5,138 research outputs found
The millimeter and submillimeter laboratory spectrum of methyl formate in its ground symmetric torsional state
Over 200 rotational lines of methyl formate in its ground (v-t = 0), symmetric (A) torsional state have been measured in the frequency range 140-550 GHz. Analysis of these and lower frequency transitions permits accurate prediction (≤0.1 MHz) of over 10,000 transitions at frequencies below 600 GHz with angular momentum J ≤ 50. The measured spectral lines have permitted identification of over 100 new methyl formate lines in Orion
The laboratory millimeter-wave spectrum of methyl formate in its ground torsional E state
Over 250 rotational transitions of the internal rotor methyl formate (HCOOCH_3) in its ground v_t = 0 degenerate (E) torsional substate have been measured in the millimeter-wave spectral region. These data and a number of E-state lines identified by several other workers have been analyzed using an extension of the classical principal-axis method in the high barrier limit. The resulting rotational constants allow accurate prediction of the v_t = 0 E substate methyl formate spectrum below 300 GHz between states with angular momentum J ≤ 30 and rotational energy E_(rot)≤ 350cm^(-1). The calculated transition frequencies for the E state, when combined with the results of the previous analysis of the ground-symmetric, nondegenerate state, account for over 200 of the emission lines observed toward Orion in a recent survey of the 215-265 GHz band
Conditional Image-Text Embedding Networks
This paper presents an approach for grounding phrases in images which jointly
learns multiple text-conditioned embeddings in a single end-to-end model. In
order to differentiate text phrases into semantically distinct subspaces, we
propose a concept weight branch that automatically assigns phrases to
embeddings, whereas prior works predefine such assignments. Our proposed
solution simplifies the representation requirements for individual embeddings
and allows the underrepresented concepts to take advantage of the shared
representations before feeding them into concept-specific layers. Comprehensive
experiments verify the effectiveness of our approach across three phrase
grounding datasets, Flickr30K Entities, ReferIt Game, and Visual Genome, where
we obtain a (resp.) 4%, 3%, and 4% improvement in grounding performance over a
strong region-phrase embedding baseline.Comment: ECCV 2018 accepted pape
Noncontacting device to indicate deflection of turbopump internal rotating parts
Phase 2 (development) which was concluded for the ultrasonic Doppler device and the light-pipe-reflectance device is reported. An ultrasonic Doppler breadboard system was assembled which accurately measured runout in the J-2 LOX pump impeller during operation. The transducer was mounted on the outside of the pump volute using a C-clamp. Vibration was measured by conducting the ultrasonic wave through the volute housing and through the fluid in the volute to the impeller surface. The impeller vibration was also measured accurately using the light-pipe probe mounted in an elastomeric-gland fitting in the pump case. A special epoxy resin developed for cryogenic applications was forced into the end of the fiber-optic probe to retain the fibers. Subsequently, the probe suffered no damage after simultaneous exposure to 2150 psi and 77 F. Preliminary flash X-radiographs were taken of the turbine wheel and the shaft-bearing-seal assembly, using a 2-megavolt X-ray unit. Reasonable resolution and contrast was obtained. A fast-neutron detector was fabricated and sensitivity was measured. The results demonstrated that the technique is feasible for integrated-time measurements requiring, perhaps, 240 revolutions to obtain sufficient exposure at 35,000 rpm. The experimental verification plans are included
Direct Dark Matter Detection with Velocity Distribution in the Eddington approach
Exotic dark matter together with the vacuum energy (associated with the
cosmological constant) seem to dominate the Universe. Thus its direct detection
is central to particle physics and cosmology. Supersymmetry provides a natural
dark matter candidate, the lightest supersymmetric particle (LSP). One
essential ingredient in obtaining the direct detection rates is the density and
the velocity distribution of the LSP in our vicinity. In the present paper we
study simultaneously density profiles and velocity distributions in the context
of the Eddington approach. In such an approach, unlike the commonly assumed
Maxwell-Boltzmann (M-B) distribution, the upper bound of the velocity arises
naturally from the potential.Comment: 21 LaTex pages, 27 figure
Noncontacting devices to indicate deflection and vibration of turbopump internal rotating parts
Published report discusses feasibility of ultrasonic techniques; neutron techniques; X-radiography; optical devices; gamma ray devices; and conventional displacement sensors. Use of signal transmitters in place of slip rings indicated possible improvement and will be subject of futher study
Duration of intravenous antibiotic therapy in people with cystic fibrosis
Background
Progressive lung damage from recurrent exacerbations is the major cause of mortality and morbidity in cystic fibrosis. Life expectancy of people with cystic fibrosis has increased dramatically in the last 40 years. One of the major reasons for this increase is the mounting use of antibiotics to treat chest exacerbations caused by bacterial infections. The optimal duration of intravenous antibiotic therapy is not clearly defined. Individuals usually receive intravenous antibiotics for 14 days, but treatment may range from 10 to 21 days. A shorter duration of antibiotic treatment risks inadequate clearance of infection which could lead to further lung damage. Prolonged courses of intravenous antibiotics are expensive and inconvenient. The risk of systemic side effects such as allergic reactions to antibiotics also increases with prolonged courses and the use of aminoglycosides requires frequent monitoring to minimise some of their side effects. However, some organisms which infect people with cystic fibrosis are known to be multi‐resistant to antibiotics, and may require a longer course of treatment. This is an update of previously published reviews.
Objectives
To assess the optimal duration of intravenous antibiotic therapy for treating chest exacerbations in people with cystic fibrosis.
Search methods
We searched the Cochrane Cystic Fibrosis and Genetic Disorders Group Trials Register which comprises references identified from comprehensive electronic database searches, handsearches of relevant journals, abstract books and conference proceedings. Most recent search of the Group's Cystic Fibrosis Trials Register: 30 May 2019.
We also searched online trials registries. Most recent search of the ClinicalTrials.gov and WHO International Clinical Trials Registry Platform (ICTRP) portal: 06 January 2019.
Selection criteria
Randomised and quasi‐randomised controlled trials comparing different durations of intravenous antibiotic courses for acute respiratory exacerbations in people with CF, either with the same drugs at the same dosage, the same drugs at a different dosage or frequency or different antibiotics altogether, including studies with additional therapeutic agents.
Data collection and analysis
No eligible trials were identified for inclusion. A trial looking at the standardised treatment of pulmonary exacerbations is currently ongoing and will be included when the results are published.
Main results
No eligible trials were included.
Authors' conclusions
There are no clear guidelines on the optimum duration of intravenous antibiotic treatment. Duration of treatment is currently based on unit policies and response to treatment. Shorter duration of treatment should improve quality of life and adherence, result in a reduced incidence of drug reactions and be less costly. However, the shorter duration may not be sufficient to clear a chest infection and may result in an early recurrence of an exacerbation. This systematic review identifies the need for a multicentre, randomised controlled trial comparing different durations of intravenous antibiotic treatment as it has important clinical and financial implications. The currently ongoing STOP2 trial is expected to provide some guidance on these questions when published
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