Trap Door : Vitality Breaks in the Now Times

Trinh T. Minh-ha reminds us: “Between the twin chasms of navel-gazing and navel-erasing, the ground is narrow and slippery.” Comedy, lithe and sure-footed, is clever enough to traverse that ground. Not to move from A to B, but simply to move: to move on, to move out, to move from, to move in – to breathe movement where standing water threatens death. Comedy is life

Self-awareness of driving impairment in patients with cataract or glaucoma

This study compared the driving performance of individuals with the eye diseases cataracts or glaucoma with age-matched controls, as well as the individual’s own perceptions of driving. Participants included drivers over the age of 50 years who had been diagnosed with glaucoma (n=29) or cataracts (n=33) and a control group with no ocular pathology (n=13). Driving performance was measured on a closed road circuit using a range of standardised measures of vehicle control and hazard recognition and avoidance, while visual performance was measured with a battery of tests including visual acuity, contrast sensitivity and visual fields. Perceptions of vision and driving were assessed using the Activities of Daily Vision Scale, Driver Behaviour Questionnaire and a driving exposure questionnaire. Driving performance was significantly poorer (p<0.05) for each of the ocular disease groups compared to the control group. Impaired contrast sensitivity and the higher disease severity scores (for the glaucoma group only) correlated most strongly with poorer driving performance. While participants with cataracts rated their vision significantly more poorly than those in the glaucoma and control groups, there were no significant differences between the participant groups rating of their own driving performance. These findings suggest that there is no direct relationship between self-rated driving ability and actual vision and driving performance. This has serious road safety implications

Experimental study of the fluctuation theorem in a nonequilibrium steady state

The fluctuation theorem (FT) quantifies the probability of second law violations in small systems over short time scales. While this theorem has been experimentally demonstrated for systems that are perturbed from an initial equilibrium state, there are a number of studies suggesting that the theorem applies asymptotically in the long time limit to systems in a nonequilibrium steady state. The asymptotic application of the FT to such nonequilibrium steady states has been referred to in the literature as the steady-state fluctuation theorem (or SSFT). In this paper, we demonstrate experimentally the application of the FT to nonequilibrium steady states, using a colloidal particle localized in a translating optical trap. Furthermore, we show, for this colloidal system, that the FT holds under nonequilibrium steady states for all time, and not just in the long time limit, as in the SSFT

Quantitative analysis of ruminal methanogenic microbial populations in beef cattle divergent in phenotypic residual feed intake (RFI) offered contrasting diets

peer-reviewedBackground Methane (CH4) emissions in cattle are an undesirable end product of rumen methanogenic fermentative activity as they are associated not only with negative environmental impacts but also with reduced host feed efficiency. The aim of this study was to quantify total and specific rumen microbial methanogenic populations in beef cattle divergently selected for residual feed intake (RFI) while offered (i) a low energy high forage (HF) diet followed by (ii) a high energy low forage (LF) diet. Ruminal fluid was collected from 14 high (H) and 14 low (L) RFI animals across both dietary periods. Quantitative real time PCR (qRT-PCR) analysis was conducted to quantify the abundance of total and specific rumen methanogenic microbes. Spearman correlation analysis was used to investigate the association between the relative abundance of methanogens and animal performance, rumen fermentation variables and diet digestibility. Results Abundance of methanogens, did not differ between RFI phenotypes. However, relative abundance of total and specific methanogen species was affected (P < 0.05) by diet type, with greater abundance observed while animals were offered the LF compared to the HF diet. Conclusions These findings suggest that differences in abundance of specific rumen methanogen species may not contribute to variation in CH4 emissions between efficient and inefficient animals, however dietary manipulation can influence the abundance of total and specific methanogen species.Funding for the development and main work of this research was provided under the National Development Plan, through the Research Stimulus Fund, administered by the Department of Agriculture, Fisheries & Food, Ireland RSF 05 224

Evaluation of a new cropping option using a participatory approach with on-farm monitoring and simulation: a case study of spring-sown mungbeans

