228 research outputs found
Natalizumab induced blood eosinophilia: A retrospective pharmacovigilance cohort study and review of the literature.
OBJECTIVE
To describe frequency of natalizumab related eosinophilia and clinical symptoms of eosinophilic disease in our monocentric cohort.
METHODS
Comparison of clinical characteristics of 115 natalizumab treated and 116 untreated RRMS patients and review of literature.
RESULTS
38% of natalizumab treated patients had eosinophilia, which occurred significantly more frequently compared to untreated MS patients (3%, p-value<0.001). In symptomatic patients, mean eosinophil counts were significantly higher than in asymptomatic patients and symptoms developed within one year.
DISCUSSION
Eosinophilia is a side effect of natalizumab and mostly asymptomatic. However, few patients develop within one year after start of natalizumab an eosinophilic disease as severe side effect
Collisionless Shock Acceleration of protons in a plasma slab produced in a gas jet by the collision of two laser-driven hydrodynamic shockwaves
We recently proposed a new technique of plasma tailoring by laser-driven
hydrodynamic shockwaves generated on both sides of a gas jet [J.-R. Marqu\`es
et al., Phys. Plasmas 28, 023103 (2021)]. In the continuation of this numerical
work, we studied experimentally the influence of the tailoring on proton
acceleration driven by a high-intensity picosecond-laser, in three cases:
without tailoring, by tailoring only the entrance side of the ps-laser, or both
sides of the gas jet. Without tailoring the acceleration is transverse to the
laser axis, with a low-energy exponential spectrum, produced by Coulomb
explosion. When the front side of the gas jet is tailored, a forward
acceleration appears, that is significantly enhanced when both the front and
back sides of the plasma are tailored. This forward acceleration produces
higher energy protons, with a peaked spectrum, and is in good agreement with
the mechanism of Collisionless Shock Acceleration (CSA). The spatio-temporal
evolution of the plasma profile was characterized by optical shadowgraphy of a
probe beam. The refraction and absorption of this beam was simulated by
post-processing 3D hydrodynamic simulations of the plasma tailoring. Comparison
with the experimental results allowed to estimate the thickness and
near-critical density of the plasma slab produced by tailoring both sides of
the gas jet. These parameters are in good agreement with those required for
CSA
- …