20 research outputs found
DISTRIBUTION OF BIOCHEMICAL AND MOLECULAR-GENETIC MARKERS OF GENES IN WORKERS OF COAL MINING ENTERPRISES OF KUZBASS REGION SUFFERING FROM CHRONIC DUST BRONCHITIS
Distribution of genotypes of biochemical markers of HP, GC, EsD, ΠΡΠ genes, genotypes on polymorphic variants of the genes coding enzymes of biotransformation GSTT1 (GST-Ι΅1) and GSTM1 (GST-ΞΌ1) and NOS3 (VNTR4 polymorphism) in the miners with chronic mechanic bronchitis, and in persons without this occupational pathology is investigated. It is shown that the owners of EsD 1-2, ΠΡΠ bb genotypes are most subject to development of chronic mechanic bronchitis. Endogen factors of resistance to this disease are GC 1-1, EsD 1-1, ΠΡΠ bc genotypes
Association of COMT gene polymorphisms with Parkinson's disease
Parkinsonβs disease (PD) is one of the most serious and widespread neurodegenerative disorders. Genetic susceptibility plays a significant role in the development of PD.The aim of our study was to investigate associations between single nucleotide polymorphisms (SNPs) of the COMT gene coding dopamine catabolism enzyme and Parkinsonβs disease.Materials and methods. In this study seven SNPs (rs4680, rs6269, rs4633, rs4818, rs769224, rs165774, rs174696) of COMT were genotyped. 232 patients with PD and 127 healthy individuals in the Siberian region of Russia were examined. Venous blood samples were drawn as a marker of PD. Statistical differences in the prevalence of alleles and genotypes between groups of patients were assessed using IBM SPSS Statistics 23.1 software.Results. A significant association between the rs165774 polymorphism and PD was observed. Our study demonstrates that polymorphisms in the COMT gene may play an important role in the pathophysiology of Parkinsonβs disease
Profound Chemopreventative Effects of a Hydrogen Sulfide-Releasing NSAID in the APC(Min/+) Mouse Model of Intestinal Tumorigenesis
Canadian Institutes of Health Research grant to JL
Microarray study of single nucleotide polymorphisms and expression of ATP-binding cassette genes in breast tumors
