Filozofia Karola Wojtyły wobec problemu moderny

Specyfiką antropologii Karola Wojtyły jest synteza obiektywizmu i subiektywności, łączy on wątki aleteiczne i agapiczne. Akceptując nowożytny zwrot antropologiczny, z jednej strony, podejmuje w swych pracach próbę syntezy klasycznej filozofii bytu z filozofią świadomości, a z drugiej strony, dąży do korekty skrajnego antropo¬centryzmu myśli nowożytnej. Autor artykułu analizuje związek Wojtyły koncepcji świadomości i podmiotowości z personalistycznym stylem duszpasterstwa Jana Pawła II, głoszącego, że „człowiek jest podstawową drogą Kościoła”. Drugim filarem analizy jest pytanie o sens ludzkiej wolności. W myśli Wojtyły oraz w nauczaniu Jana Pawła II rozważania o wolności jako podstawowej właściwości bytu osoby łączą się z namysłem nad jej etycznym wymiarem.The specificity of Karol Wojtyla’s anthropology is the synthesis of objectivity and subjectivity, which combines alletic and agapical motives. On the one hand, by accepting the modern anthropological turn, he attempts to synthesize classical philosophy of being with the philosophy of consciousness, and on the other, he strives to correct the extreme anthropocentrism of modern thought. The author of the article analyzes Wojtyla’s relationship of awareness and subjectivity with the personal style of the pastoral ministry of John Paul II, who proclaimed man as “the main way of the Church”. The other pillar of analysis is the question about the meaning of human freedom. In Wojtyla’s thought and in the teachings of John Paul II, considerations about freedom as the basic property of human being are combined with a reflection on its ethical dimension

Multi-Objective Optimization in Negotiation Support

The paper reviews the methodology of multi-objective modeling and optimization used in decision support based on computerized analytical models (as opposed to logical models used in expert systems) that represent expert knowledge in a given field. The essential aspects of this methodology relate to its flexibility: modeling and optimization methods are treated not as goals in themselves but as tools that help a sovereign user (an analyst or a decision maker) to interact with the model, to generate and analyze various decision options, to learn about possible outcomes of these decisions. Although the application of such methods in negotiation and mediation support is scarce yet, their flexibility increases essentially the chances of such applications. Various aspects of negotiation and mediation methods related to multi-objective optimization and game theory are also reviewed

The Hippo pathway in colorectal cancer

Colorectal cancer (CRC) is one the most frequently diagnosed neoplastic diseases worldwide. Currently, aside from traditional chemotherapy, advanced CRCs are treated with modern drugs targeting cellular components such as epithelial growth factor receptor (EGFR). Since up to 70% of metastasized CRCs are drug resistant, the description of recent progress in cellular homeostasis regulation may shed new light on the development of new molecular targets in cancer treatment. The Hippo pathway has recently become subject of intense investigations since it plays a crucial role in cell proliferation, differentiation, apoptosis and tumourigenesis. Components of the Hippo pathway are deregulated in various human malignancies, and expression levels of its major signal transducers were proposed as prognostic factors in colorectal cancer. In this review we focused on recent data regarding Hippo pathway, its up-stream signals and down-stream effectors. Hippo negatively regulates its major effectors, YAP1 and TAZ kinases, which act as transcriptional co-activators inducing expression of genes involved not only in tissue repair and proliferation but are also oncoproteins involved in tumour development and progression. The deregulation of Hippo pathway components was found in many malignancies. The interactions between Hippo and Wnt/β-catenin signalling, crucial in the maintenance of cell homeostasis, have been described in relation to the control of intestinal stem cell proliferation and CRC development. The recently discovered positive feedback loop between activated YAP1 and increased EGFR/KRAS signalling found in oesophageal, ovarian and hepatocellular cancer has been related to the CRC progression and resistance to EGFR inhibitors during CRC therapy

Multiobjective and Stochastic Optimization

This book is divided into four main sections, the first of which contains five papers dealing with the theoretical aspects of multiobjective and stochastic optimization. The seven papers included in Section II are concerned with those aspects of multiobjective analysis which have a direct relationship to decision making (some papers in Sections III and IV are also linked to decision making or decision support, although not so directly). Section III contains four papers dealing with uncertainties and multiobjective analysis. The first and last papers in this section also present solution techniques which are illustrated by means of examples. The final section contains papers which concentrate on solution techniques and indicate how they can be applied to practical problems; the software presented in this section can be regarded as a step toward computerized decision support systems. Naturally, some of the papers in other sections also touch on applications of multiobjective and stochastic optimization: examples are drawn from a wide range of activities, including regional planning, environmental control, wage negotiation and energy planning