Rapid Reservoir Sedimentation of Four Historic Thin Arch Dams in Australia

Waters flowing in streams and rivers have the ability to scour channel beds, to carry particles (heavier than water) and to deposit materials. This phenomenon of sediment transport can affect substantially the design of reservoirs. The paper describes four case studies of siltation which rendered useless water storage structures in less than 25 years. Although each dam had advanced structural features, the hydrology of the catchment and sediment transport processes were not properly taken into account. The study highlights practical situations in which a reservoir must be analysed as a complete system, taking into account structural features, hydraulics, hydrology, sediment transport, catchment erosion and catchment management. The case studies may used as teaching examples to increase student interest on the significance of sediment transport problems and to emphasise the design procedure to professionals. They may serve also to alert the community at large to basic errors caused by improper soil conservation policy and the inability to predict sediment-load process

Statistical analysis on testing of an entangled state based on Poisson distribution framework

A hypothesis testing scheme for entanglement has been formulated based on the Poisson distribution framework instead of the POVM framework. Three designs were proposed to test the entangled states in this framework. The designs were evaluated in terms of the asymptotic variance. It has been shown that the optimal time allocation between the coincidence and anti-coincidence measurement bases improves the conventional testing method. The test can be further improved by optimizing the time allocation between the anti-coincidence bases.Comment: This paper is an extended version of the theoretical part of v1 of quant-ph/0603254.quant-ph/0603254 is revised so that it is more familiar to experimentalist

Traumatic brain injury leads to alterations in contusional cortical miRNAs involved in dementia

There is compelling evidence that head injury is a significant environmental risk factor for Alzheimer's disease (AD) and that a history of traumatic brain injury (TBI) accelerates the onset of AD. Amyloid-β plaques and tau aggregates have been observed in the post-mortem brains of TBI patients; however, the mechanisms leading to AD neuropathology in TBI are still unknown. In this study, we hypothesized that focal TBI induces changes in miRNA expression in and around affected areas, resulting in the altered expression of genes involved in neurodegeneration and AD pathology. For this purpose, we performed a miRNA array in extracts from rats subjected to experimental TBI, using the controlled cortical impact (CCI) model. In and around the contusion, we observed alterations of miRNAs associated with dementia/AD, compared to the contralateral side. Specifically, the expression of miR-9 was significantly upregulated, while miR-29b, miR-34a, miR-106b, miR-181a and miR-107 were downregulated. Via qPCR, we confirmed these results in an additional group of injured rats when compared to naïve animals. Interestingly, the changes in those miRNAs were concomitant with alterations in the gene expression of mRNAs involved in amyloid generation and tau pathology, such as β-APP cleaving enzyme (BACE1) and Glycogen synthase-3-β (GSK3β). In addition increased levels of neuroinflammatory markers (TNF-α), glial activation, neuronal loss, and tau phosphorylation were observed in pericontusional areas. Therefore, our results suggest that the secondary injury cascade in TBI affects miRNAs regulating the expression of genes involved in AD dementia

Forecasting the extreme rainfall, low temperatures, and strong winds associated with the northern Queensland floods of February 2019

From late January to early February 2019, a quasi-stationary monsoon depression situated over northeast Australia caused devastating floods, killing an estimated 625,000 head of cattle in northwest Queensland, and inundating over 3 000 homes in the coastal city of Townsville. The monsoon depression lasted ~10 days, driving daily rainfall accumulations exceeding 200 mm/day, maximum temperatures 8–10 °C below normal, and wind gusts above 70 km/h. In this study, the atmospheric conditions during the event and its predictability on the weekly to subseasonal range are investigated. Results show that during the event, the tropical convective signal of the Madden-Julian Oscillation was over the western Pacific, and likely contributed to the heavy rainfall, however the El Niño-Southern Oscillation was not in the usual phase for increased rainfall over Queensland. Over the northern Tasman Sea, an anticyclone helped maintain a positive phase of the Southern Annular Mode and promote onshore easterly flow. Somewhat consistent with these climate drivers, the monthly rainfall outlook for February issued by the Australian Bureau of Meteorology on 31 January provided no indication of the event, yet forecasts, not available to the public, of weekly-averaged conditions by the Bureau's dynamical subseasonal-to-seasonal (S2S) prediction system were more successful. For the week of 31 January to 6 February the prediction system forecast a more than doubling of the probability of extreme (highest quintile) weekly rainfall a week prior to the event, along with increased probabilities of extremely low (lowest quintile) maximum temperatures and extreme (highest quintile) wind speeds. Ensemble-mean weekly rainfall amounts, however, were considerably underestimated by the prediction system, even in forecasts initialised at the start of the peak flooding week, consistent with other state-of-the-art dynamical S2S prediction systems. Despite this, one of the individual ensemble members of the Bureau's prediction system did manage to forecast close to 85% of the magnitude of the rainfall across the most heavily impacted region of northwest Queensland a week before the event. Predicting this exceptional event beyond two weeks appears beyond our current capability despite the dynamical system forecasts showing good skill in forecasting the broad-scale atmospheric conditions north of Australia a week prior

