Phase transitions and the internal noise structure of nonlinear Schr\"odi nger equation solitons

We predict phase-transitions in the quantum noise characteristics of systems described by the quantum nonlinear Schr\"odinger equation, showing them to be related to the solitonic field transition at half the fundamental soliton amplitude. These phase-transitions are robust with respect to Raman noise and scattering losses. We also describe the rich internal quantum noise structure of the solitonic fields in the vicinity of the phase-transition. For optical coherent quantum solitons, this leads to the prediction that eliminating the peak side-band noise due to the electronic nonlinearity of silica fiber by spectral filtering leads to the optimal photon-number noise reduction of a fundamental soliton.Comment: 10 pages, 5 figure

Quantum limits to center-of-mass measurements

We discuss the issue of measuring the mean position (center-of-mass) of a group of bosonic or fermionic quantum particles, including particle number fluctuations. We introduce a standard quantum limit for these measurements at ultra-low temperatures, and discuss this limit in the context of both photons and ultra-cold atoms. In the case of fermions, we present evidence that the Pauli exclusion principle has a strongly beneficial effect, giving rise to a 1/N scaling in the position standard-deviation -- as opposed to a $1/\sqrt{N}$ scaling for bosons. The difference between the actual mean-position fluctuation and this limit is evidence for quantum wave-packet spreading in the center-of-mass. This macroscopic quantum effect cannot be readily observed for non-interacting particles, due to classical pulse broadening. For this reason, we also study the evolution of photonic and matter-wave solitons, where classical dispersion is suppressed. In the photonic case, we show that the intrinsic quantum diffusion of the mean position can contribute significantly to uncertainties in soliton pulse arrival times. We also discuss ways in which the relatively long lifetimes of attractive bosons in matter-wave solitons may be used to demonstrate quantum interference between massive objects composed of thousands of particles.Comment: 12 pages, 6 figures. Submitted to PRA. Revised to include more references as well as a discussion of fermionic center-of-mas

A feasible "Kochen-Specker" experiment with single particles

We present a simple experimental scheme which can be used to demonstrate an all-or-nothing type contradiction between non-contextual hidden variables and quantum mechanics. The scheme, which is inspired by recent ideas by Cabello and Garcia-Alcaine, shows that even for a single particle, path and spin information cannot be predetermined in a non-contextual way.Comment: 4 pages, 3 figure

Considerations for the optimal management of antibiotic therapy in elderly patients

Objectives: To maximise efficacy and minimise toxicity, special considerations are required for antibiotic prescription in elderly patients. This review aims to provide practical suggestions for the optimal management of antibiotic therapy in elderly patients. Methods: This was a narrative review. A literature search of published articles in the last 15 years on antibiotics and elderly patients was performed using the Cochrane Library and PubMed electronic databases. The three priority areas were identified: (i) pharmacokinetics/pharmacodynamics (PK/PD) for optimising dosage regimens and route of administration; (ii) antibiotic dosages in some special subpopulations; and (iii) treatment considerations relating to different antibiotic classes and their adverse events. Results: Clinicians should understand the altered PK/PD of drugs in this population owing to co-morbid conditions and normal physiological changes associated with ageing. The body of evidence justifies the need for individualised dose selection, especially in patients with impaired renal and liver function. Clinicians should be aware of the major drug–drug interactions commonly observed in the elderly as well as potential side effects. Conclusion: Antibiotic therapy in the elderly requires a comprehensive approach, including strategies to improve appropriate antibiotic prescribing, limit their use for uncomplicated infections and ensure the attainment of an optimal PK/PD target. To this purpose, further studies involving the elderly are needed to better understand the PK of antibiotics. Moreover, it is necessary to assess the role therapeutic drug monitoring in guiding antibiotic therapy in elderly patients in order to evaluate its impact on clinical outcome

Constraining chemical transport PM_2.5 modeling outputs using surface monitor measurements and satellite retrievals: application over the San Joaquin Valley

