The Challenges of Psychological Adjustment for International Students: A Critical Analysis of Coping Mechanisms and Support Services

This paper critically analyzes the challenges of psychological adjustment faced by international students and explores coping mechanisms and support services that can help them overcome these challenges. The essay first introduces the background information on international students and highlights the importance of psychological adjustment for their well-being and academic success. The challenges of psychological adjustment, including cultural, academic, social adjustment, and language barrier, are discussed in detail. The essay then explores coping mechanisms, including problem-focused coping, emotion-focused coping, seeking social support, and cultural adjustment programs, and the support services, including counseling services and international student services, that can help international students adjust to their new environment. Finally, the essay evaluates the effectiveness of these coping mechanisms and support services, emphasizing the importance of cultural competence in providing effective support services. This essay has practical implications for higher education institutions in providing tailored support to international students and highlights the need for future research to explore the effectiveness of coping mechanisms and support services for different groups of international students and the impact of the COVID-19 pandemic on their psychological adjustment

The Effect of Social Isolation on the Mental Health of International Students

This paper looks into how social isolation affects international college students mental health. An increase in international students studying at colleges and universities abroad can be attributed to increased global mobility over the previous few decades. Because of this, these students struggle in certain ways to fit into their new academic and social surroundings. Among these difficulties, social isolation among overseas students has been recognized as a major issue. This essay will investigate how social isolation affects the mental health of international college students by drawing on existing studies. The various types of social isolation will be covered in the essay along with how they may affect mental health. It will also be looked at whether factors like linguistic difficulties, cultural shock, prejudice, and discrimination contribute to social isolation among overseas students. In light of the hazards to mental health posed by social isolation among international students, this presentation will offer some potential solutions. The findings of the inquiry will be utilized to create solutions that can assist overseas students in reducing the detrimental impacts of social isolation on their mental health. Compared to other groups, college students’ mental health has not been adequately researched, even though social isolation can be an emotionally and mentally damaging experience. The paper will focus on the various mental health impacts that international college students experience such as depression, anxiety, and long-term psychological harm. An analysis of existing literature on the topic, interviews with international college students, and the mental health resources available to this population are also discussed. The main findings of the research show that international college students living in a foreign country experience significant levels of social isolation due to language barriers and cultural differences

Substituted pyrazoles and their heteroannulated analogs—recent syntheses and biological activities

Pyrazoles are considered privileged scaffolds in medicinal chemistry. Previous reviews have discussed the importance of pyrazoles and their biological activities; however, few have dealt with the chemistry and the biology of heteroannulated derivatives. Therefore, we focused our attention on recent topics, up until 2020, for the synthesis of pyrazoles, their heteroannulated deriva-tives, and their applications as biologically active moieties. Moreover, we focused on traditional procedures used in the synthesis of pyrazoles

The role of nurses in diabetes care and the impact of the different approaches of nurses role on patients percieved quality of nursing care: two case studies from the UK and Kuwait

Type 2 diabetes (T2D) is considered as a global major health problem, which requires healthcare systems to find solutions to meet the needs of the great numbers of people with T2D. One key to these solutions is nurses who undertake the provision of diabetes care. Nursing care in T2D varies across countries as a result of differences in healthcare systems, the way in which they are organised and other factors relating to nursing practice. The UK and Kuwait are two countries which have high incidences of T2D but differing health care delivery models, which has raised the need to understand the different roles of nurses in providing T2D care in these two countries’ healthcare systems. Key aims of this research were: (1) to investigate the actual roles undertaken by nurses in T2D care; (2) to investigate the extent to which these different roles affect perceived quality of nursing care; (3) to investigate the guidelines of diabetes care in the UK and Kuwait; and (4) to evaluate if nurses are delivering care based on these guidelines. This study investigated two cases in the UK and Kuwait regarding nursing roles in T2D care and how they affect the perceived quality of nursing care. In order to understand the phenomenon, a multiple case study design was employed involving multiple sources of information including documents review, non-participant observations, and semi-structured interviews with nurses and their patients with T2D. The diabetes clinic sites for this study were Nottingham University Hospitals (NUH) Trust in the UK and the Ministry of Health (MoH) hospitals in Kuwait. A thematic approach was utilised as a framework for the within-case and cross-case analyses. The findings of the study showed that nurses are motivated and competent to provide optimum care to achieve patient satisfaction, which is a significant sign of quality of nursing care. The nurse-led system in the UK and the physician-led system in Kuwait indicate different approaches in T2D care. In the UK, the nurse’s part in T2D care has been extended and advanced, making the role comparable to a physician's role. For instance, the status of 'nurse consultant' and 'nurse prescriber', allows the nurse to coordinate and lead diabetes care. In Kuwait, nurses contribute significantly to T2D diabetes care; however, their role is not officially recognised as they are not titled ‘diabetes nurse’ despite the fact they follow physician-established guidelines. Findings from this research further showed that the role of a diabetes nurse in Kuwait lacks clarity, as evidenced by the lack of any published statements specifying their roles according to their specialisation, experience and qualifications. This absence of what nurses are supposed to be doing or a lack of a statement relating to the guideline-informed role of nurses has therefore resulted in an undervaluation and lack of support for this role in Kuwait. The results of this study enhanced understanding of the roles nurses play within T2D care in both the UK and Kuwait. The information gathered also provides better understanding about nurses’ guideline-informed roles and their actual roles in T2D care and therefore that data determines how the differences in the roles of nurses might impact on patients' perceived quality of nursing care