Interstellar CN and CH+ in Diffuse Molecular Clouds: 12C/13C Ratios and CN Excitation

We present very high signal-to-noise ratio absorption-line observations of CN and CH+ along 13 lines of sight through diffuse molecular clouds. The data are examined to extract precise isotopologic ratios of 12CN/13CN and 12CH+/13CH+ in order to assess predictions of diffuse cloud chemistry. Our results on 12CH+/13CH+ confirm that this ratio does not deviate from the ambient 12C/13C ratio in local interstellar clouds, as expected if the formation of CH+ involves nonthermal processes. We find that 12CN/13CN, however, can be significantly fractionated away from the ambient value. The dispersion in our sample of 12CN/13CN ratios is similar to that found in recent surveys of 12CO/13CO. For sight lines where both ratios have been determined, the 12CN/13CN ratios are generally fractionated in the opposite sense compared to 12CO/13CO. Chemical fractionation in CO results from competition between selective photodissociation and isotopic charge exchange. An inverse relationship between 12CN/13CN and 12CO/13CO follows from the coexistence of CN and CO in diffuse cloud cores. However, an isotopic charge exchange reaction with CN may mitigate the enhancements in 12CN/13CN for lines of sight with low 12CO/13CO ratios. For two sight lines with high values of 12CO/13CO, our results indicate that about 50 percent of the carbon is locked up in CO, which is consistent with the notion that these sight lines probe molecular cloud envelopes where the transition from C+ to CO is expected to occur. An analysis of CN rotational excitation yields a weighted mean value for T_01(12CN) of 2.754 +/- 0.002 K, which implies an excess over the temperature of the cosmic microwave background of only 29 +/- 3 mK. This modest excess eliminates the need for a local excitation mechanism beyond electron and neutral collisions. The rotational excitation temperatures in 13CN show no excess over the temperature of the CMB.Comment: 27 pages, 21 figures, emulateapj style, accepted for publication in Ap

Successful control of a hospital-wide outbreak of OXA-48 producing Enterobacteriaceae in the Netherlands, 2009 to 2011

On 31 May 2011, after notification of Klebsiella pneumoniae(KP)(OXA-48);(CTX-M-15) in two patients, nosocomial transmission was suspected in a Dutch hospital. Hospital-wide infection control measures and an outbreak investigation were initiated. A total of 72,147 patients were categorised into groups based on risk of OXA-48 colonisation or infection, and 7,527 were screened for Enterobacteriaceae(OXA-48) by polymerase chain reaction (PCR). Stored KP isolates (n=408) were retrospectively tested for OXA-48 and CTX-M-1 group extended-spectrum beta-lactamases (ESBL). 285 KP isolates from retrospective and prospective patient screening were genotyped by amplified fragment length polymorphism (AFLP). 41 isolates harbouring different Enterobacteriaceae species were analysed by plasmid multilocus sequence typing (pMLST). No nosocomial transmission of Enterobacteriaceae(OXA-48) was detected after 18 July 2011. Enterobacteriaceae(OXA-48) were found in 118 patients (KP (n=99), Escherichia coli (n=56), >= 1 Enterobacteriaceae(OXA-48) species (n=52)),of whom 21 had clinical infections. 39/41 (95%) of OXA-48 containing plasmids were identical in pMLST. Minimum inhibitory concentrations (MICs) of KPOXA-48 and E. coli(OXA-48) for imipenem and meropenem ranged from = 16 mg/L, and 153/157 (97%) had MIC >0.25mg/L for ertapenem. AFLP identified a cluster of 203 genetically linked isolates (62 KPOXA-48;(CTX-M15); 107 KPCTX-M-15; 34 KPOXA-48). The 'oldest' KPCTX-M-15 and KPOXA-48 clonal types originated from February 2009 and September 2010, respectively. The last presumed outbreak-related KPOXA-48 was detected in April 2012. Uncontrolled transmission of KP (CTX-M-15) evolved into a nosocomial outbreak of KPOXA-48; CTX-M15 with large phenotypical heterogeneity. Although the outbreak was successfully controlled, the contribution of individual containment measures and of the hospital relocating into a new building just before outbreak notification was impossible to quantify

