КЛИНИКО-МОРФОЛОГИЧЕСКИЕ ОСОБЕННОСТИ НАСЛЕДСТВЕННОГО РАКА ЯИЧНИКА

Germ-line mutations in BRCA1 and BRCA2 genes are the most established risk factors for hereditary breast and ovarian cancers. The purpose of the study was to analyze BRCA1/2 testing in ovarian cancer patients. Materials and methods. We analyzed 222 patients with ovarian cancer (OC) who underwent genetic testing. Results. Recurrent Slavic mutations in these genes were detected in 60/222 (27%) patients.104 patients lacked any clinical signs of hereditary form of the disease, however BRCA1/2 genetic defects were identified among 11 (11%) of these women. BRCA1/2-associated carcinomas were characterized by more advanced stage at diagnosis and predominance of high-grade serous histological tumor subtype. Conclusion. These results emphasize the need for BRCA1/2 testing for all patients with OC. BRCA1/2-associated carcinomas have clinical and pathological cgaracteristics, which should be considered while planning therapy. Наследственные мутации в генах BRCA1 и BRCA2 являются наиболее известными и изученными факторами риска карцином молочной железы и яичника. Цель исследования – анализ опыта BRCA1/2- тестирования больных раком яичника. Материал и методы. Проанализированы данные 222 больных раком яичника (РЯ), направленных на генетическое тестирование. Результаты. Генетический дефект в генах BRCA1/2 был выявлен у 60 (27 %) из 222 пациенток. В группе женщин без клинических признаков наследственной формы заболевания генетические дефекты BRCA1/2 были обнаружены у 11 (11 %) из 104 пациенток. BRCA1/2-ассоциированные карциномы характеризовались более поздней стадией заболевания и преобладанием низкодифференцированного серозного гистологического типа опухоли. Заключение. BRCA1/2-ассоциированные опухоли составляют значимую часть злокачественных новообразований яичника, что обусловливает целесообразность генетического тестирования для всех пациенток с РЯ. BRCA1/2-ассоциированные карциномы имеют клинические и морфологические особенности, которые необходимо учитывать при планировании терапии.

Scintillation characteristics of the single crystalline CdWO₄ and Bi₄Ge₃O₁₂ compounds doped with mercury-like ions

Investigated are optical, luminescent and light-technical properties of the CdWO₄ and Bi₄Ge₃O₁₂ single crystals doped with mercury-like Bi³⁺ and Pb²⁺ impurities, respectively, with the aim of assertaining the possibility to match their spectral characteristics with a spectral sensitivity of semiconductor radiation detectors. It is established that the long-wave shift of the CdWO₄:Bi emission spectra and increase of the light yield in the sensitivity region of Si-PD up to 15-20% in comparison with this parameter for the CdWO₄, occuring at optimal level of the activator concentration 0.025–0.25 mass% Bi₂O₃ in the melt and contens of Li⁺ or Ag⁺ ions as compensators for providing the ratio of mentioned impurities not less than 1:(1.5÷3), is connected with emission of the (BiO₆⁹⁻) complexes with lmax = 560 nm and t = 0.8-4.2 µs at 300 K. The shift of the emission spectra of the Bi₄Ge₃O₁₂:Pb crystals into the red spectral region is caused by emission of the (PbO₆¹⁰⁻) complexes in the bands with lmax = 570 and 690 nm and t = 1.0 ms. In addition, the light yield of the Bi₄Ge₃O₁₂:Pb single crystals at impurity concentrations of 0.005–0.5 mass% PbO in the melt was not less than 1.0–0.8 in comparison with that of undoped analogs

CLINICAL AND MORPHOLOGICAL FEATURES OF HEREDITARY OVARIAN CANCER

Germ-line mutations in BRCA1 and BRCA2 genes are the most established risk factors for hereditary breast and ovarian cancers. The purpose of the study was to analyze BRCA1/2 testing in ovarian cancer patients. Materials and methods. We analyzed 222 patients with ovarian cancer (OC) who underwent genetic testing. Results. Recurrent Slavic mutations in these genes were detected in 60/222 (27%) patients.104 patients lacked any clinical signs of hereditary form of the disease, however BRCA1/2 genetic defects were identified among 11 (11%) of these women. BRCA1/2-associated carcinomas were characterized by more advanced stage at diagnosis and predominance of high-grade serous histological tumor subtype. Conclusion. These results emphasize the need for BRCA1/2 testing for all patients with OC. BRCA1/2-associated carcinomas have clinical and pathological cgaracteristics, which should be considered while planning therapy

Tests of FARICH prototype with precise photon position detection

In June 2012 a FARICH prototype from Philips Digital Photon Counting (PDPC) based on a photon camera with dimensions of 200×200 mm has been tested at CERN. Remarkable particle separation has been achieved with a 4-layer aerogel sample: the π /K separation at a 6 GeV/ c momentum is 3.5 σ , the μ/π separation is 5.3 σ at 1 GeV/ c . The analysis of the data has shown that the main contribution to the accuracy of the ring radius measurement comes from aerogel. The development of focusing aerogels is proceeding in two main directions: tuning of production technology of multilayer blocks and development of a new production method with continuous density (refractive index) gradient along the block depth. The beam test was carried out in December 2012–January 2013 at the electron beam test facility at the VEPP-4 M e + e − collider. The goal of this test was to measure different single layer and focusing aerogel samples, both multilayer and gradient. Aerogel samples were tested with a PDPC FARICH prototype. A part of DPC SPADs in each pixel was disabled to form an active area of 1×1 mm 2 . The collected data proved that gradient aerogel samples focus Cherenkov light