Methyl N-(2-bromo-4-chlorophenyl)carbamate

In the title molecule, C8H7BrClNO2, the bromochlorophenyl ring is inclined to the methylcarbamate unit by 32.73 (7). In the crystal, N—HO hydrogen bonds form chains of molecules parallel to [100]

Crystal structure of 1,1-dimethyl-3-(2-phenylethyl)urea, C11H16N2O

Abstract C11H16N2O, orthorhombic, Pbca (no. 61), a = 10.7388(6) Å, b = 9.8449(5) Å, c = 21.1259(14) Å, V = 2233.5(2) Å3, Z = 8, R gt (F) = 0.0582, wR ref (F 2) = 0.1795, T = 293 K.</jats:p

Design, Synthesis, Molecular Docking, Antiapoptotic and Caspase-3 Inhibition of New 1,2,3-Triazole/Bis-2(1H)-Quinolinone Hybrids

A series of novel 1,2,3-triazoles hybridized with two quinolin-2-ones, was designed and synthesized through click reactions. The structures of the synthesized compounds were elucidated by NMR, IR, and mass spectra in addition to elemental analysis. The synthesized compounds were assessed for their antiapoptotic activity in testis, as testicular torsion is the main cause of male infertility. This effect was studied in light of decreasing tissue damage induced by I/R in the testis of rats using N-acetylcysteine (NAC) as an antiapoptotic reference. Compounds 6a–c were the most active antiapoptotic hybrids with significant measurements for malondialdehyde (MDA) and total antioxidant capacity (TAC) and the apoptotic biomarkers (testicular testosterone, TNFα, and caspase-3) in comparison to the reference. A preliminary mechanistic study was performed to improve the antiapoptotic activity through caspase-3 inhibition. A compound assigned as 6-methoxy-4-(4-(((2-oxo-1,2-dihydroquinolin-4-yl)oxy)methyl)-1H-1,2,3-triazol-1-yl)quinolin-2(1H)-one (6c) was selected as a representative of the most active hybrids in comparison to NAC. Assay of cytochrome C for 6c revealed an attenuation of cytochrome C level about 3.54 fold, comparable to NAC (4.13 fold). In caspases-3,8,9 assays, 6c was found to exhibit more potency and selectivity toward caspase-3 than other caspases. The testicular histopathological investigation was carried out on all targeted compounds 6a–g, indicating a significant improvement in the spermatogenesis process for compounds 6a–c if compared to the reference relative to the control. Finally, molecular docking studies were done at the caspase-3 active site to suggest possible binding modes. Hence, it could conceivably be hypothesized that compounds 6a–c could be considered good lead candidate compounds as antiapoptotic agents

Design and synthesis of new thiazolidinone/uracil derivatives as antiproliferative agents targeting EGFR and/or BRAFV600E^{V600E}

Thiourea derivatives of uracil were efficiently synthesized via the reaction of 5-aminouracil with isothiocyanates. Then, we prepared uracil-containing thiazoles via condensation of thioureas with diethyl/dimethyl acetylenedicarboxylates. The structures of the products were confirmed by a combination of spectral techniques including infra-red (IR), nuclear magnetic resonance (NMR), mass spectrometry (MS) and elemental analyses. A rationale for the formation of the products is presented. The newly synthesized compounds were evaluated for their in vitro antiproliferative activity against four cancer cell lines. The compounds tested showed promising antiproliferative activity, with GI$_{50}$ values ranging from 1.10 µM to 10.00 µM. Compounds 3c, 5b, 5c, 5h, 5i, and 5j were the most potent derivatives, with GI$_{50}$ values ranging from 1.10 µM to 1.80 µM. Compound 5b showed potent inhibitory activity against EGFR and BRAF$^{V600E}$ with IC$_{50}$ of 91 ± 07 and 93 ± 08 nM, respectively, indicating that this compound could serve as a dual inhibitor of EGFR and BRAF$^{V600E}$ with promising antiproliferative properties. Docking computations revealed the great potency of compounds 5b and 5j towards EGFR and BRAF$^{V600E}$ with docking scores of −8.3 and −9.7 kcal/mol and −8.2 and −9.3 kcal/mol, respectively

Phishing websites detection by using optimized stacking ensemble model

Phishing attacks are security attacks that do not affect only individuals’ or organizations’ websites but may affect Internet of Things (IoT) devices and networks. IoT environment is an exposed environment for such attacks. Attackers may use thingbots software for the dispersal of hidden junk emails that are not noticed by users. Machine and deep learning and other methods were used to design detection methods for these attacks. However, there is still a need to enhance detection accuracy. Optimization of an ensemble classification method for phishing website (PW) detection is proposed in this study. A Genetic Algorithm (GA) was used for the proposed method optimization by tuning several ensemble Machine Learning (ML) methods parameters, including Random Forest (RF), AdaBoost (AB), XGBoost (XGB), Bagging (BA), GradientBoost (GB), and LightGBM (LGBM). These were accomplished by ranking the optimized classifiers to pick out the best classifiers as a base for the proposed method. A PW dataset that is made up of 4898 PWs and 6157 legitimate websites (LWs) was used for this study's experiments. As a result, detection accuracy was enhanced and reached 97.16 percent