Prevalence of oral mucosal lesions in psoriatic patients: a controlled study

Objectives: This study aimed to investigate and compare the prevalence of oral mucosal lesions in a group of psoriatic patients and healthy subjects, and its correlation to multiple clinical parameters. Study design: 100 psoriatic patients and 100 closely matched controls underwent clinical oral examination. Oral lesions were diagnosed according to the criteria proposed by the World Health Organization (WHO). The patients filled the Hospital Anxiety and Depression (HAD) questionnaire and the Dermatology Life Quality Index (DLQI). The severity of psoriasis was assessed by the Psoriasis Area and Severity Index (PASI). Categorical variables were evaluated using Chi-square test or Fisher's exact test with overall significance set at p< 0.05. Results: Oral mucosal lesions were diagnosed in 43 (43%) psoriatic patients and 17 (17%) control subjects (p=0.000). Comparing psoriatic patients to control subjects the prevalence of fissured tongue (FT) was 35% vs. 13% (p=0.000); geographic tongue (GT) 17% vs. 9% (p=0.09); combination of FT and GT 5% vs. 5% (p=1.00); oral candidosis 3% vs. 0% (p=0.81); leukoedema 1% vs. 3% (p=0.62); physiologic melanin pigmentations 4% vs. 1% (p=0.37) respectively. The clinical type of psoriasis, duration of the disease, method of disease management (medicated vs. non-medicated for psoriasis), smoking habit, psychological status or the disease severity did not influence the prevalence of FT and GT. Psoriatic patients who experienced 'very large' to 'extremely large' adverse effect of psoriasis on their quality of life have significantly higher prevalence of GT (p=0.04). Conclusions: FT is significantly more common in psoriatic patients compared to controls; hence studies investigating the nature of this relationship are warranted. Oral health care providers should be aware of the predisposition of psoriatic patients to oral candidosis

Priprava derivata 4-aminofeniloctene kiseline s antimikrobnim djelovanjem

Condensation of 4-APAA with phthalic anhydride gave (dioxoisoindolin-2-yl)phenylacetic acid 1, which is employed as key intermediate in the synthesis of title compounds 2-8. The products have been characterized by analytical and spectral data (IR, 1H NMR, 13C NMR and mass spectra). Antimicrobial activities were also studied and some of these compounds gave promising results.Kondenzacijom 4-APAA s anhidridom ftalne kiseline dobivena je (dioksoizoindolin-2-il)feniloctena kiselina 1, koja je upotrebljena kao ključni intermedijer u sintezi spojeva 2-8. Produkti su karakterizirani analitičkim i spektroskopskim metodama (IR, 1H NMR, 13C NMR i MS). Neki od sintetiziranih spojeva ima značajno antimikrobno djelovanje

MATHEMATICAL MODEL TO PREDICT THE DISTRIBUTION OF SOIL MOISTURE IN THE ROOT ZONE OF TURF LANDSCAPE

Field experiment was carried out on one of the turf (lawn) , category  (Passpalm 10) to study the effect of irrigation systems on soil moisture distribution in the root zone. Experimental plot area was (4.5*4.5  ), soil media used was sandy soil and three treatments (spray, sub surface drib irrigation (SDI) , hydrogel) irrigation and every treatment replicated three times . Results of this research could be summarized as follows: Annual water consumption was less by 77.3%, 71.3% when using hydrogel material, compared with other irrigation systems (spray, and SDI) resp. , this is due to the quantity of loss water from evaporation in spray irrigation treatment , where evaporation parameters are more effective than the others (SDI, hydrogel) irrigation treatments.  The hydrogel treatment has highest water saving by 170% ,300% compared with (SDI and spray) irrigation treatments , because the hydrogel's ability to hold water and has a large period between irrigation when using hydrogel in the soil .  The SDI treatment has highest electrical saving by 520% ,55% compared with (spray and hydrogel ) irrigation treatments resp.  The turf quality index (color, density, ground cover ) give high degree at hydrogel treatment compared with others, this is due to the hydrogel has many materials , both nat urally occurring and synthetic and ability of water saving around root zone of turf . The average of soil moisture contents at (10cm and 15cm) depth of soil under hydrogel treatment was highest compared with (Spray and SDI) irrigation systems  resp

Validated Spectrophotometric Methods for the Determination of Nabumetone in Tablets Dosage Form Using Three Dinitrobenzene Reagents

ABSTRACT Three spectrophotometric methods have been described for the determination of nabumetone (NAB) in its tablets dosage form. The methods are based on the reaction of nabumetone with three dinitrobenzene reagents, namely, m-dinitrobenzene (DNB), 1-chloro-2,4-dinitrobenzene (CDNB) and 1-fluoro-2,4-dinitrobenzene (FDNB) in alkaline medium (alcoholic potassium hydroxide solution). The studied reactions depend on the tendency of these dinitrobenzene reagents to react with the active methylene adjacent to the carbonyl group of the drug. Illustrative proposed pathways showing the reaction of NAB with the three dinitrobenzene reagents were presented. Spectrophotometric measurements were achieved by recording the absorbances at 580, 573 and 574 nm for the reaction with DNB, CDNB and FDNB respectively. Different experimental parameters affecting development and stability of the produced colors were optimized. The three methods were validated with respect to linearity, ranges, precision, accuracy and limits of detection and quantification. Beer&apos;s law was obeyed in the concentration ranges of 2-10, 40-240 and 10-50 µg/mL for DNB, CDNB and FDNB methods respectively with correlation coefficient values not less than 0.9994. In addition, detection limits of NAB were 0.27, 8.54 and 2.04 µg/mL for DNB, CDNB and FDNB methods, respectively. The proposed methods were successfully applied for assay of the drug in its tablets dosage form. Recovery data obtained by the proposed methods were favorably compared with those obtained by a reported spectrophotometric method

