Effect logs of double diffusion on MHD Prandtl nano fluid adjacent to stretching surface by way of numerical approach

AbstractThe current communication is carried to contemplate the unique and novel characteristics of nanofluids by constructing formulation of Prandtl fluid model. The fascinating aspects of thermo diffusion effects are also accounted in this communication. Mathematical modelling is performed by employing boundary layer approach. Afterwards, similarity variables are selected to convert dimensional non-linear system into dimensionless expressions. The solution of governing dimensionless problem is executed by shooting method (SM). Graphical evaluation is displayed to depict the intrinsic behavior of embedded parameters on dimensionless velocity, temperature, solutal concentration and nanoparticle concentration profiles. Furthermore, the numerical variation for skin friction coefficient, local Nusselt number, Sherwood number and nano Sherwood number is scrutinized through tables. The assurance of current analysis is affirmed by developing comparison with previous findings available in literature, which sets a benchmark for implementation of computational approach. It is inferred from the computation that concentration profile increases whereas Sherwood number decreases for progressive values of Dufour solutal number

Chitosan-based bio-composite modified with thiocarbamate moiety for decontamination of cations from the aqueous media

Herein, we report the development of chitosan (CH)-based bio-composite modified with acrylonitrile (AN) in the presence of carbon disulfide. The current work aimed to increase the Lewis basic centers on the polymeric backbone using single-step three-components (chitosan, carbon disulfide, and acrylonitrile) reaction. For a said purpose, the thiocarbamate moiety was attached to the pendant functional amine (NH2) of chitosan. Both the pristine CH and modified CH-AN bio-composites were first characterized using numerous analytical and imaging techniques, including 13C-NMR (solid-form), Fourier-transform infrared spectroscopy (FTIR), elemental investigation, thermogravimetric analysis, and scanning electron microscopy (SEM). Finally, the modified bio-composite (CH-AN) was deployed for the decontamination of cations from the aqueous media. The sorption ability of the CH-AN bio-composite was evaluated by applying it to lead and copper-containing aqueous solution. The chitosan-based CH-AN bio-composite exhibited greater sorption capacity for lead (2.54 mmol g−1) and copper (2.02 mmol g−1) than precursor chitosan from aqueous solution based on Langmuir sorption isotherm. The experimental findings fitted better to Langmuir model than Temkin and Freundlich isotherms using linear regression method. Different linearization of Langmuir model showed different error functions and isothermal parameters. The nonlinear regression analysis showed lower values of error functions as compared with linear regression analysis. The chitosan with thiocarbamate group is an outstanding material for the decontamination of toxic elements from the aqueous environment251226CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQNão temThis research was funded by the academy of sciences for developing world (TWAS) and The Brazilian National Council for Scientific and Technological Development (CNPq) fellowship to AK. The APC was funded by MDPI, St. Alban-Anlage 66, 4052 Basel, Switzerlan

Engineering functionalized chitosan-based sorbent material : characterization and sorption of toxic elements

The present study reports the engineering of functionalized chitosan (CH)-based biosorbent material. Herein, a two-step reaction was performed to chemically modify the CH using 1,4-bis(3-aminopropyl) piperazine to incorporate nitrogen basic centers for cations sorption from the aqueous environment. The resultant functionalized chitosan-based sorbent material was designated as CH-ANP and characterized using various analytical techniques, including elemental analysis, Fourier-transform infrared spectroscopy (FTIR), 13C NMR (in solid-state), X-ray diffraction, and thermal analysis. Then, the newly engineered CH-ANP was employed for the removal of copper, lead, and cadmium in the aqueous medium. Langmuir sorption isotherm analysis revealed that the highest sorption abilities achieved were 2.82, 1.96, and 1.60 mmol g−1 for copper, cadmium, and lead, respectively. Linear and nonlinear regression methods were deployed on the sorption data to study the behavior of the Langmuir, the Freundlich, and the Temkin sorption isotherms. Among the four different forms, the Langmuir isotherm type 1 fit well to the experimental data as compared to the other models. It also showed the lowest values of error, and a higher correlation coefficient than the Freundlich and Temkin models; thus it was the best fit with the experimental data compared to the latter two models. In conclusion, the findings suggest that chemically modified novel materials with enhanced Lewis basic centers are useful and promising candidates for the sorption of various toxic cations in aqueous solution9235138CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQThis research was funded by The acadmey of sciences for developing world (TWAS) and The Brazilian National Council for Scientific and Technological Development (CNPq) fellowship to AK. The APC was funded by MDPI, St. Alban-Anlage 66, 4052 Basel, Switzerlan

Diversified Traditional Wooden Implements Used in Agriculture and Animal Husbandry Practices in Ladakh

The traditional wooden tools are the necessities of the daily life of the people of Ladakh region and are linked directly with geographical conditions of the region. A lot of diversity in the wooden tools used by the tribal farmers of Ladakh since ancient times is observed. The tools are made up of different, locally available materials in a unique fashion by the localites. These wooden implements are preferred over modern one’s because of their multipurpose uses. Secondly these traditional implements find wide applicability in the region because of steep terrain, where the scope of mechanized farm implements is very limited. In the present study few important traditional tools of Ladakh have been presented. The important tools viz; chepo, shak, zungba, rzgeem, saddle, khem, khaczhay, thougk, gourgur, butter churner, plough, smeing, rbhat, grookook etc. have been described in detail in this paper

