1,495 research outputs found
Designing Guidelines to Discover Causes of Delays in Construction Projects: The Case of Lebanon
Construction projects in developing countries have the priority among other projects as they are considered safe investments in an unpredictable market. Due to this prioritization, it has become increasingly important that such projects are managed in accordance with internationally accepted management best practice. Project managers of construction projects in developing countries face difficulties in effectively monitoring the progress of projects they are responsible for due to many variables. The purpose of this study is to investigate the causes of delays in the construction projects that were covered in the considered literature and conduct qualitative research to investigate their relevance by interviewing project managers of actual projects in Lebanon. Based on the literature review and from the recommendations recorded during interviews, the researcher aims to create a set of guidelines that will improve the manner in which project managers can adapt to, discover and deal with project delays. These guidelines can be utilized as an early warning system concerning delays in construction projects
Differences in intention to use educational RSS feeds between Lebanese and British students: A multi‑group analysis based on the technology acceptance model
Really Simple Syndication (RSS) offers a means for university students to receive timely updates from virtual learning environments. However, despite its utility, only 21% of home students surveyed at a university in Lebanon claim to have ever used the technology. To investigate whether national culture could be an influence on intention to use RSS, the survey was extended to British students in the UK. Using the Technology Adoption Model (TAM) as a research framework, 437 students responded to a questionnaire containing four constructs: behavioral intention to use; attitude towards benefit; perceived usefulness; and perceived ease of use. Principle components analysis and structural equation modelling were used to explore the psychometric qualities and utility of TAM in both contexts. The results show that adoption was significantly higher, but also modest, in the British context at 36%. Configural and metric invariance were fully supported, while scalar and factorial invariance were partially supported. Further analysis shows significant differences between perceived usefulness and perceived ease of use across the two contexts studied. Therefore, it is recommended that faculty demonstrate to students how educational RSS feeds can be used effectively to increase awareness and emphasize usefulness in both contexts
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Towards the acceptance of RSS to support learning: An empirical study to validate the technology acceptance model in Lebanon
Simpler is better. There are a lot of "needs" in e-Learning, and there's often a limit to the time, talent, and money that can be thrown at them individually. Contemporary pedagogy in technology and engineering disciplines, within the higher education context, champion instructional designs that emphasize peer instruction and rich formative feedback. However, it can be challenging to maintain student engagement outside the traditional classroom environment and ensure that students receive feedback in time to help them with ongoing assignments. The use of virtual learning platforms, such as Blackboard Learn, and web feed syndication, using technology such as Rich Site Summaries (RSS), can help overcome such challenges. However, during an initial pilot at an institution in Lebanon, only 21% of students reported making use of both these facilities. In this study, the Technology Acceptance Model (TAM) was used to guide the development of a scale to be used to investigate antecedents to the use of web feeds. The proposed scale was reviewed by 4 experts and piloted with 235 students. The collected data were analysed using structural equation modeling (SEM) technique based on AMOS methods. The results revealed adequate face, content, and construct validity. However, perceived ease of use was not a significant predictor of attitude towards use. Overall, the proposed model achieves acceptable fit and explains for 38% of its variance of which is lower than that of the original TAM. This suggests that aspects of the model may lack criterion validity in the Lebanese context. Consequently, it may be necessary to extend the scale by capturing additional moderators and predictors, such as cultural values and subjective norms. We concluded that the existence of RSS feeds in education improves significantly the content presented by the instructors to the e-learning user decreasing at the same time the size and access cost
An Empirical Analysis of the Seasonal Patterns in Aggregate Directors’ Trades
