Comments on large-N volume independence

We study aspects of the large-N volume independence on R**3 x L**G, where L**G is a G-site lattice for Yang-Mills theory with adjoint Wilson-fermions. We find the critical number of lattice sites above which the center-symmetry analysis on L**G agrees with the one on the continuum S**1. For Wilson parameter set to one and G>=2, the two analyses agree. One-loop radiative corrections to Wilson-line masses are finite, reminiscent of the UV-insensitivity of the Higgs mass in deconstruction/Little-Higgs theories. Even for theories with G=1, volume independence in QCD(adj) may be guaranteed to work by tuning one low-energy effective field theory parameter. Within the parameter space of the theory, at most three operators of the 3d effective field theory exhibit one-loop UV-sensitivity. This opens the analytical prospect to study 4d non-perturbative physics by using lower dimensional field theories (d=3, in our example).Comment: 12 pages; added small clarifications, published versio

A Reversible Gene-Targeting Strategy Identifies Synthetic Lethal Interactions between MK2 and p53 in the DNA Damage Response In Vivo

A fundamental limitation in devising new therapeutic strategies for killing cancer cells with DNA damaging agents is the need to identify synthetic lethal interactions between tumor-specific mutations and components of the DNA damage response (DDR) in vivo. The stress-activated p38 mitogen-activated protein kinase (MAPK)/MAPKAP kinase-2 (MK2) pathway is a critical component of the DDR network in p53-deficient tumor cells in vitro. To explore the relevance of this pathway for cancer therapy in vivo, we developed a specific gene targeting strategy in which Cre-mediated recombination simultaneously creates isogenic MK2-proficient and MK2-deficient tumors within a single animal. This allows direct identification of MK2 synthetic lethality with mutations that promote tumor development or control response to genotoxic treatment. In an autochthonous model of non-small-cell lung cancer (NSCLC), we demonstrate that MK2 is responsible for resistance of p53-deficient tumors to cisplatin, indicating synthetic lethality between p53 and MK2 can successfully be exploited for enhanced sensitization of tumors to DNA-damaging chemotherapeutics in vivo.National Institutes of Health (U.S.) (Grant ES015339)National Institutes of Health (U.S.) (Grant GM60594)National Institutes of Health (U.S.) (Grant GM59281)National Institutes of Health (U.S.) (Grant CA112967)Janssen Pharmaceutical Ltd.Massachusetts Institute of Technology. Center for Environmental Health Sciences (Core Grant P30-CA14051)Massachusetts Institute of Technology. Center for Environmental Health Sciences (Core Grant ES-002109

Quantum limit of deterministic theories

We show that the quantum linear harmonic oscillator can be obtained in the large $N$ limit of a classical deterministic system with SU(1,1) dynamical symmetry. This is done in analogy with recent work by G.'t Hooft who investigated a deterministic system based on SU(2). Among the advantages of our model based on a non--compact group is the fact that the ground state energy is uniquely fixed by the choice of the representation.Comment: 4 pages, 2 figures, minor corrections added. To appear in the Proceedings of Waseda International Symposium on Fundamental Physics: "New Perspectives in Quantum Physics", 12-15 November 2002, Waseda University, Tokyo, Japa

Effective Kinetic Theory for High Temperature Gauge Theories

Quasiparticle dynamics in relativistic plasmas associated with hot, weakly-coupled gauge theories (such as QCD at asymptotically high temperature $T$) can be described by an effective kinetic theory, valid on sufficiently large time and distance scales. The appropriate Boltzmann equations depend on effective scattering rates for various types of collisions that can occur in the plasma. The resulting effective kinetic theory may be used to evaluate observables which are dominantly sensitive to the dynamics of typical ultrarelativistic excitations. This includes transport coefficients (viscosities and diffusion constants) and energy loss rates. We show how to formulate effective Boltzmann equations which will be adequate to compute such observables to leading order in the running coupling $g(T)$ of high-temperature gauge theories [and all orders in $1/\log g(T)^{-1}$]. As previously proposed in the literature, a leading-order treatment requires including both $22$ particle scattering processes as well as effective ``$12$'' collinear splitting processes in the Boltzmann equations. The latter account for nearly collinear bremsstrahlung and pair production/annihilation processes which take place in the presence of fluctuations in the background gauge field. Our effective kinetic theory is applicable not only to near-equilibrium systems (relevant for the calculation of transport coefficients), but also to highly non-equilibrium situations, provided some simple conditions on distribution functions are satisfied.Comment: 40 pages, new subsection on soft gauge field instabilities adde

