Use of weaning concentrate in the feeding suckling kids: effects on meat quality

The effect of a feeding supplementation with starter concentrate on “Capretto” meat production and its qualitative characteristics was investigated. The results showed that the effect of concentrate supplementation did not influence the slaughter weight, slaughter and dissection data, tissue composition and meat chemical composition of the pelvic limb. No differences were found for rheological characteristics of LD meat, except cohesiveness values, which were higher in the concentrate group kids

Health Educ Behav

UL1 TR000433/TR/NCATS NIH HHS/United States5U01CE001957-02/CE/NCIPC CDC HHS/United StatesDA07484/DA/NIDA NIH HHS/United StatesUL1TR000433/TR/NCATS NIH HHS/United StatesR01 DA007484/DA/NIDA NIH HHS/United StatesU01 CE001957/CE/NCIPC CDC HHS/United States2014-03-26T00:00:00Z23863911PMC396656

Extracellular matrix alterations in metastatic processes

The extracellular matrix (ECM) is a complex network of extracellular-secreted macromolecules, such as collagen, enzymes and glycoproteins, whose main functions deal with structural scaffolding and biochemical support of cells and tissues. ECM homeostasis is essential for organ development and functioning under physiological conditions, while its sustained modification or dysregulation can result in pathological conditions. During cancer progression, epithelial tumor cells may undergo epithelial-to-mesenchymal transition (EMT), a morphological and functional remodeling, that deeply alters tumor cell features, leading to loss of epithelial markers (i.e., E-cadherin), changes in cell polarity and intercellular junctions and increase of mesenchymal markers (i.e., N-cadherin, fibronectin and vimentin). This process enhances cancer cell detachment from the original tumor mass and invasiveness, which are necessary for metastasis onset, thus allowing cancer cells to enter the bloodstream or lymphatic flow and colonize distant sites. The mechanisms that lead to development of metastases in specific sites are still largely obscure but modifications occurring in target tissue ECM are being intensively studied. Matrix metalloproteases and several adhesion receptors, among which integrins play a key role, are involved in metastasis-linked ECM modifications. In addition, cells involved in the metastatic niche formation, like cancer associated fibroblasts (CAF) and tumor associated macrophages (TAM), have been found to play crucial roles in ECM alterations aimed at promoting cancer cells adhesion and growth. In this review we focus on molecular mechanisms of ECM modifications occurring during cancer progression and metastatic dissemination to distant sites, with special attention to lung, liver and bone. Moreover, the functional role of cells forming the tumor niche will also be reviewed in light of the most recent findings

In vitro glioblastoma models: A journey into the third dimension

Glioblastoma multiforme (GBM) is the most lethal primary brain tumor in adults, with an average survival time of about one year from initial diagnosis. In the attempt to overcome the com-plexity and drawbacks associated with in vivo GBM models, together with the need of developing systems dedicated to screen new potential drugs, considerable efforts have been devoted to the implementation of reliable and affordable in vitro GBM models. Recent findings on GBM molecular features, revealing a high heterogeneity between GBM cells and also between other non‐tumor cells belonging to the tumoral niche, have stressed the limitations of the classical 2D cell culture systems. Recently, several novel and innovative 3D cell cultures models for GBM have been proposed and implemented. In this review, we first describe the different populations and their functional role of GBM and niche non‐tumor cells that could be used in 3D models. An overview of the current available 3D in vitro systems for modeling GBM, together with their major weaknesses and strengths, is presented. Lastly, we discuss the impact of groundbreaking technologies, such as bioprinting and multi‐omics single cell analysis, on the future implementation of 3D in vitro GBM models

VALUTAZIONE CLINICA E TERAPEUTICA DELLA ROTTURA PREMATURA DELLE MEMBRANE PRIMA DELLA 28^ SETTIMANA GESTAZIONALE. OUTCOME NEONATALE

Abbiamo preso in considerazione 25 gravide con rottura prematura delle membrane fra la 15.ma e la 28.ma settimana gestazionale. E' stato condotto sul campione in esame un accurato monitoraggio materno fetale insieme ad una terapia antibiotica, tocolitica e induzione della maturita' polmonare. 12 dei 25 casi da noi selezionati hanno avuto un esito neonatale favorevole e sono attualmente seguiti dal Centro di Patologia Neonatale dell'Universita' di Padova. Questo risultato confortante giustifica la nostra condotta terapeutica sempre nell'interno di migliorare l'outcome neonatale

Reconsidering the Existing Paradigm for Suicide Prevention among Older Adult Veterans and Other Americans

A review of findings from research on risk for suicide among older adult veterans by Sullivan and colleagues identified several factors, including diagnosis with posttraumatic stress disorder and social isolation associated with increased risk for self-harm among older adult veterans. While this review will surely raise awareness of characteristics associated with suicide among older Veterans, the assumptions underlying much of the reviewed literature limit utility of these findings. In the following sections we provide a critical review of existing research, identify gaps in previous efforts and suggest ways for research and clinical services to improve on existing services