Our previous research establishes that changes of expression of the ATP-binding cassette genes family is connected with the neoadjuvant chemotherapy effect. However, the mechanism of regulation of resistance gene expression remains unclear. As many researchers believe, single nucleotide polymorphisms can be involved in this process. Thereupon, microarray analysis is used to study polymorphisms in ATP-binding cassette genes. It is thus found that MDR gene expression is connected with 5 polymorphisms, i.e. rs241432, rs241429, rs241430, rs3784867, rs59409230, which participate in the regulation of expression of own genes
Geneticheskie markery i ikh vzaimosvyaz' s obmenom lipidov na etapakh razvitiya mikroangiopatiy u detey i podrostkov
Π¦Π΅Π»Ρ. ΠΠ·ΡΡΠ΅Π½ΠΈΠ΅ Π²Π·Π°ΠΈΠΌΠΎΡΠ²ΡΠ·ΠΈ Π³Π΅Π½Π΅ΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΌΠ°ΡΠΊΠ΅ΡΠΎΠ² Ρ ΡΠΎΡΡΠΎΡΠ½ΠΈΠ΅ΠΌ ΠΎΠ±ΠΌΠ΅Π½Π° Π»ΠΈΠΏΠΈΠ΄ΠΎΠ² Π½Π° ΡΡΠ°ΠΏΠ°Ρ
ΡΠ°Π·Π²ΠΈΡΠΈΡ ΠΌΠΈΠΊΡΠΎΠ°Π½Π³ΠΈΠΎΠΏΠ°ΡΠΈΠΉ Ρ Π΄Π΅ΡΠ΅ΠΉ ΠΈ ΠΏΠΎΠ΄ΡΠΎΡΡΠΊΠΎΠ² Ρ Π‘Π ΡΠΈΠΏΠ° 1. ΠΠ°ΡΠ΅ΡΠΈΠ°Π»Ρ ΠΈ ΠΌΠ΅ΡΠΎΠ΄Ρ. ΠΠ±ΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΎ 138 Π΄Π΅ΡΠ΅ΠΉ (73 ΠΌΠ°Π»ΡΡΠΈΠΊΠ° ΠΈ 65 Π΄Π΅Π²ΠΎΡΠ΅ΠΊ), Π±ΠΎΠ»ΡΠ½ΡΠ½ΡΡ
Π‘Π ΡΠΈΠΏΠ° 1. Π‘ΠΊΡΠΈΠ½ΠΈΠ½Π³ Π΄ΠΈΠ°Π±Π΅ΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΠ΅ΡΠΈΠ½ΠΎΠΏΠ°ΡΠΈΠΈ ΠΏΡΠΎΠ²ΠΎΠ΄ΠΈΠ»ΡΡ Ρ ΠΏΠΎΠΌΠΎΡΡΡ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ Π³Π»Π°Π·Π½ΠΎΠ³ΠΎ Π΄Π½Π° ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ ΠΏΡΡΠΌΠΎΠΉ ΠΎΡΡΠ°Π»ΡΠΌΠΎΡΠΊΠΎΠΏΠΈΠΈ ΠΏΠΎΡΠ»Π΅ ΡΠ°ΡΡΠΈΡΠ΅Π½ΠΈΡ Π·ΡΠ°ΡΠΊΠ°. ΠΡΠΎΠ²ΠΎΠ΄ΠΈΠ»ΠΈ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ Π»ΠΈΠΏΠΈΠ΄Π½ΠΎΠ³ΠΎ ΡΠΏΠ΅ΠΊΡΡΠ° ΠΊΡΠΎΠ²ΠΈ, ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΠ΅ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ Π°Π½Π³ΠΈΠΎΡΠ΅Π½Π·ΠΈΠ½ΠΏΡΠ΅Π²ΡΠ°ΡΠ°ΡΡΠ΅Π³ΠΎ ΡΠ΅ΡΠΌΠ΅Π½ΡΠ° ΡΡΠ²ΠΎΡΠΎΡΠΊΠΈ ΠΊΡΠΎΠ²ΠΈ ΠΈ ΠΌΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½ΠΎ-Π³Π΅Π½Π΅ΡΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΠΊΡΠΎΠ²ΠΈ. ΠΡΠ΄Π΅Π»Π΅Π½ΠΈΠ΅ ΡΠΎΡΠ°Π»ΡΠ½ΠΎΠΉ ΠΠΠ ΠΏΡΠΎΠ²ΠΎΠ΄ΠΈΠ»ΠΈ Ρ ΠΏΠΎΠΌΠΎΡΡΡ Π½Π΅ΡΠ½Π·ΠΈΠΌΠ°ΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΌΠ΅ΡΠΎΠ΄Π°. Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ. ΠΠ½Π°Π»ΠΈΠ· Π°ΡΡΠΎΡΠΈΠ°ΡΠΈΠΉ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ ?ΡΠ»ΡΡΠ°ΠΉ-ΠΊΠΎΠ½ΡΡΠΎΠ»Ρ? Π½Π΅ ΠΎΠ±Π½Π°ΡΡΠΆΠΈΠ» Π²Π»ΠΈΡΠ½ΠΈΡ Π½Π° ΡΠ°Π·Π²ΠΈΡΠΈΠ΅ Π΄ΠΈΠ°Π±Π΅ΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΌΠΈΠΊΡΠΎΠ°Π½Π³ΠΈΠΎΠΏΠ°ΡΠΈΠΉ Π’174Π ΠΏΠΎΠ»ΠΈΠΌΠΎΡΡΠΈΠ·ΠΌΠ° Π³Π΅Π½Π° AGT. Π‘ΡΠ°Π²Π½Π΅Π½ΠΈΠ΅ ΡΠ°ΡΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΡ Π³Π΅Π½ΠΎΡΠΈΠΏΠΎΠ² ΠΈ ΡΠ°ΡΡΠΎΡ Π°Π»Π»Π΅Π»Π΅ΠΉ Π’174Π ΠΏΠΎΠ»ΠΈΠΌΠΎΡΡΠΈΠ·ΠΌΠ° Π³Π΅Π½Π° AG T Ρ Π±ΠΎΠ»ΡΠ½ΡΡ