Exponentiation of Multiparticle Amplitudes in Scalar Theories

It is argued that the amplitudes of the production of $n$ soft scalar particles by one or a few energetic ones in theories like $\lambda\phi^4$ has the exponential form, $A_n\propto\sqrt{n!}\exp[{1\over\lambda}F(\lambda n,\epsilon)]$, in the regime $\lambda\to 0$, $\lambda n={fixed}$, $\epsilon={fixed}$, where $\epsilon$ is the typical kinetic energy of outgoing particles. Existing results support this conjecture. Several new analytical and numerical results in favor of the exponential behavior of multiparticle amplitudes are presented.Comment: Revtex 3.0, 45 pages, 11 figures (some requires bezier.sty, two postscript figures appended after \end{document}), INR-866/9

Sphalerons in Two Higgs Doublet Theories

We undertake a comprehensive investigation of the properties of the sphaleron in electroweak theories with two Higgs doublets. We do this in as model-independent a way as possible: by exploring the physical parameter space described by the masses and mixing angles of the Higgs particles. If there is a large split in the masses of the neutral Higgs particles, there can be several sphaleron solutions, distinguished by their properties under parity and the behaviour of the Higgs field at the origin. In general, these solutions appear in parity conjugate pairs and are not spherically symmetric, although the departure from spherical symmetry is small. Including CP violation in the Higgs potential can change the energy of the sphaleron by up to 14 percent for a given set of Higgs masses, with significant implications for the baryogenesis bound on the mass of the lightest Higgs

Center clusters in the Yang-Mills vacuum

Properties of local Polyakov loops for SU(2) and SU(3) lattice gauge theory at finite temperature are analyzed. We show that spatial clusters can be identified where the local Polyakov loops have values close to the same center element. For a suitable definition of these clusters the deconfinement transition can be characterized by the onset of percolation in one of the center sectors. The analysis is repeated for different resolution scales of the lattice and we argue that the center clusters have a continuum limit.Comment: Table added. Final version to appear in JHE

Nexus solitons in the center vortex picture of QCD

It is very plausible that confinement in QCD comes from linking of Wilson loops to finite-thickness vortices with magnetic fluxes corresponding to the center of the gauge group. The vortices are solitons of a gauge-invariant QCD action representing the generation of gluon mass. There are a number of other solitonic states of this action. We discuss here what we call nexus solitons, in which for gauge group SU(N), up to N vortices meet a a center, or nexus, provided that the total flux of the vortices adds to zero (mod N). There are fundamentally two kinds of nexuses: Quasi-Abelian, which can be described as composites of Abelian imbedded monopoles, whose Dirac strings are cancelled by the flux condition; and fully non-Abelian, resembling a deformed sphaleron. Analytic solutions are available for the quasi-Abelian case, and we discuss variational estimates of the action of the fully non-Abelian nexus solitons in SU(2). The non-Abelian nexuses carry Chern-Simons number (or topological charge in four dimensions). Their presence does not change the fundamentals of confinement in the center-vortex picture, but they may lead to a modified picture of the QCD vacuum.Comment: LateX, 24 pages, 2 .eps figure

Operator Analysis for the Higgs Potential and Cosmological Bound on the Higgs-Boson Mass

Using effective lagrangian, we examine the impacts of new physics on the electroweak baryogenesis. By analysing the high dimensional operators relevent to the Higgs potential we point out that the Higgs mass bound required by electroweak baryogenesis can be relaxed to the region allowed by experiments, provided that new physics appears at the TeV scale.Comment: 10 Pages, Tex, UMDHEP 93-07

Electroweak bubbles and sphalerons

We consider non-perturbative solutions of the Weinberg-Salam model at finite temperature. We employ an effective temperature-dependent potential yielding a first order phase transition. In the region of the phase transition, there exist two kinds of static, spherically symmetric solutions: sphalerons and bubbles. We analyze these solutions as functions of temperature. We consider the most general spherically symmetric fluctuations about the two solutions and construct the discrete modes in the region of the phase transition. Sphalerons and bubbles both possess a single unstable mode. We present simple approximation formulae for these levels.Comment: 14 pages, plain tex, 9 figures appended as postscript files at the end of the paper. THU-93/0