114 research outputs found
Evaluation of Schizosaccharomyces pombe as a model organism for structural studies on tripeptidyl peptidase II
Acute Pain and a Motivational Pathway in Adult Rats: Influence of Early Life Pain Experience
The importance of neonatal experience upon behaviour in later life is increasingly recognised. The overlap between pain and reward pathways led us to hypothesise that neonatal pain experience influences reward-related pathways and behaviours in adulthood
Recent advances in the structural biology of the 26S proteasome
There is growing appreciation for the fundamental role of structural dynamics in the function of macromolecules. In particular, the 26S proteasome, responsible for selective protein degradation in an ATP dependent manner, exhibits dynamic conformational changes that enable substrate processing. Recent cryo-electron microscopy (cryo-EM) work has revealed the conformational dynamics of the 26S proteasome and established the function of the different conformational states. Technological advances such as direct electron detectors and image processing algorithms allowed resolving the structure of the proteasome at atomic resolution. Here we will review those studies and discuss their contribution to our understanding of proteasome function. (C) 2016 The Authors. Published by Elsevier Ltd
Effects of post-weaning enrichment and isolation upon emotionality and brain weight in the mouse.
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