Advances in satellite retrieval of aerosol type can improve the accuracy of near-surface air quality characterization by providing broad regional context and decreasing metric uncertainties and errors. The frequent, spatially extensive and radiometrically consistent instantaneous constraints can be especially useful in areas away from ground monitors and progressively downwind of emission sources. We present a physical approach to constraining regional-scale estimates of PM2.5, its major chemical component species estimates, and related uncertainty estimates of chemical transport model (CTM; e.g., the Community Multi-scale Air Quality Model) outputs. This approach uses ground-based monitors where available, combined with aerosol optical depth and qualitative constraints on aerosol size, shape, and light-absorption properties from the Multi-angle Imaging SpectroRadiometer (MISR) on the NASA Earth Observing System's Terra satellite. The CTM complements these data by providing complete spatial and temporal coverage. Unlike widely used approaches that train statistical regression models, the technique developed here leverages CTM physical constraints such as the conservation of aerosol mass and meteorological consistency, independent of observations. The CTM also aids in identifying relationships between observed species concentrations and emission sources.Aerosol air mass types over populated regions of central California are characterized using satellite data acquired during the 2013 San Joaquin field deployment of the NASA Deriving Information on Surface Conditions from Column and Vertically Resolved Observations Relevant to Air Quality (DISCOVER-AQ) project. We investigate the optimal application of incorporating 275&thinsp;m horizontal-resolution aerosol air-mass-type maps and total-column aerosol optical depth from the MISR Research Aerosol retrieval algorithm (RA) into regional-scale CTM output. The impact on surface PM2.5 fields progressively downwind of large single sources is evaluated using contemporaneous surface observations. Spatiotemporal R2 and RMSE values for the model, constrained by both satellite and surface monitor measurements based on 10-fold cross-validation, are 0.79 and 0.33 for PM2.5, 0.88 and 0.65 for NO3−, 0.78 and 0.23 for SO42−, 1.00 and 1.01 for NH4+, 0.73 and 0.23 for OC, and 0.31 and 0.65 for EC, respectively. Regional cross-validation temporal and spatiotemporal R2 results for the satellite-based PM2.5 improve by 30&thinsp;% and 13&thinsp;%, respectively, in comparison to unconstrained CTM simulations and provide finer spatial resolution. SO42− cross-validation values showed the largest spatial and spatiotemporal R2 improvement, with a 43&thinsp;% increase. Assessing this physical technique in a well-instrumented region opens the possibility of applying it globally, especially over areas where surface air quality measurements are scarce or entirely absent.</p

Generating and probing a two-photon Fock state with a single atom in a cavity

A two-photon Fock state is prepared in a cavity sustaining a "source mode " and a "target mode", with a single circular Rydberg atom. In a third-order Raman process, the atom emits a photon in the target while scattering one photon from the source into the target. The final two-photon state is probed by measuring by Ramsey interferometry the cavity light shifts induced by the target field on the same atom. Extensions to other multi-photon processes and to a new type of micromaser are briefly discussed

Soliton back-action evading measurement using spectral filtering

We report on a back-action evading (BAE) measurement of the photon number of fiber optical solitons operating in the quantum regime. We employ a novel detection scheme based on spectral filtering of colliding optical solitons. The measurements of the BAE criteria demonstrate significant quantum state preparation and transfer of the input signal to the signal and probe outputs exiting the apparatus, displaying the quantum-nondemolition (QND) behavior of the experiment.Comment: 5 pages, 5 figure

Immunomodulatory parasites and toll-like receptor-mediated tumour necrosis factor alpha responsiveness in wild mammals

BACKGROUND: Immunological analyses of wild populations can increase our understanding of how vertebrate immune systems respond to 'natural' levels of exposure to diverse infections. A major recent advance in immunology has been the recognition of the central role of phylogenetically conserved toll-like receptors in triggering innate immunity and the subsequent recruitment of adaptive response programmes. We studied the cross-sectional associations between individual levels of systemic toll-like receptor-mediated tumour necrosis factor alpha responsiveness and macro- and microparasite infections in a natural wood mouse (Apodemus sylvaticus) population. RESULTS: Amongst a diverse group of macroparasites, only levels of the nematode Heligmosomoides polygyrus and the louse Polyplax serrata were correlated (negatively) with innate immune responsiveness (measured by splenocyte tumour necrosis factor alpha responses to a panel of toll-like receptor agonists). Polyplax serrata infection explained a strikingly high proportion of the total variation in innate responses. Contrastingly, faecal oocyst count in microparasitic Eimeria spp. was positively associated with innate immune responsiveness, most significantly for the endosomal receptors TLR7 and TLR9. CONCLUSION: Analogy with relevant laboratory models suggests the underlying causality for the observed patterns may be parasite-driven immunomodulatory effects on the host. A subset of immunomodulatory parasite species could thus have a key role in structuring other infections in natural vertebrate populations by affecting the 'upstream' innate mediators, like toll-like receptors, that are important in initiating immunity. Furthermore, the magnitude of the present result suggests that populations free from immunosuppressive parasites may exist at 'unnaturally' elevated levels of innate immune activation, perhaps leading to an increased risk of immunopathology

Cumulant expansion for studying damped quantum solitons

The quantum statistics of damped optical solitons is studied using cumulant-expansion techniques. The effect of absorption is described in terms of ordinary Markovian relaxation theory, by coupling the optical field to a continuum of reservoir modes. After introduction of local bosonic field operators and spatial discretization pseudo-Fokker-Planck equations for multidimensional s-parameterized phase-space functions are derived. These partial differential equations are equivalent to an infinite set of ordinary differential equations for the cumulants of the phase-space functions. Introducing an appropriate truncation condition, the resulting finite set of cumulant evolution equations can be solved numerically. Solutions are presented in Gaussian approximation and the quantum noise is calculated, with special emphasis on squeezing and the recently measured spectral photon-number correlations [Spaelter et al., Phys. Rev. Lett. 81, 786 (1998)].Comment: 17 pages, 13 figures, revtex, psfig, multicols, published in Phys.Rev.