Interventional Radiology Approaches for Liver Metastases from Thyroid Cancer: A Case Series and Overview of the Literature

BACKGROUND: Liver metastases (LMs) from thyroid cancer (TC) are relatively uncommon in clinical practice and their management is challenging. Interventional radiology loco-regional treatments (LRTs), including radiofrequency ablation (RFA) and trans-arterial chemoembolization (TACE), have been successfully employed to treat LMs from various types of cancer. METHODS: We analyzed the role of LRTs in the management of unresectable LMs from differentiated and medullary TCs performed at our institution from 2015 to 2020. A review of the available English literature regarding this topic was also performed. RESULTS: Six hepatic LRTs were performed in 4 TC patients with LMs, in 2 cases after the start of treatment with a tyrosine kinase inhibitor (TKI). A partial response was obtained in 2 patients; the diameter of the largest targeted lesion was 18 mm in both of them. The remaining procedures were performed on larger lesions and a stable disease was achieved in all but one case. Acute LRT-related complications were transient and mild. In literature, the largest studies were focused on TACE in LMs from MTC, showing good tolerance and remarkable disease control, especially in case of limited liver tumour involvement. CONCLUSION: LRTs for LMs represent a valuable option for the treatment of metastatic TC in case of isolated hepatic progression or for symptoms relief, also after the start of TKI treatment as part of a multimodal approach. The best disease control is obtained when hepatic metastatic burden is limited. These procedures are generally well tolerated; however, a cautious multidisciplinary selection of the candidates is mandatory

Educción de dinámica de tecleo centrado en el contexto emocional de un individuo

El proyecto se orienta al desarrollo de un Framework que permita determinar las relaciones entre el estado emocional de un individuo, adquirido a través una interfaz cerebro—computadora (BMI), con su dinámica de tecleo. La investigación se enfoca en definir un entorno de trabajo donde se puedan analizar modelos posibles del estado emocional adquirido, descubrir los cambios temporales en la cadencia de tecleo que de ellos resultan y analizarlos buscando predictibilidad y patrones de adaptación a mediano plazo. En el último año exploramos la forma en que los usuarios varían su dinámica de tecleo a lo largo del tiempo. Utilizando el principio de variación paralela, hay una forma de “olvidar” lo aprendido e ir reemplazándolo por datos actualizados. También estamos explorando nuevos campos en la dinámica de tecleo, que incluyen la detección del estado emocional del usuario y el modelado de textos libres utilizando contextos finitos en forma similar a los esquemas de compresión de datos con predicción por coincidencia parcial.Eje: Seguridad InformáticaRed de Universidades con Carreras en Informática (RedUNCI

Educción de dinámica de tecleo centrado en el contexto emocional de un individuo

El proyecto se orienta al desarrollo de un Framework que permita determinar las relaciones entre el estado emocional de un individuo, adquirido a través una interfaz cerebro-computadora (BMI), con su dinámica de tecleo. La investigación se enfoca en definir un entorno de trabajo donde se puedan analizar modelos posibles del estado emocional adquirido, descubrir los cambios temporales en la cadencia de tecleo que de ellos resultan y analizarlos buscando predictibilidad y patrones de adaptación a mediano plazo. En el último año exploramos la forma en que los usuarios varían su dinámica de tecleo a lo largo del tiempo. Utilizando el principio de variación paralela, hay una forma de “olvidar” lo aprendido e ir reemplazándolo por datos actualizados. También estamos explorando nuevos campos en la dinámica de tecleo, que incluyen la detección del estado emocional del usuario y el modelado de textos libres utilizando contextos finitos en forma similar a los esquemas de compresión de datos con predicción por coincidencia parcial.Eje: Seguridad InformáticaRed de Universidades con Carreras en Informátic

Designing intervention prototypes to improve infant and young child nutrition in Peru: A participatory design study protocol

Introduction: Nutrition during the complementary feeding period (6–23 months) is critical to ensure optimal growth and reduce the risk of diet-related disease across the life course. Strategies to reduce multiple forms of malnutrition (stunting, overweight/obesity and anaemia) in infants and young children (IYC) are a key priority in low-income and middle-income countries, including Peru. This study aims to co-design and develop prototypes for interventions to address the multiple forms of malnutrition in IYC in urban Peru, using a participatory design approach. Methods and analysis: The study will be based within peri-urban communities in two areas of Peru (Lima and Huánuco city). Following the identification of key nutritional challenges for IYC aged 6–23 months through formative research (phase I), we will conduct a series of workshops bringing together healthcare professionals from government health centres and caregivers of IYC aged 6–23 months. Workshops (on idea generation; creating future scenarios; storyboarding and early implementation and feedback) will take place in parallel in the two study areas. Through these workshops, we will engage with community participants to explore, experiment, co-design and iteratively validate new design ideas to address the challenges around IYC complementary feeding from phase I. Workshop outputs and transcripts will be analysed qualitatively using affinity diagramming and thematic analyses. The intervention prototypes will be evaluated qualitatively and piloted with the participating communities. Ethics and dissemination: Ethical approval for this study was obtained from the Ethical Review Committee of the Instituto de Investigación Nutricional (IIN) Peru (388-2019/CIEI-IIN), Loughborough University (C19-87) and confirmed by Cardiff University. Findings of the participatory design process will be disseminated through a deliberative workshop in Lima, Peru with national and regional government stakeholders, as well as participants and researchers involved in the design process. Further dissemination will take place through policy briefs, conferences and academic publications