Profiling reviewers’ social network strength and predicting the “Helpfulness” of online customer review

Online customer reviews have become a popular source of information that influences the purchasing decisions of many prospective customers. However, the rapidly increasing volume of online reviews presents a problem of information overload, which makes it difficult for customers to determine the quality of the reviews. This study defines the helpfulness of the reviews as a count variable and takes the review helpfulness prediction from both regression and classification perspectives. The influence of friends and followers on review helpfulness is examined by introducing Social Network Strength (SNS) features. Furthermore, the performance of Machine Learning (ML) algorithms and the importance of features are separately examined for both problems using different time span of reviews. The evaluation performed using a dataset of 90,671 Yelp shopping reviews demonstrates the effectiveness of the proposed approach. The findings of this study have important theoretical and practical implications for researchers, businesses, reviewers and review platforms

Antibacterial and Antifungal Activity of Methanolic Extracts of Salix alba L. Against Various Disease Causing Pathogens

The present study was aimed to manifest the antibacterial and antifungal activity of methanolic extracts of Salix alba L. against seven Gram-positive and Gram-negative bacterial pathogens e.g. Streptococcus pyogenes, Staphylococcus aureus (1), S. aureus (2), Shigella sonnei, Escherichia coli (1), E. coli (2) and Neisseria gonorrhoeae and three fungal isolates from the air such as Aspergillus terreus, A. ornatus, and Rhizopus stolonifer. Two different serotypes of S. aureus and E. coli were used. The agar well-diffusion method results showed the dose-dependent response of plant extracts against bacterial and fungal strains while some organisms were found resistant e.g. E. coli (1), S. sonnei, A. terreus and R. stolonifer. The highest antibacterial activity was recorded at 17.000±1.732 mm from 100 mg/mL of leaves methanolic extracts against S. pyogenes while the activity of most of the pathogens decreased after 24 h of incubation. The highest antifungal activity was reported at 11.833±1.0 mm against A. ornatus at 50 mg/mL after 48 h of the incubation period. These experimental findings endorse the use of S. alba in ethnopharmacological formulations and suggest the use of methanolic extracts of the said plant to develop drugs to control the proliferation of resistant disease causing pathogenic microbes

Cucurbitacin D exhibits potent anticancer activity in cervical cancer

In this study, we for the first time, investigated the potential anti-cancer effects of a novel analogue of cucurbitacin (Cucurbitacin D) against cervical cancer in vitro and in vivo. Cucurbitacin D inhibited viability and growth of cervical cancer cells (CaSki and SiHa) in a dose-dependent manner. IC50 of Cucurbitacin D was recorded at 400 nM and 250 nM in CaSki and SiHa cells, respectively. Induction of apoptosis was observed in Cucurbitacin D treated cervical cancer cells as measured by enhanced Annexin V staining and cleavage in PARP protein. Cucurbitacin D treatment of cervical cancer cells arrested the cell cycle in G1/S phase, inhibited constitutive expression of E6, Cyclin D1, CDK4, pRb, and Rb and induced the protein levels of p21 and p27. Cucurbitacin D also inhibited phosphorylation of STAT3 at Ser727 and Tyr705 residues as well as its downstream target genes c-Myc, and MMP9. Cucurbitacin D enhanced the expression of tumor suppressor microRNAs (miR-145, miRNA-143, and miRNA34a) in cervical cancer cells. Cucurbitacin D treatment (1 mg/kg body weight) effectively inhibited growth of cervical cancer cells derived orthotopic xenograft tumors in athymic nude mice. These results demonstrate the potential therapeutic efficacy of Cucurbitacin D against cervical cancer

Autophagic and endo-lysosomal dysfunction in neurodegenerative disease

Due to their post-mitotic state, metabolic demands and often large polarised morphology, the function and survival of neurons is dependent on an efficient cellular waste clearance system both for generation of materials for metabolic processes and removal of toxic components. It is not surprising therefore that deficits in protein clearance can tip the balance between neuronal health and death. Here we discuss how autophagy and lysosome-mediated degradation pathways are disrupted in several neurological disorders. Both genetic and cell biological evidence show the diversity and complexity of vesicular clearance dysregulation in cells, and together may ultimately suggest a unified mechanism for neuronal demise in degenerative conditions. Causative and risk-associated mutations in Alzheimer’s disease, Frontotemporal Dementia, Amyotrophic Lateral Sclerosis, Parkinson’s disease, Huntington’s disease and others have given the field a unique mechanistic insight into protein clearance processes in neurons. Through their broad implication in neurodegenerative diseases, molecules involved in these genetic pathways, in particular those involved in autophagy, are emerging as appealing therapeutic targets for intervention in neurodegeneration

Clinical Implications of Exosomes: Targeted Drug Delivery for Cancer Treatment

Exosomes are nanoscale vesicles generated by cells for intercellular communication. Due to their composition, significant research has been conducted to transform these particles into specific delivery systems for various disease states. In this review, we discuss the common isolation and loading methods of exosomes, some of the major roles of exosomes in the tumor microenvironment, as well as discuss recent applications of exosomes as drug delivery vessels and the resulting clinical implication