In the northern Australian cropping region, mungbean is commonly sown as an opportunity crop, usually on low soil water after a winter cereal, and consequently has a reputation for being a low yielding, high risk crop. Yield prospects could be improved and risks reduced if it was sown on soils with a higher soil water content, for instance in spring after a winter fallow. However, there is a lack of experience and confidence in alternative roles for mungbean in the farming system. This paper describes a research approach involving researchers, farmers, advisers, and grain traders in which on-farm monitoring of spring-sown commercial crops and cropping systems simulation with APSIM were used to explore yield prospects for a spring-sown crop after a winter fallow. The key elements of the approach are: (1) identification of possible options through simulation of scenarios, (2) testing the new practice with innovative farmers, and (3) monitoring of the management and performance of commercial crops and comparing yields with benchmarks estimated with a model. In this case, after 2 years of on-farm testing, spring-sown mungbean has been shown to have a potential for high returns in the northern cropping systems

A compact holographic optical tweezers instrument

Holographic optical tweezers have found many applications including the construction of complex micron-scale 3D structures and the control of tools and probes for position, force, and viscosity measurement. We have developed a compact, stable, holographic optical tweezers instrument which can be easily transported and is compatible with a wide range of microscopy techniques, making it a valuable tool for collaborative research. The instrument measures approximately 30×30×35 cm and is designed around a custom inverted microscope, incorporating a fibre laser operating at 1070 nm. We designed the control software to be easily accessible for the non-specialist, and have further improved its ease of use with a multi-touch iPad interface. A high-speed camera allows multiple trapped objects to be tracked simultaneously. We demonstrate that the compact instrument is stable to 0.5 nm for a 10 s measurement time by plotting the Allan variance of the measured position of a trapped 2 μm silica bead. We also present a range of objects that have been successfully manipulated

PIV Study of the Vortex Wake behind a Translationally Oscillating Cylinder in a Quiescent Fluid

The near wake produced by a circular cylinder oscillating translationally in a quiescent fluid or, alternatively, by oscillatory flow past a stationary cylinder at low Keulegan-Carpenter (KC) and Stokes (b) numbers has been investigated using Particle Image Velocimetry. All but one of the two- and three-dimensional regimes of the Tatsuno & Bearman [11] map were investigated. The findings are successfully compared with previous experimental observations and numerical simulations. Twodimensional Particle Image Velocimetry results of regime B show how the symmetrical pattern of vortices around the cylinder becomes three-dimensional. Additionally, the instantaneous results of regime E confirm that there is an intermittent change in the direction of the V-shaped vortices around the cylinder

Work probability distribution and tossing a biased coin

We show that the rare events present in dissipated work that enters Jarzynski equality, when mapped appropriately to the phenomenon of large deviations found in a biased coin toss, are enough to yield a quantitative work probability distribution for Jarzynski equality. This allows us to propose a recipe for constructing work probability distribution independent of the details of any relevant system. The underlying framework, developed herein, is expected to be of use in modelling other physical phenomena where rare events play an important role.Comment: 6 pages, 4 figures

Perivascular mast cells regulate vein graft neointimal formation and remodeling

Objective. Emerging evidence suggests an important role for mast cells in vein graft failure. This study addressed the hypothesis that perivascular mast cells regulate in situ vascular inflammatory and proliferative responses and subsequent vein graft neointimal lesion formation, using an optimized local mast cell reconstitution method. Methods and Results. Neointimal hyperplasia was induced by insertion of a vein graft into the right carotid artery in wild type and mast cell deficient KitW−sh/W−sh mice. In some experiments, mast cells were reconstituted systemically (tail vein injection of bone marrow-derived mast cells) or locally (directly into the right neck area) prior to vein grafting. Vein graft neointimal lesion formation was significantly (P &lt; 0.05) reduced in KitW−sh/W−sh mice. Mast cell deficiency reduced the number of proliferating cells, and inhibited L-selectin, CCL2, M-CSF and MIP-3α expression in the vein grafts. Local but not systemic mast cell reconstitution restored a perivascular mast cell population that subsequently promoted neointimal formation in mast cell deficient mice. Conclusion. Our data demonstrate that perivascular mast cells play a key role in promoting neointima formation by inducing local acute inflammatory and proliferative responses. These results suggest that ex vivo intraoperative targeting of mast cells may have therapeutic potential for the prevention of pathological vein graft remodeling