogenic nor neurotoxic; (2) Diacetyl-GAAE improves tissue viability after blockage of the creatine transporter but not through an increase in creatine or phosphocreatine. Diacetyl-GAAE might give rise to a GAA\u2013phosphoGAA system that vicariates the missing creatine\u2013phosphocreatine system. Our in vitro data show that GAA supplementation may be safe in the short term, and that a lipophilic GAA prodrug may be useful in creatine transporter deficiency

Creatine salts provide neuroprotection even after partial impairment of the creatine transporter

open6Creatine, a compound that is critical for energy metabolism of nervous cells, crosses the blood-brain barrier (BBB) and the neuronal plasma membrane with difficulty, and only using its specific transporter. In the hereditary condition where the creatine transporter is defective (creatine transporter deficiency) there is no creatine in the brain, and administration of creatine is useless lacking the transporter. The disease is severe and incurable. Creatine-derived molecules that could cross BBB and plasma membrane independently of the transporter might be useful to cure this condition. Moreover, such molecules could be useful also in stroke and other brain ischemic conditions. In this paper, we investigated three creatine salts, creatine ascorbate, creatine gluconate and creatine glucose. Of these, creatine glucose was ineffective after transporter block with guanidine acetic acid (GPA) administration. Creatine ascorbate was not superior to creatine in increasing tissue creatine and phosphocreatine content after transporter impairment, however even after such impairment it delayed synaptic failure during anoxia. Finally, creatine gluconate was superior to creatine in increasing tissue content of creatine after transporter block and slowed down PS disappearance during anoxia, an effect that creatine did not have. These findings suggest that coupling creatine to molecules having a specific transporter may be a useful strategy in creatine transporter deficiency. In particular, creatine ascorbate has effects comparable to those of creatine in normal conditions, while being superior to it under conditions of missing or impaired creatine transporter.openAdriano, E; Garbati, P; Salis, A; Damonte, G; Millo, E; Balestrino, MAdriano, ENRICO GIOVANNI; Garbati, Patrizia; Salis, Annalisa; Damonte, Gianluca; Millo, Enrico; Balestrino, Maurizi

Controlling Bureaucracies with Fire Alarms: Policy Instruments and Cross-Country Patterns

publication-status: In preparationThe political control of the bureaucracy is a major theme in public administration scholarship, particularly in delegation theory. There is a wide range of policy instruments suitable for the purpose of control. In practice, however, there are economic and political limitations to deploying the full arsenal of control tools. We explore the implications of the costs of control by examining cross-country patterns of fire alarms. We identify and categorize a set of control instruments and their rationale using accountability typologies. We then code the presence or absence of different instruments by drawing on an original dataset of 14 instruments in a population of 17 European countries. Using configurational analysis, we analyse cross-country patterns. In the conclusions, we reflect on the patterns identified, their implications for controlling bureaucracy in advanced democracies and the literature on administrative traditions. We finally propose how our empirical findings may be extended to further explanatory analyses.European Research Counci

Controlling Bureaucracies with Fire Alarms: Policy Instruments and Cross-Country Patterns

notes: This article is based on research carried out with the support of the European Research Council (ERC) grant (#230267) Analysis of Learning in Regulatory Governance, ALREG, directed by Claudio Radaelli. Dunlop and Radaelli gratefully acknowledge the support of the ERC. The dataset was coded and prepared by Dr Nicola Corkin, associate research fellow in ALREG. The authors would like to thank Dr Fabrizio De Francesco for his contribution to this part of the ALREG project. The authors wish to express their gratitude to the organisers and participants of the ‘Coping with Power Dispersion’ workshop at the University of Copenhagen, 13-14 December 2012. Previous versions of this paper were also presented at the UK Political Studies Association (PSA) annual conference in Cardiff, 25-27 March 2013, the International Research Society for Public Management (IRSPM) annual conference in Prague, 10-12 April 2013 and the Europe@LSE seminar, LSE, 5 December 2013. We are grateful to Federica Bicchi, Jens Blom-Hansen, Nicola Corkin, Matt Flinders, Fabrizio Gilardi, Gilles Jeannot, Mathias Koenig-Archibugi, Martin Lodge, Martino Maggetti, Rod Rhodes, Mark Thatcher and Koen Verhoest, the three special issue editors and two anonymous referees for their insightful comments on earlier drafts. The usual disclaimer applies.publication-status: Acceptedtypes: ArticleThe political control of the bureaucracy is a major theme in public administration scholarship, particularly in delegation theory. There is a wide range of policy instruments suitable for the purpose of control. In practice, however, there are economic and political limitations to deploying the full arsenal of control tools. We explore the implications of the costs of control by examining cross-country patterns of fire alarms. We identify and categorise a set of control instruments and their rationale using accountability typologies. We then code the presence or absence of different instruments by drawing on an original dataset of 14 instruments in a population of 17 European countries. Using configurational analysis, we analyse cross-country patterns. In the conclusions, we reflect on the patterns identified, their implications for controlling bureaucracy in advanced democracies and the literature on administrative traditions. We finally propose how our empirical findings may be extended to further explanatory analyses