Performance analysis of AlGaAs/GaAs tunnel junctions for ultra-high concentration photovoltaics

An n(++)-GaAs/p(++)-AlGaAs tunnel junction with a peak current density of 10 100Acm(-2) is developed. This device is a tunnel junction for multijunction solar cells, grown lattice-matched on standard GaAs or Ge substrates, with the highest peak current density ever reported. The voltage drop for a current density equivalent to the operation of the multijunction solar cell up to 10 000 suns is below 5 mV. Trap-assisted tunnelling is proposed to be behind this performance, which cannot be justified by simple band-to-band tunnelling. The metal-organic vapour-phase epitaxy growth conditions, which are in the limits of the transport-limited regime, and the heavy tellurium doping levels are the proposed origins of the defects enabling trap-assisted tunnelling. The hypothesis of trap-assisted tunnelling is supported by the observed annealing behaviour of the tunnel junctions, which cannot be explained in terms of dopant diffusion or passivation. For the integration of these tunnel junctions into a triple-junction solar cell, AlGaAs barrier layers are introduced to suppress the formation of parasitic junctions, but this is found to significantly degrade the performance of the tunnel junctions. However, the annealed tunnel junctions with barrier layers still exhibit a peak current density higher than 2500Acm(-2) and a voltage drop at 10 000 suns of around 20 mV, which are excellent properties for tunnel junctions and mean they can serve as low-loss interconnections in multijunction solar cells working at ultra-high concentrations

Synthesis and Reactions of Some New Diiodocoumarin Derivatives Bearing Side Chains and Some of Their Biological Activities

Abstract The synthesis of 6,8-diiodocoumarin derivatives (2-6) by condensation of 3,5-diiodosalicylaldehyde (1) with active methylene compounds is described. Reaction of 6 with malononitrile afforded two products pyridine and ethylidine malononitrile derivative

Fine structure of near-band-edge photoluminescence in He+-irradiated GaN grown on SiC

The effect of He ion implantation on the optical properties of epitaxial GaN-on-SiC was studied. We observed that He + irradiation increases the relative intensity of the “blue emission” and resistivity of GaN films and decreases the intensity of the near-band-edge photoluminescence. Because the intensity of the main peak is drastically decreased, the fine structure of the near-band-edge photoluminescence in GaN after He + irradiation was observed. From a comparison of observed sharp lines with photoluminescence peaks of GaNdoped with oxygen, we conclude that oxygen can produce a complex, which is characterized by a strong localization of free carriers and a large lattice distortion. The zero-phonon line of this defect has energy close to the band-gap energy of GaN

Low‐temperature growth of high resistivity GaAs by photoassisted metalorganic chemical vapor deposition

We report the photoassisted low‐temperature (LT) metalorganic chemical vapor deposition (MOCVD) of high resistivity GaAs. The undoped as‐grown GaAs exhibits a resistivity of ∼106 Ω cm, which is the highest reported for undoped material grown in the MOCVD environment. Photoassisted growth of doped and undoped device quality GaAs has been achieved at a substrate temperature of 400 °C in a modified atmospheric pressure MOCVD reactor. By using silane as a dopant gas, the LT photoassisted doped films have high levels of doping and electron mobilities comparable to those achieved by MOCVD for growth temperatures, Tg≳600 °C

Regeneration of Soft Tissues Is Promoted by MMP1 Treatment after Digit Amputation in Mice

The ratio of matrix metalloproteinases (MMPs) to the tissue inhibitors of metalloproteinases (TIMPs) in wounded tissues strictly control the protease activity of MMPs, and therefore regulate the progress of wound closure, tissue regeneration and scar formation. Some amphibians (i.e. axolotl/newt) demonstrate complete regeneration of missing or wounded digits and even limbs; MMPs play a critical role during amphibian regeneration. Conversely, mammalian wound healing re-establishes tissue integrity, but at the expense of scar tissue formation. The differences between amphibian regeneration and mammalian wound healing can be attributed to the greater ratio of MMPs to TIMPs in amphibian tissue. Previous studies have demonstrated the ability of MMP1 to effectively promote skeletal muscle regeneration by favoring extracellular matrix (ECM) remodeling to enhance cell proliferation and migration. In this study, MMP1 was administered to the digits amputated at the mid-second phalanx of adult mice to observe its effect on digit regeneration. Results indicated that the regeneration of soft tissue and the rate of wound closure were significantly improved by MMP1 administration, but the elongation of the skeletal tissue was insignificantly affected. During digit regeneration, more mutipotent progenitor cells, capillary vasculature and neuromuscular-related tissues were observed in MMP1 treated tissues; moreover, there was less fibrotic tissue formed in treated digits. In summary, MMP1 was found to be effective in promoting wound healing in amputated digits of adult mice. © 2013 Mu et al