Π‘Π ΡΠΈΠΏΠ° 1 Π² Π·Π°Π²ΠΈΡΠΈΠΌΠΎΡΡΠΈ ΠΎΡ ΠΊΠΎΠΌΠΏΠ΅Π½ΡΠ°ΡΠΈΠΈ ΠΆΠΈΡΠΎΠ²ΠΎΠ³ΠΎ ΠΎΠ±ΠΌΠ΅Π½Π° ΠΏΠΎΠΊΠ°Π·Π°Π»ΠΎ, ΡΡΠΎ Π² Π³ΡΡΠΏΠΏΠ΅ Π±ΠΎΠ»ΡΠ½ΡΡ
Π‘Π ΡΠΈΠΏΠ° 1 Ρ ΡΠ΄ΠΎΠ²Π»Π΅ΡΠ²ΠΎΡΠΈΡΠ΅Π»ΡΠ½ΠΎΠΉ ΠΊΠΎΠΌΠΏΠ΅Π½ΡΠ°ΡΠΈΠ΅ΠΉ ΠΆΠΈΡΠΎΠ²ΠΎΠ³ΠΎ ΠΎΠ±ΠΌΠ΅Π½Π° ΠΏΡΠ΅ΠΎΠ±Π»Π°Π΄Π°Π΅Ρ Π°Π»Π»Π΅Π»Ρ Π’ (93 ΠΏΡΠΎΡΠΈΠ² 79%) ΠΈ ΡΠ΅ΠΆΠ΅ Π²ΡΡΡΠ΅ΡΠ°Π΅ΡΡΡ Π°Π»Π»Π΅Π»Ρ Π (7 ΠΏΡΠΎΡΠΈΠ² 21%) ΠΏΠΎ ΡΡΠ°Π²Π½Π΅Π½ΠΈΡ Ρ Π±ΠΎΠ»ΡΠ½ΡΠΌΠΈ Π‘Π ΡΠΈΠΏΠ° 1 Ρ Π½Π΅ΡΠ΄ΠΎΠ²Π»Π΅ΡΠ²ΠΎΡΠΈΡΠ΅Π»ΡΠ½ΠΎΠΉ ΠΊΠΎΠΌΠΏΠ΅Π½ΡΠ°ΡΠΈΠ΅ΠΉ ΠΆΠΈΡΠΎΠ²ΠΎΠ³ΠΎ ΠΎΠ±ΠΌΠ΅Π½Π°. ΠΡΠ²ΠΎΠ΄Ρ. ΠΠ°ΡΡΡΠ΅Π½ΠΈΡ Π»ΠΈΠΏΠΈΠ΄Π½ΠΎΠ³ΠΎ ΠΎΠ±ΠΌΠ΅Π½Π° Π² Π²ΠΈΠ΄Π΅ Π°ΡΠ΅ΡΠΎΠ³Π΅Π½Π½ΡΡ
ΠΏΡΠΎΡΠ²Π»Π΅Π½ΠΈΠΉ, ΠΏΠΎΠ²ΡΡΠ΅Π½ΠΈΡ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ ΠΠΠ€ ΡΠΏΠΎΡΠΎΠ±ΡΡΠ²ΡΡΡ ΡΠ°Π·Π²ΠΈΡΠΈΡ ΠΈ ΠΏΡΠΎΠ³ΡΠ΅ΡΡΠΈΡΠΎΠ²Π°Π½ΠΈΡ Π΄ΠΈΠ°Π±Π΅ΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΌΠΈΠΊΡΠΎΠ°Π½Π³ΠΈΠΎΠΏΠ°ΡΠΈΠΉ. ΠΠ±Π½Π°ΡΡΠΆΠ΅Π½Π° Π·Π°Π²ΠΈΡΠΈΠΌΠΎΡΡ Ρ ΠΌΠ΅ΠΆΠ΄Ρ ΡΡΠΆΠ΅ΡΡΡΡ Π‘Π ΡΠΈΠΏΠ° 1, ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»ΡΠΌΠΈ Π»ΠΈΠΏΠΈΠ΄Π½ΠΎΠ³ΠΎ ΠΎΠ±ΠΌΠ΅Π½Π° (Π₯Π‘ ΠΈ Π₯Π‘-ΠΠΠΠ ) ΠΈ Π’174Π ΠΏΠΎΠ»ΠΈΠΌΠΎΡΡΠΈΠ·ΠΌΠ° Π³Π΅Π½Π° AGT. ΠΠΎΠΌΠΎΠ·ΠΈΠ³ΠΎΡΡ Π’Π’ ΠΈΠΌΠ΅Π»ΠΈ Π±ΠΎΠ»Π΅Π΅ Π½ΠΈΠ·ΠΊΠΈΠΉ ΡΡΠΎΠ²Π΅Π½Ρ Π₯Π‘ ΠΈ Π₯Π‘-ΠΠΠΠ
Microarray study of single nucleotide polymorphisms and expression of ATP-binding cassette genes in breast tumors
Our previous research establishes that changes of expression of the ATP-binding cassette genes family is connected with the neoadjuvant chemotherapy effect. However, the mechanism of regulation of resistance gene expression remains unclear. As many researchers believe, single nucleotide polymorphisms can be involved in this process. Thereupon, microarray analysis is used to study polymorphisms in ATP-binding cassette genes. It is thus found that MDR gene expression is connected with 5 polymorphisms, i.e. rs241432, rs241429, rs241430, rs3784867, rs59409230, which participate in the regulation of expression of own genes