Re-stating the post-political: depoliticization, social inequalities, and city-region growth

This paper argues that city-region building debates and relatedly ‘post-political’ literatures are missing critical perspectives on the state, particularly the state’s continued existence as a social relation and an arena for politics, its role in the regulation of uneven development and the conflicts and struggles that arise from this. The paper brings the state centrally into ‘post-political’ debates via a critical analysis of the interrelationships between depoliticization and neoliberalism. Focusing on Sheffield (South Yorkshire, England) in the context of devolution and deal-making public policy, the paper explores the seemingly consensual visionmaking dynamics of this city region and dissects the tensions around economic governance, welfare austerity and social inequalities to get a handle on the ‘postpolitical’ depoliticized state in, and of, contemporary capitalism

The city-region chimera: The political economy of metagovernance failure Britain

Within the context of spatial rebalancing and a Northern (metro-region) Powerhouse, this article explores the implementation of the devolution of employment and skills within the Sheffield city region. We make both an original empirical and analytical contribution by suggesting that notions of governance and metagovernance failure are important for analyzing the development, tensions and contradictions of city region economic governance within the context of the UK Government’s devolution and localism agenda (in particular “Devolution Agreements”). We consider that governance failure arises because of the primacy of a neoliberal-dominated strategy orientation towards the market and its failure in the delivery of skills. Governance and metagovernance mechanisms are unable to sufficiently coordinate effective responses to address a legacy of de-industrialisation, deep-rooted labour market and sociospatial inequalitie

Welfare through work and the re-regulation of labour markets in Denmark

This paper is positioned within theoretical perspectives that focus on welfare states as systems of power and negotiation between key social forces acting in and through the state apparatus. Despite an emerging consensus that UK welfare-state restructuring is deeply problematic, there appears to be reluctance, within the debate, to discuss viable alternatives to neoliberalism. In contrast to UK and North American strategies, Denmark has adopted a 'welfare-through-work' model, built around a more inclusive system of welfare reform. This article discusses its emergence, and focuses on the importance of Job Rotation as its leading-edge socio-economic strategy. It highlights recent conflicts and tensions within Job Rotation and, lastly, suggests lessons for the UK

On the Possibility of Anisotropic Curvature in Cosmology

In addition to shear and vorticity a homogeneous background may also exhibit anisotropic curvature. Here a class of spacetimes is shown to exist where the anisotropy is solely of the latter type, and the shear-free condition is supported by a canonical, massless 2-form field. Such spacetimes possess a preferred direction in the sky and at the same time a CMB which is isotropic at the background level. A distortion of the luminosity distances is derived and used to test the model against the CMB and supernovae (using the Union catalog), and it is concluded that the latter exhibit a higher-than-expected dependence on angular position. It is shown that future surveys could detect a possible preferred direction by observing ~ 20 / (\Omega_{k0}^2) supernovae over the whole sky.Comment: Extended SNe analysis and corrected some CMB results. Text also extended and references added. 8 pages, 5 figure

Altered collective mitochondrial dynamics in the Arabidopsis \u3ci\u3emsh1\u3c/i\u3e mutant compromising organelle DNA maintenance

Mitochondria form highly dynamic populations in the cells of plants (and almost all eukaryotes). The characteristics and benefits of this collective behaviour, and how it is influenced by nuclear features, remain to be fully elucidated. Here, we use a recently developed quantitative approach to reveal and analyse the physical and collective ‘social’ dynamics of mitochondria in an Arabidopsis msh1 mutant where the organelle DNA maintenance machinery is compromised. We use a newly created line combining the msh1 mutant with mitochondrially targeted green fluorescent protein (GFP), and characterize mitochondrial dynamics with a combination of single-cell time-lapse microscopy, computational tracking, and network analysis. The collective physical behaviour of msh1 mitochondria is altered from that of the wild type in several ways: mitochondria become less evenly spread, and networks of inter-mitochondrial encounters become more connected, with greater potential efficiency for inter-organelle exchange—reflecting a potential compensatory mechanism for the genetic challenge to the mitochondrial DNA population, supporting more inter-organelle exchange. We find that these changes are similar to those observed in friendly, where mitochondrial dynamics are altered by a physical perturbation, suggesting that this shift to higher connectivity may reflect a general response to mitochondrial challenges, where physical dynamics of mitochondria may be altered to control the genetic structure of the mtDNA population

