30P Nowa fizyczna metoda wczesnego diagnozowania i monitorowania leczenia chorych z rozpoznaniem nowotworu

Pole magnetyczne o indukcji B > 10 tesli znajduje zastosowanie w analizie indukowanej dwójłomności kołowej surowicy krwi. Analiza oddziaływania silnego pola magnetycznego i elektromagnetycznego pola wiązki świetlnej z surowicą krwi wykazała, że w silnym polu magnetycznym ujawnia się wyraźnie ilościowa różnica magneto-optycznych efektów obserwowanych dla surowic dawców krwi chorych z nowotworami. Dokonano analizy 110 surowic krwi. Pomiary wykonano w silnym impulsowym (B ≅ 30 tesli). Próbki surowicy 23 dawców krwi zostały poddane badaniom mającym na celu określenie naturalnej aktywności optycznej. Surowice te stanowiły punkt odniesienia do analiz surowic chorych onkologicznych. Analizowano surowice chorych z rozpoznaniem raka prostaty, jelita grubego, raka jajnika, w którym w trakcie leczenia oznacza się poziom markerów nowotworowych. Druga grupa chorych to pacjenci z mierzalnymi guzami gruczołu piersiowego, mięsaka, czerniaka, szpiczaka. Dokonano pomiarów magneto-optycznych współczynników a, b, c oraz naturalnej aktywności optycznej α0 surowic.Wykazano wyraźną współzależność między stanem chorego, a wartością współczynnika b oraz jego korelacją ze wzrostem poziomu markerów nowotworowych lub wielkością ognisk przerzutowych. Prowadzone po raz pierwszy badania magnatyczno-optycznej dwójłomności kołowej surowicy są szybką metodą analityczną. Mogą w przyszłości mieć zastosowanie w diagnostyce i monitorowaniu leczenia nowotworów

Ecotoxicological assessment of mineralized stratum water as an environmentally friendly substitute for agrochemicals

Received: May 2nd, 2022 ; Accepted: July 17th, 2022 ; Published: July 28th, 2022 ; Correspondence: [email protected]; [email protected] a result of military operations on the territory of Ukraine, sown areas are reduced, the cost of plant protection products and fertilizers increases which emphasizes the problem of obtaining maximum yields from a smaller area of farmland. Given that a shortage of food grains can cause a global food crisis, research on the use of MSW as an environmentally friendly substitute for agrochemicals is relevant today. The aim of the research was to assess the ecotoxicological properties of MSW as an environmentally friendly substitute for synthetic agrochemicals. The impact of MSW as a fertilizer on soil chemical properties and assessment of MSW phytotoxicity as an herbicide for weeds and productivity of winter wheat were studied under field conditions. Toxicological assessment of MSW under laboratory conditions was carried out according to the following parameters: acute oral toxicity and resorptive-toxic effect of MSW. As a result of the assessment of MSW impact on soil chemical properties, it was found that significant soil acidification occurs only when MSW dose of more than 2,400 L ha-1 is used. The content of nitrates and oil products did not increase and there was no soil salinity when the MSW was used in doses of 300–1,200 L ha-1 . It was determined that the greatest decrease in weed plant biomass (85.5%) was observed when 100% concentration of MSW was used in a dose of 350 L ha-1 . As a consequence, with reduced weed infestation, there was a 21.5% increase in winter wheat yield if 100% MSW was used and a 19.1% increase if 75% MSW was used. As a result of the toxicological assessment of MSW, it was found that it belongs to low-toxic compounds. These results of ecotoxicological investigation of MSW make it possible to assert that its use is safe in agriculture, in particular as an environmentally safe organomineral fertilizer and herbicide

Life quality of the advanced ear cancer patient treated with combined radiotherapy and chemotherapy

A 43 years old woman was admitted to our hospital in July 1996 with large, ulcerated infiltration of the external, middle and internal ear. A cortical bone of the temporal pyramid was involved and destroyed from the inside of the skull.Cancer of the ear was preceded by a discoid lupus erythematodes lesion. Histopatologhical examination confirmed the diagnosis – keratinized squamous cell cancer.The patient was treated with radiation therapy (3 Gy per day, Co-60, isocentre technique, total dose of 54 Gy was delivered with two-week rest) and chemotherapy (MTX and BLEO once a week) concurrently.The follow up in January 1997 with CT examination revealed a small lesion in the external auditory meatus. The patient was proposed a wide surgical excision of the recurrence. She denied surgery and was irradiated using small fields, 2 Gy per fraction to the total dose of 14 Gy.Presently, the patient is living without pain. There is small pus discharge from the external auditory meatus. The lupus lesions in the irradiated volume are healed.In conclusion, the palliative radiotherapy was a reasonable alternative to the extensive surgical excision

