6,533 research outputs found
Plasticity in current-driven vortex lattices
We present a theoretical analysis of recent experiments on current-driven
vortex dynamics in the Corbino disk geometry. This geometry introduces
controlled spatial gradients in the driving force and allows the study of the
onset of plasticity and tearing in clean vortex lattices. We describe plastic
slip in terms of the stress-driven unbinding of dislocation pairs, which in
turn contribute to the relaxation of the shear, yielding a nonlinear response.
The steady state density of free dislocations induced by the applied stress is
calculated as a function of the applied current and temperature. A criterion
for the onset of plasticity at a radial location in the disk yields a
temperature-dependent critical current that is in qualitative agreement with
experiments.Comment: 11 pages, 4 figure
Peak effect in twinned superconductors
A sharp maximum in the critical current as a function of temperature
just below the melting point of the Abrikosov flux lattice has recently been
observed in both low and high temperature superconductors. This peak effect is
strongest in twinned crystals for fields aligned with the twin planes. We
propose that this peak signals the breakdown of the collective pinning regime
and the crossover to strong pinning of single vortices on the twin boundaries.
This crossover is very sharp and can account for the steep drop of the
differential resistivity observed in experiments.Comment: 4 pages, revtex 3.0, no figure
Spontaneous patterns in coherently driven polariton microcavities
We consider a polariton microcavity resonantly driven by two external lasers
which simultaneously pump both lower and upper polariton branches at normal
incidence. In this setup, we study the occurrence of instabilities of the
pump-only solutions towards the spontaneous formation of patterns. Their
appearance is a consequence of the spontaneous symmetry breaking of
translational and rotational invariance due to interaction induced parametric
scattering. We observe the evolution between diverse patterns which can be
classified as single-pump, where parametric scattering occurs at the same
energy as one of the pumps, and as two-pump, where scattering occurs at a
different energy. For two-pump instabilities, stripe and chequerboard patterns
become the dominant steady-state solutions because cubic parametric scattering
processes are forbidden. This contrasts with the single-pump case, where
hexagonal patterns are the most common arrangements. We study the possibility
of controlling the evolution between different patterns. Our results are
obtained within a linear stability analysis and are confirmed by finite size
full numerical calculations.Comment: 15 pages, 9 figure
Models of plastic depinning of driven disordered systems
Two classes of models of driven disordered systems that exhibit
history-dependent dynamics are discussed. The first class incorporates local
inertia in the dynamics via nonmonotonic stress transfer between adjacent
degrees of freedom. The second class allows for proliferation of topological
defects due to the interplay of strong disorder and drive. In mean field theory
both models exhibit a tricritical point as a function of disorder strength. At
weak disorder depinning is continuous and the sliding state is unique. At
strong disorder depinning is discontinuous and hysteretic.Comment: 3 figures, invited talk at StatPhys 2
Driven depinning of strongly disordered media and anisotropic mean-field limits
Extended systems driven through strong disorder are modeled generically using
coarse-grained degrees of freedom that interact elastically in the directions
parallel to the driving force and that slip along at least one of the
directions transverse to the motion. A realization of such a model is a
collection of elastic channels with transverse viscous couplings. In the
infinite range limit this model has a tricritical point separating a region
where the depinning is continuous, in the universality class of elastic
depinning, from a region where depinning is hysteretic. Many of the collective
transport models discussed in the literature are special cases of the generic
model.Comment: 4 pages, 2 figure
Predictive biomarkers for checkpoint inhibitor-based immunotherapy: The Galectin-3 signature in NSCLCs
Checkpoint inhibitor-based immunotherapy is opening a promising scenario in oncology, with objective responses registered in multiple cancer types. However, reliable predictive markers of tumor responsiveness are still lacking. These markers need to be urgently identified for a better selection of patients that can be candidates for immunotherapy. In this pilot study, a cohort of 34 consecutive patients bearing programmed death-ligand 1 (PD-L1)-positive non-small cell lung carcinoma (NSCLC), treated with pembrolizumab, was considered. The retrospective immuno-phenotypic analysis performed on the original tumor biopsies allowed for the identification of a specific “galectin signature”, which strongly correlated with tumor responsiveness to anti PD-1 immunotherapy. We observed that the large majority of patients (about 90%) with high galectin-3 tumor expression (score 3+) showed an early and dramatic progression of the disease after three cycles of treatments. In contrast, all patients with negative or low/intermediate expression of galectin-3 in tumor cells showed an early and durable objective response to pembrolizumab, indicating galectin-3 as an interesting predictive marker of tumor responsiveness. The galectin-3 signature, at least in NSCLCs, promises a better selection of patient candidates for immunotherapy, reducing unnecessary treatment exposures and social costs. A large multicenter study is ongoing to validate this finding
Translational Correlations in the Vortex Array at the Surface of a Type-II Superconductor
We discuss the statistical mechanics of magnetic flux lines in a
finite-thickness slab of type-II superconductor. The long wavelength properties
of a flux-line liquid in a slab geometry are described by a hydrodynamic free
energy that incorporates the boundary conditions on the flux lines at the
sample's surface as a surface contribution to the free energy. Bulk and surface
weak disorder are modeled via Gaussian impurity potentials. This free energy is
used to evaluate the two-dimensional structure factor of the flux-line tips at
the sample surface. We find that surface interaction always dominates in
determining the decay of translational correlations in the asymptotic
long-wavelength limit. On the other hand, such large length scales have not
been probed by the decoration experiments. Our results indicate that the
translational correlations extracted from the analysis of the Bitter patterns
are indeed representative of behavior of flux lines in the bulk.Comment: 23 pages, 1 figure (not included), harvmac.tex macro needed (e-mail
requests to [email protected] SU-CM-92-01
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