Superconductivity in the New Platinum Germanides MPt4Ge12 (M = Rare-earth and Alkaline-earth Metals) with Filled Skutterudite Structure

New germanium-platinum compounds with the filled-skutterudite crystal structure were synthesized. The structure and composition were investigated by X-ray diffraction and microprobe analysis. Magnetic susceptibility, specific heat, and electrical resistivity measurements evidence superconductivity in LaPt4Ge12 and PrPt4Ge12 below 8.3K. The parameters of the normal and superconducting states were established. Strong coupling and a crystal electric field singlet groundstate is found for the Pr compound. Electronic structure calculations show a large density of states at the Fermi level. Similar behavior with lower T_c was observed for SrPt4Ge12 and BaPt4Ge12.Comment: RevTeX, 4 figures, submitted to Physical Review Letters July 12, 200

Superconductivity in novel Ge-based skutterudites: {Sr,Ba}Pt_4Ge_{12}

Combining experiments and ab initio models we report on $\rm SrPt_4Ge_{12}$ and $\rm BaPt_4Ge_{12}$ as members of a novel class of superconducting skutterudites, where Sr or Ba atoms stabilize a framework entirely formed by Ge-atoms. Below $T_c=5.35$ K, and 5.10 K for $\rm BaPt_4Ge_{12}$ and $\rm SrPt_4Ge_{12}$, respectively, electron-phonon coupled superconductivity emerges, ascribed to intrinsic features of the Pt-Ge framework, where Ge-$p$ states dominate the electronic structure at the Fermi energy.Comment: 4 pages, 4 figures, accepted for publication in PR

DNA methylation in interleukin-11 predicts clinical response to antidepressants in GENDEP

Transcriptional differences in interleukin-11 (IL11) after antidepressant treatment have been found to correspond to clinical response in major depressive disorder (MDD) patients. Expression differences were partly mediated by a single-nucleotide polymorphism (rs1126757), identified as a predictor of antidepressant response as part of a genome-wide association study. Here we attempt to identify whether DNA methylation, another baseline factor known to affect transcription factor binding, might also predict antidepressant response, using samples collected from the Genome-based Therapeutic Drugs for Depression project (GENDEP). DNA samples from 113 MDD individuals from the GENDEP project, who were treated with either escitalopram (n=80) or nortriptyline (n=33) for 12 weeks, were randomly selected. Percentage change in Montgomery-� sberg Depression Rating Scale scores between baseline and week 12 were utilized as our measure of antidepressant response. The Sequenom EpiTYPER platform was used to assess DNA methylation across the only CpG island located in the IL11 gene. Regression analyses were then used to explore the relationship between CpG unit methylation and antidepressant response. We identified a CpG unit predictor of general antidepressant response, a drug by CpG unit interaction predictor of response, and a CpG unit by rs1126757 interaction predictor of antidepressant response. The current study is the first to investigate the potential utility of pharmaco-epigenetic biomarkers for the prediction of antidepressant response. Our results suggest that DNA methylation in IL11 might be useful in identifying those patients likely to respond to antidepressants, and if so, the best drug suited to each individual

How should we interpret the two transport relaxation times in the cuprates ?

We observe that the appearance of two transport relaxation times in the various transport coefficients of cuprate metals may be understood in terms of scattering processes that discriminate between currents that are even, or odd under the charge conjugation operator. We develop a transport equation that illustrates these ideas and discuss its experimental and theoretical consequences.Comment: 19 pages, RevTeX with 8 postscript figures included. To appear in ``Non Fermi Liquid Physics'', J. Phys:Cond. Matt. (1997

The impact of phenotypic and genetic heterogeneity on results of genome wide association studies of complex diseases

Phenotypic misclassification (between cases) has been shown to reduce the power to detect association in genetic studies. However, it is conceivable that complex traits are heterogeneous with respect to individual genetic susceptibility and disease pathophysiology, and that the effect of heterogeneity has a larger magnitude than the effect of phenotyping errors. Although an intuitively clear concept, the effect of heterogeneity on genetic studies of common diseases has received little attention. Here we investigate the impact of phenotypic and genetic heterogeneity on the statistical power of genome wide association studies (GWAS). We first performed a study of simulated genotypic and phenotypic data. Next, we analyzed the Wellcome Trust Case-Control Consortium (WTCCC) data for diabetes mellitus (DM) type 1 (T1D) and type 2 (T2D), using varying proportions of each type of diabetes in order to examine the impact of heterogeneity on the strength and statistical significance of association previously found in the WTCCC data. In both simulated and real data, heterogeneity (presence of "non-cases") reduced the statistical power to detect genetic association and greatly decreased the estimates of risk attributed to genetic variation. This finding was also supported by the analysis of loci validated in subsequent large-scale meta-analyses. For example, heterogeneity of 50% increases the required sample size by approximately three times. These results suggest that accurate phenotype delineation may be more important for detecting true genetic associations than increase in sample size

Observation of Magnetic Flux Generated Spontaneously During a Rapid Quench of Superconducting Films

We report observations of spontaneous formation of magnetic flux lines during a rapid quench of YBa$_{2}$Cu$_{3}$O$_{7-\delta}$ films through T$_{c}$. This effect is predicted according to the Kibble-Zurek mechanism of creation of topological defects of the order parameter during a symmetry-breaking phase transition. Our previous experiment, at a quench rate of 20K/sec, gave null results. In the present experiment, the quench rate was increased to \TEXTsymbol{>} 10$^{8}$ K/sec. Within experimental resolution, the dependence of the measured flux on the cooling rate is consistent with the prediction

Femtosecond optical absorption studies of nonequilibrium electronic processes in high Tc superconductors

We report the results of femtosecond optical transient absorption experiments performed on the superconducting compounds YBa2Cu3O7−x(x ∼ 0) and Bi2Sr2Ca2Cu3O10+δ(δ ∼ 0) and nonsuperconducting YBa2Cu3O6+y(y<0.4) for sample temperatures ranging from ∼7 K to room temperature. Nonequilibrium heating was found to occur on a subpicosecond time scale. A distinct, dramatic increase in the relaxation time was observed for the superconducting samples as the sample temperature was lowered below the critical temperatures of the respective films. Accompanying the increase in relaxation time was an increase in the peak fractional transmissivity change. No such changes were observed for the nonsuperconducting YBCO sample. We believe the above described behavior is electronic in origin and intimately related to the superconductivity of the compounds.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/69780/2/APPLAB-57-16-1696-1.pd