36,120 research outputs found

    Elastic and plastic analysis of pressure vessel weld lands with mismatch

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    Elastic and plastic analysis of pressure vessel weld lands with mismatc

    Elastic and plastic stresses at weld sinkages and other discontinuities in pressure vessels

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    Mismatch and weld sinkage problems of pressure vessel geometric discontinuities studied in design graphs and test progra

    Non-Universal Gaugino Masses, CDMS, and the LHC

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    We consider the possibility that the recently reported events at the CDMS-II direct dark matter detection experiment are the result of coherent scattering of supersymmetric neutralinos. In such a scenario we argue that non-universal soft supersymmetry breaking gaugino masses are favored with a resulting lightest neutralino with significant Higgsino and wino components. We discuss the accompanying signals which must be seen at liquid-xenon direct detection experiments and indirect detection experiments if such a supersymmetric interpretation is to be maintained. We illustrate the possible consequences for early discovery channels at the LHC via a set of benchmark points designed to give rise to an observed event rate comparable to the reported CDMS-II data.Comment: Typos corrected and references adde

    Conjugative transfer frequencies of mef(A)-containing Tn1207.3 to macrolide-susceptible Streptococcus pyogenes belonging to different emm types

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    The aim of this study was to examine the gene transfer potential of mef(A)-containing Tn120.3 to macrolide-susceptible Streptococcus pyogenes belonging to different emm types. Using the filter mating technique, Tn1207.3 was transferred by conjugation to 23 macrolide-susceptible recipients representing 11 emm types. PCR analysis confirmed the presence of the mef(A) gene and the comEC junction regions of the Tn1207.3 insertion in resultant transconjugants. Significant variation was found in the transfer frequency of Tn1207.3 to different Strep. pyogenes strains, and this phenomenon may contribute to the differences in mef(A) frequency observed among clinical isolates. Significance and Impact of the Study: The spread of antimicrobial resistance among pathogenic bacteria is an important problem, but the mechanisms of horizontal transfer between strains and species are often poorly understood. For instance, little is known on how macrolide resistance spreads between strains of the human pathogen Strep. pyogenes and why certain strains more commonly display resistance than others. Here, we show that Strep. pyogenes strains vary greatly in their ability to acquire a transposon encoding macrolide resistance by horizontal gene transfer in vitro. These data provide a novel insight into the transfer of antibiotic resistance between bacterial strains and offer an explanation for the differences in the frequency of resistance determinates and resistance seen among clinical isolates. © 2014 The Authors Letters in Applied Microbiology
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