A survey of ergodic theorems

Thesis (M.A.)--Boston Universit

Investigation and quality assessment of the Past Weather Code from the Integrated Surface Database

Quantitative SYNOP Code weather variables such as rainfall amount, although of high societal and environmental importance, are frequently subject to recording errors and inhomogeneities resulting in uncertain conclusions. Here we assess the viability of the more qualitative Past Weather Code (PWC) for its use in robust climate analysis in the belief that it is less prone to both random and systematic errors. The Past Weather Code data, from a selection of the National Oceanographic and Atmospheric Administration’s Integrated Surface Database (ISD) (4731 sufficiently long stations), is quality assessed by searching for inhomogeneities in station PWC time series, removing the offending stations and averaging the remaining stations into a global gridded dataset. PWCs 6 (Rainfall), 7 (Snowfall) and 9 (Thunderstorms) are found to robustly exhibit seasonal features, e.g. the Indian monsoon and peak Northern Hemispheric winter snowfall. Precipitation responses to the North Atlantic Oscillation are also detected in winter PWC 6 data over Europe

Mapping the domains of CD134 as a functional receptor for feline immunodeficiency virus (FIV)

The feline homologue of CD134 (fCD134) is the primary binding receptor for feline immunodeficiency virus (FIV), targeting the virus preferentially to activated CD4+ helper T cells. However, strains of FIV differ in their utilisation of CD134; the prototypic strain PPR, requires a minimal determinant in CRD1 of fCD134 to confer near optimal receptor function while strains such as GL8 require additional determinants in the CD134 CRD2. We map this determinant to a loop in CRD2 governing the interaction between the receptor and its ligand; substitution of amino acids S78N,S79Y,K80E restored full viral receptor activity to the CDR2 of human CD134 in the context of feline CD134 with tyrosine-79 appearing to be the critical residue for restoration of receptor function