Konsultasi Pemilihan Audio Mobil Menggunakan Metoda Forward Chaining

Audio is one of the tool for listening music that certainly will you found in car with the purpose to dispose boring time while driving. Character of car audio sound consists of sound quality, sound quality loud and sound pressure loud. Car users do not necessarily know about the audio devices that are used but have the desire to change it for the better. There are several kinds of audio devices and goods provided manifold. It takes a long time to understand the device from the car audio. Therefore, the application of expert systems can help users car in giving advice to use audio package as you wish. This application uses forward chaining method and desktop-based. The data used came from car audio specialist. This application uses the media image and the information provided to be more understandable. The application will give suggestions about audio package that can be used

Geometric Isomers and Cytotoxic Effect On T47D Cells of Curcumin Analogues PGV-0 and PGV-1

Curcumin analogues 2,5-bis-(4’-hidroxy-3’-methoxy)-benzilidinecylopentanone (PGV-0) and 2,5-bis-(4’hidroxy-3’,5’-dimethyl)-benzilidinecylopentanone (PGV-1) have a potency to be developed as cytotoxic agent. The aims of this research are to elucidate the geometric isomer and to study the cytotoxic effect on T47D cells of both compounds. To establish the geometric isomer these compounds, they were elucidated by LC-MS, 1H-NMR, 13C-NMR, HMBC, HMQC, NOESY. Their cytotoxic effect were evaluated by MTT assay method on T47D cells. The results concluded that the geometric isomer of PGV-1 is zusammen-zusammen (Z-Z) and PGV-0 is entgegen-entgegen (EE). The IC50 of both compounds are 1.74 and 9.39 μM respectively.Key words: PGV-0, PGV-1, Cytotoxicit

EFEK ANTIPROLIFERATIF PENTAGAMAVUNON O TERHADAP BEBERAPA SEL KANKER

Senyawa 1,5 difenil 1,4 pentadiena 3 on yaitu 2,5 bis (4 hidroksi 3¬metoksi-benzilidin) siklopentanon (PGV 0) yang merupakan analog kurkumin (1,7 bis(4-hidroksi-¬3 metoksifenil) 1,6 heptadiena 3,5 dion) telah berhasil disintesis dan diuji aktivitas sitotoksik dan sifat penghambatan terhadap penggandaan sel kanker. Uji akfivitas sitotoksik PGV 0 terhadap sel Hela memberikan nilai LC50 2,85 &#6154