This paper examins the seasonal patterns in aggregate insider trading transactions, specifically, do insiders prefer to trade on any particular day of the week or month of the year? It also, given that such seasonal patterns exist, attempts to relate these patterns to explanations drawn from the literature on calendar anomalies in returns (and volumes). The results outlined from this paper includes: There is a day of the week anomaly in aggregate insider activities (as measured by number and value of insider transactions). Particularly, relative to other days, insiders tend to trade more on Fridays and less on Tuesdays. Also, the distribution of the average value of directors‟ trades (buys and sells) across the week days forms a U shape i.e. high trading value on the beginning of the week (Monday) and the end of the week (Friday). Also, there is a month of the year anomaly in aggregate insider activities (as measured by the number of insider transactions). Insiders tend to trade most frequently in March and least in August. The results of OLS Regression Model indicate that there is no monthly anomaly in aggregate insider selling activities as measured by the aggregate value of insider transactions. The results of TOBIT Regression Model show that the average value of directors‟ selling activities in March is higher and significantly different relative to other months of the year. The results of OLS regression are also confirmed by the results of K-W statistic test which supported the non existence of monthly anomaly in aggregate director trading (measured by the value of director transactions)
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A cross-cultural study of the intention to use mobile banking between Lebanese and British consumers: Extending UTAUT2 with security, privacy and trust
This study aims to examine the key factors that may hinder or facilitate the adoption of mobile banking services in a cross-cultural context. A conceptual framework was developed through extending the Unified Theory of Acceptance and Use of Technology UTAUT2 by incorporating three additional constructs, namely trust (TR), security (PS) and privacy (PP). Data were collected using an online survey and a self-administrated questionnaire from 901 mobile banking users who were either Lebanese or English. These were analysed using structural equation modelling based on AMOS 23.0. The results of this analysis indicated that behavioural intention towards adoption of mobile banking services was influenced by habit (HB), perceived security (PS), perceived privacy (PP) and trust (TR) for both the Lebanese and English consumers. In addition, performance expectancy (PE) was a significant predictor in Lebanon but not in England; whereas price value (PV) was significant in England but not in Lebanon. Contrary to our expectation, Social Influence (SI) and Hedonic Motivations (HM) were insignificant for both the Lebanese and English consumers. Overall, the proposed model achieved acceptable fit and explained 78% of the variance for the Lebanese sample and 83% for the English sample – both of which are higher than that of the original UTAUT2. These findings are expected to help policy makers and bank directors understand the issues facing mobile banking adoption in different cultural settings. Subsequently, they will help guide them in formulating appropriate strategies to improve the uptake of mobile banking activities. As the low mobile banking adoption rate in Lebanon can be attributed to the novelty of this technology, the Lebanese banking sector stands to greatly benefit from this study
Examining the moderating effect of individual-level cultural values on users’ acceptance of E-learning in developing countries: a structural equation modeling of an extended technology acceptance model
In this study, we examine the effects of individual-level culture on the adoption and acceptance of e-learning tools by students in Lebanon using a theoretical framework based on the Technology Acceptance Model (TAM). To overcome possible limitations of using TAM in developing countries, we extend TAM to include subjective norms (SN) and quality of work life constructs as additional constructs and a number of cultural variables as moderators. The four cultural dimensions of masculinity/femininity (MF), individualism/collectivism, power distance and uncertainty avoidance were measured at the individual level to enable them to be integrated into the extended TAM as moderators and a research model was developed based on previous literature. To test the hypothesised model, data were collected from 569 undergraduate and postgraduate students using e-learning tools in Lebanon via questionnaire. The collected data were analysed using the structural equation modelling technique in conjunction with multi-group analysis. As hypothesised, the results of the study revealed perceived usefulness (PU), perceived ease of use (PEOU), SN and quality of work life to be significant determinants of students’ behavioural intention (BI) towards e-learning. The empirical results also demonstrated that the relationship between SN and BI was particularly sensitive to differences in individual-cultural values, with significant moderating effects observed for all four of the cultural dimensions studied. Some moderating effects of culture were also found for both PU and PEOU, however, contrary to expectations the effect of quality of work life was not found to be moderated by MF as some previous authors have predicted. The implications of these results to both theory and practice are explored in the paper
An empirical examination of the moderating role of age and gender in consumer mobile banking use: a cross-national, quantitative study
Purpose
Despite the benefits of mobile banking services in an increasingly digitised world, adoption rates remain unsatisfactory. The present cross-national study examines age- and gender-dependent variations of consumer intentions and use of mobile banking services.
