Instruction set mapping for performance optimization

Pe~ormunce optimization is the primary design goal in most digital signal processing (DSP) and numerically intensive applications. The problem of mapping high-level algorithmic descriptions for these applications to special-ized instruction sets has only recently begun to receive attention. In fact, the problem of optimizing performance has yet to be addressed directly. This paper introduces a new approach to instruction set mapping (and template matching in general) targeted toward pe~ormance optimi-zation. Several novel issues are addressed inc[uding par-tial matching and automatic clock selection.

Inactivation of the HIF-1 /PDK3 Signaling Axis Drives Melanoma toward Mitochondrial Oxidative Metabolism and Potentiates the Therapeutic Activity of Pro-Oxidants

International audienc

Foreign Interventions and Abuse of Civilians During the Peruvian Civil War

The international community has a declared intention to protect innocent civilians from direct and deliberate violence in civil conflicts, but its track record of actually doing so is mixed. Using a new monthly time-series data set, we explore the factors associated with variations in the number of civilians killed or wounded by participants in the civil war in Peru during the 1980s and 1990s. We find that an increase in the level of abuse by one side is strongly associated with subsequent increases in the level of abuse by the other. Certain types of foreign intervention had a large and statistically significant impact on the level of abuse; some types of intervention raised the level of violence, but others reduced it