2,834 research outputs found
Micro-Computed Tomography Analysis of Subchondral Bone Regeneration Using Osteochondral Scaffolds in an Ovine Condyle Model
Osteochondral scaffold technology has emerged as a promising therapy for repairing osteochondral defects. Recent research suggests that seeding osteochondral scaffolds with bone marrow concentrate (BMC) may enhance tissue regeneration. To examine this hypothesis, this study examined subchondral bone regeneration in scaffolds with and without BMC. Ovine stifle condyle models were used for the in vivo study. Two scaffold systems (8 mm diameter and 10 mm thick) with and without BMC were implanted into the femoral condyle, and the tissues were retrieved after six months. The retrieved femoral condyles (with scaffold in) were examined using micro-computed tomography scans (micro-CT), and the micro-CT data were further analysed by ImageJ with respect to trabecular thickness, bone volume to total volume ratio (BV/TV) ratio, and degree of anisotropy of bone. Statistical analysis compared bone regeneration between scaffold groups and sub-set regions. These results were mostly insignificant (p < 0.05), with the exception of bone volume to total volume ratio when comparing scaffold composition and sub-set region. Additional trends in the data were observed. These results suggest that the scaffold composition and addition of BMC did not significantly affect bone regeneration in osteochondral defects after six months. However, this research provides data which may guide the development of future treatments
Bedded Pack Management System Case Study
Agribusiness, Agricultural Finance, Farm Management,
Scaling of heat transfer augmentation due to mechanical distortions in hypervelocity boundary layers
ALMA Observations of Asymmetric Molecular Gas Emission from a Protoplanetary Disk in the Orion Nebula
We present Atacama Large Millimeter/submillimeter Array (ALMA) observations
of molecular line emission from d216-0939, one of the largest and most massive
protoplanetary disks in the Orion Nebula Cluster (ONC). We model the spectrally
resolved HCO (4--3), CO (3--2), and HCN (4--3) lines observed at 0\farcs5
resolution to fit the temperature and density structure of the disk. We also
weakly detect and spectrally resolve the CS (7--6) line but do not model it.
The abundances we derive for CO and HCO are generally consistent with
expected values from chemical modeling of protoplanetary disks, while the HCN
abundance is higher than expected. We dynamically measure the mass of the
central star to be which is inconsistent with the
previously determined spectral type of K5. We also report the detection of a
spatially unresolved high-velocity blue-shifted excess emission feature with a
measurable positional offset from the central star, consistent with a Keplerian
orbit at . Using the integrated flux of the feature in
HCO (4--3), we estimate the total H gas mass of this feature to be at
least , depending on the assumed temperature. The
feature is due to a local temperature and/or density enhancement consistent
with either a hydrodynamic vortex or the expected signature of the envelope of
a forming protoplanet within the disk.Comment: 19 pages, 12 figures, accepted for publication in A
Radial Surface Density Profiles of Gas and Dust in the Debris Disk around 49 Ceti
We present ~0.4 resolution images of CO(3-2) and associated continuum
emission from the gas-bearing debris disk around the nearby A star 49 Ceti,
observed with the Atacama Large Millimeter/Submillimeter Array (ALMA). We
analyze the ALMA visibilities in tandem with the broad-band spectral energy
distribution to measure the radial surface density profiles of dust and gas
emission from the system. The dust surface density decreases with radius
between ~100 and 310 au, with a marginally significant enhancement of surface
density at a radius of ~110 au. The SED requires an inner disk of small grains
in addition to the outer disk of larger grains resolved by ALMA. The gas disk
exhibits a surface density profile that increases with radius, contrary to most
previous spatially resolved observations of circumstellar gas disks. While ~80%
of the CO flux is well described by an axisymmetric power-law disk in Keplerian
rotation about the central star, residuals at ~20% of the peak flux exhibit a
departure from axisymmetry suggestive of spiral arms or a warp in the gas disk.
The radial extent of the gas disk (~220 au) is smaller than that of the dust
disk (~300 au), consistent with recent observations of other gas-bearing debris
disks. While there are so far only three broad debris disks with well
characterized radial dust profiles at millimeter wavelengths, 49 Ceti's disk
shows a markedly different structure from two radially resolved gas-poor debris
disks, implying that the physical processes generating and sculpting the gas
and dust are fundamentally different.Comment: 20 pages, 8 figures, accepted for publication in ApJ March 31, 2017
(submitted Nov 2016
Expression of Drug Targets in Patients Treated with Sorafenib, Carboplatin and Paclitaxel
Introduction: Sorafenib, a multitarget kinase inhibitor, targets members of the mitogen-activated protein kinase (MAPK) pathway and VEGFR kinases. Here we assessed the association between expression of sorafenib targets and biomarkers of taxane sensitivity and response to therapy in pre-treatment tumors from patients enrolled in ECOG 2603, a phase III comparing sorafenib, carboplatin and paclitaxel (SCP) to carboplatin, paclitaxel and placebo (CP). Methods: Using a method of automated quantitative analysis (AQUA) of in situ protein expression, we quantified expression of VEGF-R2, VEGF-R1, VEGF-R3, FGF-R1, PDGF-Rβ, c-Kit, B-Raf, C-Raf, MEK1, ERK1/2, STMN1, MAP2, EB1 and Bcl-2 in pretreatment specimens from 263 patients. Results: An association was found between high FGF-R1 and VEGF-R1 and increased progression-free survival (PFS) and overall survival (OS) in our combined cohort (SCP and CP arms). Expression of FGF-R1 and VEGF-R1 was higher in patients who responded to therapy ((CR+PR) vs. (SD+PD+ un-evaluable)). Conclusions: In light of the absence of treatment effect associated with sorafenib, the association found between FGF-R1 and VEGF-R1 expression and OS, PFS and response might reflect a predictive biomarker signature for carboplatin/paclitaxel-based therapy. Seeing that carboplatin and pacitaxel are now widely used for this disease, corroboration in another cohort might enable us to improve the therapeutic ratio of this regimen. © 2013 Jilaveanu et al
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