1,8-Diamidocarbazoles: an easily tuneable family of fluorescent anion sensors and transporters

The synthesis, structure and anion recognition properties of an extensive, rationally designed series of bisamide derivatives of 1,8-diaminocarbazole and 1,8-diamino-3,6-dichlorocarbazole are described. Despite simple structures and the presence of only three hydrogen bond donors, such compounds are remarkably strong and selective receptors for oxyanions in DMSO + 0.5%H2O. Owing to their carbazole fluorophore, they are also sensitive turn-on fluorescent sensors for H2PO4− and AcO−, with a more than 15-fold increase in fluorescence intensity upon binding. Despite relatively weak chloride affinity, some of the diamidocarbazoles have also been shown, for the first time, to be very active chloride transporters through lipid bilayers. The binding, sensing and transport properties of these receptors can be easily modulated by the usually overlooked variations in the length and degree of branching of their alkyl side arms. Overall, this study demonstrates that the 1,8-diamidocarbazole binding unit is a very promising and synthetically versatile platform for the development of fluorescent sensors and transporters for anions.Polish National Science Centre for grant OPUS (2011/01/B/ST5/03900). The study was carried out at the Biological and Chemical Research Centre, University of Warsaw, established within a project co-financed by the European Union through the European Regional Development Fund under the Operational Programme Innovative Economy 2007–2013. R. Q. thanks financial support provided by Consejería de Educación – Junta de Castilla y León (Project BU092U16

71. The results of postoperative radiotherapy in 63 patients with low-grade gliomas treated in Greatpoland Cancer Center

IntroductionLow-grade glicomas represents 15% of all primary brain tumors.Material and MethodBetween 1990–97 63 patient with low-grade gliomas were treated in Greatpoland Cancer Center (39 males, 24 females; age between 20–60 year). 15 patients had andegrone complete surgical excision, 48 partial or subtotal excision of tumor. The frontal lobe was affected in 33 patients, the temporal lobe in 14 patients. Patients received conventional irradiaton of 60 Gy.Results*Five patients with histologically verified pilocytic astrocytomas(I) were treated after partial excision, median of age 29.2 year median survival 58 months (27–108). Only one patient died 27 months after radiotherapy. *Thirteen patients with fibrylar astrocytomas(II)-11 post subtotal excision-median age 37.7 year median survival 32.5 months. Recurrent tumor in two patients. Five patients are alive. *Ten patients with protoplasmatic astrocytoma(II)-7 post subtotal excision median of age 43.5 year median survival 30.8 months. Four patients alive. *Seven patients with gemistocytic astrocytomas(II) (6 post subtotal excision)-median age 36 year, median survival 32 months. Only one patient alive. *Eleven patients with oligoastrocytomas(II)-11 post subtotal excision, median age 38.6 year, median survival 43.9 months. Two patients with recrrent tumor. Alive 8 patients. *Seventeen patients with oligodendrogliomas (11 post subtotal excision) median age 39 years, median survival 39 months. One patien with recrrent tumor. Alive 8 patients.Conclusions*30 patients are alive(48%); *histopathologic diagnosis pilocytic astrocytomas asociated with age 10 years younger then either low-grade gliomas and long-term survivors; *poor prognistic factor in gemistocytic astrocytomas-only one patient alive; *five patients with recurrent tumor among 17 to 49 months after radiotheraphy

70. Meningiomas treated in Greatpoland Cancer Center between 1990–1997

IntroductionWe analyzed correlation between age of patient with anaplastic meningiomas, extension of tumor excision, histopatological recognition and time to recurrence and survival.Material and methodsBetween 1990–1997 7 patients with anaplastic meningioma, 3 patients with haemangiopericytoma, 2 patients with sarcoma meningeum (6 women and 6 men) have been irradiated. 7 patients underwent radical excision of the tumor, 5 patients non radical. The patients were irradiated from limited fields to total dose 56–60 Gy/T mostly by energy Co-60 (9 patients) and photons 9 MV (3 patients).ResultsThere are 6 patients with anaplasticum meningioma still alive. 3 patients living 96–108 months, 3 other 30–39 months. Recurrence was confirmed in two male participants who underwent radical surgery in 12 and 29 month from the start of treatment. The first patient died after 16 months with recurrence of the disease. One patient (39 years old) with heamangiopericytoma lives 40 months after radical surgery without evidence of recurrence. Two patients died – one 11 months after radical surgery (41 years old) and the other one (42 years old) 21 months after non radical surgery. Both patients (24 and 59 years old) with sarcoma died (one after 8 months, and the other one after 21 months).ConclusionsPatient with anaplastic meningiomas have long survival. The extension of tumor excision didn’t influence on survival