172 research outputs found
Id2-, RORγt-, and LTβR-independent initiation of lymphoid organogenesis in ocular immunity
The eye is protected by the ocular immunosurveillance system. We show that tear ductâassociated lymphoid tissue (TALT) is located in the mouse lacrimal sac and shares immunological characteristics with mucosa-associated lymphoid tissues (MALTs), including the presence of M cells and immunocompetent cells for antigen uptake and subsequent generation of mucosal immune responses against ocularly encountered antigens and bacteria such as Pseudomonas aeruginosa. Initiation of TALT genesis began postnatally; it occurred even in germ-free conditions and was independent of signaling through organogenesis regulators, including inhibitor of DNA binding/differentiation 2, retinoic acidârelated orphan receptor Îłt, lymphotoxin (LT) Îą1β2âLTβR, and lymphoid chemokines (CCL19, CCL21, and CXCL13). Thus, TALT shares immunological features with MALT but has a distinct tissue genesis mechanism and plays a key role in ocular immunity
The dominant human conjunctival epithelial CD8ιβ+ T cell population is maintained with age but the number of CD4+ T cells increases
Immune recognition of salivary proteins from the cattle tick Rhipicephalus microplus differs according to the genotype of the bovine host
Immunoblotting and Tear Sampling Techniques for the Study of Contact Lens-Induced Variations in Tear Protein Profiles
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