533 research outputs found
Multiple abnormalities in the skull of a prostitute. An autopsy report (1900)
OBJECTIVE: The study presents and comments on the publication of an autopsy report. CASE REPORT: In 1900 De Blasio published an article entitled "Multiple abnormalities in a prostitute's skull" in the "Journal of Psychiatry, Criminal Anthropology and related sciences". In this work De Blasio related anomalies at the cranial level to the presence of mental pathologies. The skull belonged to a 24-year-old prostitute who died of syphilitic hepatitis. In his article, De Blasio described the life of the woman, after which he gave a macroscopic description of the skull. De Blasio believed that the subject's amoral behavior was caused by the anomalous shape of the subject's skull. CONCLUSION: From the study, it is evident that the school of criminal anthropology influenced De Blasio's autopsy medical practice, and it is interesting to note the interpretation of anthropologists of the time who tried to describe the link between physical and behavioral anomalies
Reconstructing the Density of States by History-Dependent Metadynamics
We present a novel method for the calculation of the energy density of states
D(E) for systems described by classical statistical mechanics. The method
builds on an extension of a recently proposed strategy that allows the free
energy profile of a canonical system to be recovered within a pre-assigned
accuracy,[A. Laio and M. Parrinello, PNAS 2002]. The method allows a good
control over the error on the recovered system entropy. This fact is exploited
to obtain D(E) more efficiently by combining measurements at different
temperatures. The accuracy and efficiency of the method are tested for the
two-dimensional Ising model (up to size 50x50) by comparison with both exact
results and previous studies. This method is a general one and should be
applicable to more realistic model systems
Time resolved depression of isometric force by Mavacamten in single myofibrils from rabbit psoas and human cardiac muscle
RNA denaturation: excluded volume, pseudoknots and transition scenarios
A lattice model of RNA denaturation which fully accounts for the excluded
volume effects among nucleotides is proposed. A numerical study shows that
interactions forming pseudoknots must be included in order to get a sharp
continuous transition. Otherwise a smooth crossover occurs from the swollen
linear polymer behavior to highly ramified, almost compact conformations with
secondary structures. In the latter scenario, which is appropriate when these
structures are much more stable than pseudoknot links, probability
distributions for the lengths of both loops and main branches obey scaling with
nonclassical exponents.Comment: 4 pages 3 figure
The relation between sarcomere energetics and the rate of isometric tension relaxation in healthy and diseased cardiac muscle
Mavacamten has a differential impact on force generation in myofibrils from rabbit psoas and human cardiac muscle
Roles of stiffness and excluded volume in DNA denaturation
The nature and the universal properties of DNA thermal denaturation are
investigated by Monte Carlo simulations. For suitable lattice models we
determine the exponent c describing the decay of the probability distribution
of denaturated loops of length l, . If excluded volume effects
are fully taken into account, c= 2.10(4) is consistent with a first order
transition. The stiffness of the double stranded chain has the effect of
sharpening the transition, if it is continuous, but not of changing its order
and the value of the exponent c, which is also robust with respect to inclusion
of specific base-pair sequence heterogeneities.Comment: RevTeX 4 Pages and 4 PostScript figures included. Final version as
publishe
Specific immunotherapy for allergic rhinitis in Italy: The patients' points of view
Specific immunotherapy (SIT) is the unique causal treatment for allergy, but its use is quite limited. A perspective, cross-sectional telephone interview survey was carried out in Italy to evaluate the characteristics of 500 patients with allergic rhinitis (250 of whom treated with SIT). Relevant differences were found concerning therapeutic management of allergic rhinitis, mainly regarding the use of drugs and co-morbidities. The allergist is the most important consultant who prescribes SIT. This study therefore provides evidence that the course of allergic rhinitis may depend on the therapy prescribed by and the level of allergy awareness of the physician
On the size of knots in ring polymers
We give two different, statistically consistent definitions of the length l
of a prime knot tied into a polymer ring. In the good solvent regime the
polymer is modelled by a self avoiding polygon of N steps on cubic lattice and
l is the number of steps over which the knot ``spreads'' in a given
configuration. An analysis of extensive Monte Carlo data in equilibrium shows
that the probability distribution of l as a function of N obeys a scaling of
the form p(l,N) ~ l^(-c) f(l/N^D), with c ~ 1.25 and D ~ 1. Both D and c could
be independent of knot type. As a consequence, the knot is weakly localized,
i.e. ~ N^t, with t=2-c ~ 0.75. For a ring with fixed knot type, weak
localization implies the existence of a peculiar characteristic length l^(nu) ~
N^(t nu). In the scaling ~ N^(nu) (nu ~0.58) of the radius of gyration of the
whole ring, this length determines a leading power law correction which is much
stronger than that found in the case of unrestricted topology. The existence of
such correction is confirmed by an analysis of extensive Monte Carlo data for
the radius of gyration. The collapsed regime is studied by introducing in the
model sufficiently strong attractive interactions for nearest neighbor sites
visited by the self-avoiding polygon. In this regime knot length determinations
can be based on the entropic competition between two knotted loops separated by
a slip link. These measurements enable us to conclude that each knot is
delocalized (t ~ 1).Comment: 29 pages, 14 figure
Bending-rigidity-driven transition and crumpling-point scaling of lattice vesicles
The crumpling transition of three-dimensional (3D) lattice vesicles subject to a bending fugacity \ensuremath{\rho}=exp(-\ensuremath{\kappa}/) is investigated by Monte Carlo methods in a grand canonical framework. By also exploiting conjectures suggested by previous rigorous results, a critical regime with scaling behavior in the universality class of branched polymers is found to exist for \ensuremath{\rho}\ensuremath{\gtrsim}{\mathrm{\ensuremath{\rho}}}_{\mathit{c}}. For \ensuremath{\rho}{\mathrm{\ensuremath{\rho}}}_{\mathit{c}} the vesicles undergo a first-order transition that has remarkable similarities to the line of droplet singularities of inflated 2D vesicles. At the crumpling point (\ensuremath{\rho}={\mathrm{\ensuremath{\rho}}}_{\mathit{c}}), which has a tricritical character, the average radius and the canonical partition function of vesicles with n plaquettes scale as {\mathit{n}}^{{\ensuremath{\nu}}_{\mathit{c}}} and {\mathit{n}}^{\mathrm{\ensuremath{-}}{\mathrm{\ensuremath{\theta}}}_{\mathit{c}}}, respectively, with {\ensuremath{\nu}}_{\mathit{c}}=0.4825\ifmmode\pm\else\textpm\fi{}0.0015 and {\mathrm{\ensuremath{\theta}}}_{\mathit{c}}=1.78\ifmmode\pm\else\textpm\fi{}0.03. These exponents indicate a new class, distinct from that of branched polymers, for scaling at the crumpling point. \textcopyright{} 1996 The American Physical Society
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