1,152 research outputs found

    Short versus long silver nanowires: a comparison of in vivo pulmonary effects post instillation.

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    BackgroundSilver nanowires (Ag NWs) are increasingly being used to produce touchscreens for smart phones and computers. When applied in a thin film over a plastic substrate, Ag NWs create a transparent, highly-conductive network of fibers enabling the touch interface between consumers and their electronics. Large-scale application methods utilize techniques whereby Ag NW suspensions are deposited onto substrates via droplets. Aerosolized droplets increase risk of occupational Ag NW exposure. Currently, there are few published studies on Ag NW exposure-related health effects. Concerns have risen about the potential for greater toxicity from exposure to high-aspect ratio nanomaterials compared to their non-fibrous counterparts. This study examines whether Ag NWs of varying lengths affect biological responses and silver distribution within the lungs at different time-points.MethodsTwo different sizes of Ag NWs (2 ÎĽm [S-Ag NWs] and 20 ÎĽm [L-Ag NWs]) were tested. Male, Sprague-Dawley rats were intratracheally instilled with Ag NWs (0, 0.1, 0.5, or 1.0 mg/kg). Broncho-alveolar lavage fluid (BALF) and lung tissues were obtained at 1, 7, and 21 days post exposure for analysis of BAL total cells, cell differentials, and total protein as well as tissue pathology and silver distribution.Results and conclusionsThe two highest doses produced significant increases in BAL endpoints. At Day 1, Ag NWs increased total cells, inflammatory polymorphonuclear cells (PMNs), and total protein. PMNs persisted for both Ag NW types at Day 7, though not significantly so, and by Day 21, PMNs appeared in line with sham control values. Striking histopathological features associated with Ag NWs included 1) a strong influx of eosinophils at Days 1 and 7; and 2) formation of Langhans and foreign body giant cells at Days 7 and 21. Epithelial sloughing in the terminal bronchioles (TB) and cellular exudate in alveolar regions were also common. By Day 21, Ag NWs were primarily enclosed in granulomas or surrounded by numerous macrophages in the TB-alveolar duct junction. These findings suggest short and long Ag NWs produce pulmonary toxicity; thus, further research into exposure-related health effects and possible exposure scenarios are necessary to ensure human safety as Ag NW demand increases

    Integration of Animal-Assisted Therapy Standards in Pediatric Occupational Therapy

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    The primary purpose of this study was to describe how the best practice recommendations and standards of practice related to animal-assisted therapy (AAT) are being incorporated into pediatric occupational therapy (OT). The study design was a nonexperimental survey that identified the qualifications of pediatric occupational therapists that are incorporating AAT, the AAT standards of practice that are or are not used in practice, and the barriers and facilitators to being an AAT qualified occupational therapist. There were 21 respondents to the survey. The majority of respondents had a master’s degree, more than 10 years working as an occupational therapist, less than 10 years of experience with AAT, and practiced in the inpatient rehabilitation setting. The data collected indicated that 2 out of the 13 standards of practice and none of the best practice recommendations are being implemented by 50% or more of respondents. The lack of education and awareness of the AAT standards of practice according to the professional organization Animal Assisted Intervention International and the actual role of volunteer organizations may be impacting the best practice implementations in pediatric occupational therapy practice

    Light-Scattering, Intrinsic Viscosity, and Gold Number Relationships for Some Dextran Fractions

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    Author Institution: Departments of Bacteriology and Chemistry, The Ohio State University, Columbus, Ohi
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