Comparative report on the innovation groups

Work package four focuses on healthy organisations, defined as those that meet the dual needs of the organisation and its employees. The first phase involved individual interviews in one case study organisation in each partner country, examining workplace change and its impact on current quality of life. The second phase involved innovation groups, building on the interviews. This report focuses on the innovation groups. The aims of the innovation groups were: • to disseminate the analysis of the interviews to participants, • to address the challenges identified in this analysis in terms of the potential impacts on the dual agenda of enhancing quality of (working) life and workplace effectiveness, • to begin to engage participants in the collaborative development of small innovations that could help to meet these dual objectives

Distance-redshift from an optical metric that includes absorption

We show that it is possible to equate the intensity reduction of a light wave caused by weak absorption with a geometrical reduction in intensity caused by a "transverse" conformal transformation of the spacetime metric in which the wave travels. We are consequently able to modify Gordon's optical metric to account for electromagnetic properties of ponderable material whose properties include both refraction and absorption. Unlike refraction alone however, including absorption requires a modification of the optical metric that depends on the eikonal of the wave itself. We derive the distance-redshift relation from the modified optical metric for Friedman-Lema\^itre-Robertson-Walker spacetimes whose cosmic fluid has associated refraction and absorption coefficients. We then fit the current supernovae data and provide an alternate explanation (other than dark energy) of the apparent acceleration of the universe.Comment: 2 figure

Disruption of the N-alpha-Acetyltransferase NatB Causes Sensitivity to Reductive Stress in Arabidopsis thaliana

In Arabidopsis thaliana, the evolutionary conserved N-terminal acetyltransferase (Nat) complexes NatA and NatB co-translationally acetylate 60% of the proteome. Both have recently been implicated in the regulation of plant stress responses. While NatA mediates drought tolerance, NatB is required for pathogen resistance and the adaptation to high salinity and high osmolarity. Salt and osmotic stress impair protein folding and result in the accumulation of misfolded proteins in the endoplasmic reticulum (ER). The ER-membrane resident E3 ubiquitin ligase DOA10 targets misfolded proteins for degradation during ER stress and is conserved among eukaryotes. In yeast, DOA10 recognizes conditional degradation signals (Ac/N-degrons) created by NatA and NatB. Assuming that this mechanism is preserved in plants, the lack of Ac/N-degrons required for efficient removal of misfolded proteins might explain the sensitivity of NatB mutants to protein harming conditions. In this study, we investigate the response of NatB mutants to dithiothreitol (DTT) and tunicamycin (TM)-induced ER stress. We report that NatB mutants are hypersensitive to DTT but not TM, suggesting that the DTT hypersensitivity is caused by an over-reduction of the cytosol rather than an accumulation of unfolded proteins in the ER. In line with this hypothesis, the cytosol of NatB depleted plants is constitutively over-reduced and a global transcriptome analysis reveals that their reductive stress response is permanently activated. Moreover, we demonstrate that doa10 mutants are susceptible to neither DTT nor TM, ruling out a substantial role of DOA10 in ER-associated protein degradation (ERAD) in plants. Contrary to previous findings in yeast, our data indicate that N-terminal acetylation (NTA) does not inhibit ER targeting of a substantial amount of proteins in plants. In summary, we provide further evidence that NatB-mediated imprinting of the proteome is vital for the response to protein harming stress and rule out DOA10 as the sole recognin for substrates in the plant ERAD pathway, leaving the role of DOA10 in plants ambiguous

The Arabidopsis NOT4A E3 ligase promotes PGR3 expression and regulates chloroplast translation

Chloroplast function requires the coordinated action of nuclear- and chloroplast-derived proteins, including several hundred nuclear-encoded pentatricopeptide repeat (PPR) proteins that regulate plastid mRNA metabolism. Despite their large number and importance, regulatory mechanisms controlling PPR expression are poorly understood. Here we show that the Arabidopsis NOT4A ubiquitin-ligase positively regulates the expression of PROTON GRADIENT REGULATION 3 (PGR3), a PPR protein required for translating several thylakoid-localised photosynthetic components and ribosome subunits within chloroplasts. Loss of NOT4A function leads to a strong depletion of cytochrome b6f and NAD(P)H dehydrogenase (NDH) complexes, as well as plastid 30 S ribosomes, which reduces mRNA translation and photosynthetic capacity, causing pale-yellow and slow-growth phenotypes. Quantitative transcriptome and proteome analysis of the not4a mutant reveal it lacks PGR3 expression, and that its molecular defects resemble those of a pgr3 mutant. Furthermore, we show that normal plastid function is restored to not4a through transgenic PGR3 expression. Our work identifies NOT4A as crucial for ensuring robust photosynthetic function during development and stress-response, through promoting PGR3 production and chloroplast translatio