Chronic lymphocytic leukaemia: Up-dated recommendations on diagnosis and treatment

Diagnosis and treatment of chronic lymphatic leukaemia (CLL) are currently undergoing great change. New knowledge of prognosis factors and the numerous new therapeutic procedures now available, such as purine analogues, high-dose treatment and monoclonal antibodies are making major contributions to this progress. As a consequence, the options for treatment of CLL are considerably more diverse now than a few years ago, and now include procedures that take into account age and risk. At the same time, it should be emphasized that many important questions regarding the treatment of CLL remain unresolved. It is anticipated that these questions will be answered over the coming few years by including patients in multicentre studies like those being carried out by the German CLL study group

Coherent population transfer beyond the adiabatic limit: generalized matched pulses and higher-order trapping states

We show that the physical mechanism of population transfer in a 3-level system with a closed loop of coherent couplings (loop-STIRAP) is not equivalent to an adiabatic rotation of the dark-state of the Hamiltonian but coresponds to a rotation of a higher-order trapping state in a generalized adiabatic basis. The concept of generalized adiabatic basis sets is used as a constructive tool to design pulse sequences for stimulated Raman adiabatic passage (STIRAP) which give maximum population transfer also under conditions when the usual condition of adiabaticty is only poorly fulfilled. Under certain conditions for the pulses (generalized matched pulses) there exists a higher-order trapping state, which is an exact constant of motion and analytic solutions for the atomic dynamics can be derived.Comment: 15 pages, 9 figure

Gemini/GMOS Transmission Spectral Survey: Complete Optical Transmission Spectrum of the hot Jupiter WASP-4b

We present the complete optical transmission spectrum of the hot Jupiter WASP-4b from 440-940 nm at R ~ 400-1500 obtained with the Gemini Multi-Object Spectrometers (GMOS); this is the first result from a comparative exoplanetology survey program of close-in gas giants conducted with GMOS. WASP-4b has an equilibrium temperature of 1700 K and is favorable to study in transmission due to a large scale height (370 km). We derive the transmission spectrum of WASP-4b using 4 transits observed with the MOS technique. We demonstrate repeatable results across multiple epochs with GMOS, and derive a combined transmission spectrum at a precision about twice above photon noise, which is roughly equal to to one atmospheric scale height. The transmission spectrum is well fitted with a uniform opacity as a function of wavelength. The uniform opacity and absence of a Rayleigh slope from molecular hydrogen suggest that the atmosphere is dominated by clouds with condensate grain size of ~1 um. This result is consistent with previous observations of hot Jupiters since clouds have been seen in planets with similar equilibrium temperatures to WASP-4b. We describe a custom pipeline that we have written to reduce GMOS time-series data of exoplanet transits, and present a thorough analysis of the dominant noise sources in GMOS, which primarily consist of wavelength- and time- dependent displacements of the spectra on the detector, mainly due to a lack of atmospheric dispersion correction.Comment: 23 pages, 12 figures, accepted for publication in AJ, 2017 July

The Unpolarized Electrode in a Pulsating Poiseuille Pipe Flow

In recent years three workers have described methods of measurement of unsteady flow quantities in water using unpolarized electrodes. Both Binder and Chuang have attempted measurements of turbulent velocity fluctuations, whereas Dumargue described a method of fluctuating pressure measurement. In this paper, analysis and experiment were used to critically compare the previous workers\u27 experiments. From measurements in an oscillating Poiseuille pipe flow it is concluded that an electrode positioned in the wall detects a signal with a phase angle of π/4 ahead of the fluctuating velocity as measured by a hot-film probe in the pipe center. This is exactly the result predicted by theory for the velocity near the wall. Thus it may be inferred that in this configuration the unpolarized electrode is a velocity transducer and therefore substantiates the work of Binder and Chuang. Corrections are suggested for Binder\u27s and Chuang\u27s equations and it is deduced that the assumption made by all previous workers, namely that the charge density has a one-dimensional distribution depending only on the distance from the probe surface, could be in error. However, a one-dimensional charge distribution is necessary for Dumarque\u27s electrode to respond to pressure alone

Mean-field theory for Bose-Hubbard Model under a magnetic field

We consider the superfluid-insulator transition for cold bosons under an effective magnetic field. We investigate how the applied magnetic field affects the Mott transition within mean field theory and find that the critical hopping strength $(t/U)_c$, increases with the applied field. The increase in the critical hopping follows the bandwidth of the Hofstadter butterfly at the given value of the magnetic field. We also calculate the magnetization and superfluid density within mean field theory.Comment: 11 pages, 7 figures, published versio

Molecular heat pump for rotational states

In this work we investigate the theory for three different uni-directional population transfer schemes in trapped multilevel systems which can be utilized to cool molecular ions. The approach we use exploits the laser-induced coupling between the internal and motional degrees of freedom so that the internal state of a molecule can be mapped onto the motion of that molecule in an external trapping potential. By sympathetically cooling the translational motion back into its ground state the mapping process can be employed as part of a cooling scheme for molecular rotational levels. This step is achieved through a common mode involving a laser-cooled atom trapped alongside the molecule. For the coherent mapping we will focus on adiabatic passage techniques which may be expected to provide robust and efficient population transfers. By applying far-detuned chirped adiabatic rapid passage pulses we are able to achieve an efficiency of better than 98% for realistic parameters and including spontaneous emission. Even though our main focus is on cooling molecular states, the analysis of the different adiabatic methods has general features which can be applied to atomic systems

Cosmic String in Scalar-Tensor Gravity

The gravitational properties of a local cosmic string in the framework of scalar-tensor gravity are examined. We find the metric in the weak-field approximation and we show that, contrary to the General Relativity case, the cosmic string in scalar-tensor gravitation exerces a force on non-relativistic, neutral test particle. This force is proportional to the derivative of the conformal factor $A^{2}(\phi)$ and it is always attractive. Moreover, this force could have played an important role at the Early Universe, although nowadays it can be neglegible. It is also shown that the angular separation $\delta\varphi$ remains unaltered for scalar-tensor cosmic strings.Comment: 15 pages, LATEX, no figure

GPS observables in general relativity

I present a complete set of gauge invariant observables, in the context of general relativity coupled with a minimal amount of realistic matter (four particles). These observables have a straightforward and realistic physical interpretation. In fact, the technology to measure them is realized by the Global Positioning System: they are defined by the physical reference system determined by GPS readings. The components of the metric tensor in this physical reference system are gauge invariant quantities and, remarkably, their evolution equations are local.Comment: 6 pages, 1 figure, references adde