Effects of correcting metabolic acidosis on muscle mass and functionality in chronic kidney disease:a systematic review and meta-analysis

Metabolic acidosis unfavourably influences the nutritional status of patients with non-dialysis dependent chronic kidney disease (CKD) including the loss of muscle mass and functionality, but the benefits of correction are uncertain. We investigated the effects of correcting metabolic acidosis on nutritional status in patients with CKD in a systematic review and meta-analysis. A search was conducted in MEDLINE and the Cochrane Library from inception to June 2023. Study selection, bias assessment, and data extraction were independently performed by two reviewers. The Cochrane risk of bias tool was used to assess the quality of individual studies. We applied random effects meta-analysis to obtain pooled standardized mean difference (SMD) and 95% confidence intervals (CIs). We retrieved data from 12 intervention studies including 1995 patients, with a mean age of 63.7 ± 11.7 years, a mean estimated glomerular filtration rate of 29.8 ± 8.8 mL/min per 1.73 m2, and 58% were male. Eleven studies performed an intervention with oral sodium bicarbonate compared with either placebo or with standard care and one study compared veverimer, an oral HCl-binding polymer, with placebo. The mean change in serum bicarbonate was +3.6 mEq/L in the intervention group and +0.4 mEq/L in the control group. Correcting metabolic acidosis significantly improved muscle mass assessed by mid-arm muscle circumference (SMD 0.35 [95% CI 0.16 to 0.54], P &lt; 0.001) and functionality assessed with the sit-to-stand test (SMD −0.31 [95% CI −0.52 to 0.11], P = 0.003). We found no statistically significant effects on dietary protein intake, handgrip strength, serum albumin and prealbumin concentrations, and blood urea nitrogen. Correcting metabolic acidosis in patients with CKD improves muscle mass and physical function. Correction of metabolic acidosis should be considered as part of the nutritional care for patients with CKD.</p

Assessing expertise using eye tracking in a Virtual Reality flight simulation

This is the final version. Available on open access from Routledge via the DOI in this recordAvailability of data, material and code : All relevant data and code is available online from: https://osf.io/c2tz9/Objective: The aim of this work was to examine the fidelity and validity of an aviation simulation using eye tracking. Background: Commercial head-mounted virtual reality (VR) systems offer a convenient and cost-effective alternative to existing aviation simulation (e.g., for refresher exercises). We performed pre-implementation testing of a novel aviation simulation, designed for head-mounted VR, to determine its fidelity and validity as a training device. Method: Eighteen airline pilots, with varying levels of flight experience, completed a sequence of training ‘flows’. Self reported measures of presence and workload and users’ perceptions of fidelity were taken. Pilots’ eye movements and performance were recorded to determine whether more experienced pilots showed distinct performance and eye gaze profiles in the simulation, as they would in the real-world. Results: Real-world expertise correlated with eye gaze patterns characterised by fewer, but longer, fixations and a scan path that was more structured and less random. Multidimensional scaling analyses also indicated differential clustering of strategies in more versus less experienced pilots. Subjective ratings of performance, however, showed little relationship with real-world expertise or eye movements. Conclusion: We adopted an evidence-based approach to assessing the fidelity and validity of a VR flight training tool. Pilot reports indicated the simulation was realistic and potentially useful for training, while direct measurement of eye movements was useful for establishing construct validity and psychological fidelity of the simulation