Design/methodology/approach
The study analyses consumer mobile banking use by integrating factors such as with trust, security and privacy and it examines the effects of these factors among two demographic factors including age and gender. 897 Lebanese and British mobile banking users completed a survey. Data was analysed by partial least squares-structural equations modelling.
Findings
Consumer behavioural intention was significantly moderated by age through its relationship with facilitating conditions and trust among Lebanese respondents, and performance expectancy, effort expectancy, hedonic motivation, price value and habit among their British counterparts. As for gender, a significant moderating effect was evidenced in the Lebanese, but not the British sample, on the level of performance expectancy, effort expectancy, facilitating conditions, price value and perceived security.
Originality/value
The findings provide evidence of the applicability of the new factors proposed in this research. The reflection of the influence of these demographic factors in a cross-national context provides insights into mobile banking adoption variation between different countries
Immune monitoring of the circulation and the tumor microenvironment in patients with regionally advanced melanoma receiving neoadjuvant ipilimumab
We evaluated neoadjuvant ipilimumab in patients with surgically operable regionally advanced melanoma in order to define markers of activity in the blood and tumor as assessed at baseline (before ipilimumab) and early on-treatment. Patients were treated with ipilimumab (10 mg/kg intravenously every 3 weeks x2 doses) bracketing surgery. Tumor and blood biospecimens were obtained at baseline and at surgery. Flow cytometry and immunohistochemistry for select biomarkers were performed. Thirty five patients were enrolled; IIIB (3; N2b), IIIC (32; N2c, N3), IV (2). Worst toxicities included Grade 3 diarrhea/colitis (5; 14%), hepatitis (2; 6%), rash (1; 3%), elevated lipase (3; 9%). Median follow up was 18 months: among 33 evaluable patients, median progression free survival (PFS) was 11 months, 95% CI (6.2-19.2). There was a significant decrease in circulating myeloid derived suppressor cells (MDSC). Greater decrease in circulating monocyte gate MDSC Lin1-/HLA-DR-/CD33+/CD11b+ was associated with improved PFS (p = 0.03). There was a significant increase in circulating regulatory T cells (Treg; CD4+CD25hi+Foxp3+) that, unexpectedly, was associated with improved PFS (HR = 0.57; p = 0.034). Baseline evidence of fully activated type I CD4+ and CD8+ antigen-specific T cell immunity against cancer-testis (NY-ESO-1) and melanocytic lineage (MART-1, gp100) antigens was detected and was significantly potentiated after ipilimumab. In tumor, there was a significant increase in CD8+ T cells after ipilimumab (p = 0.02). Ipilimumab induced increased tumor infiltration by fully activated (CD69+) CD3+/CD4+ and CD3 +/CD8+ T cells with evidence of induction/potentiation of memory T cells (CD45RO+). The change in Treg observed within the tumor showed an inverse relationship with clinical benefit and greater decrease in tumor MDSC subset Lin1-/HLA-DR-/CD33+/CD11b+ was associated with improved PFS at one year. Neoadjuvant evaluation revealed a significant immunomodulating role for ipilimumab on Treg, MDSC and effector T cells in the circulation and tumor microenvironment that warrants further pursuit in the quest for optimizing melanoma immunotherapy. © 2014 Tarhini et al
The helicase HAGE prevents interferon-a-induced PML expression in ABCB5+ malignant melanoma-initiating cells by promoting the expression of SOCS1
The tumour suppressor PML (promyelocytic leukaemia protein) regulates several cellular pathways involving cell growth, apoptosis, differentiation and senescence. PML also has an important role in the regulation of stem cell proliferation and differentiation. Here, we show the involvement of the helicase HAGE in the transcriptional repression of PML expression in ABCB5 + malignant melanoma-initiating cells (ABCB5 + MMICs), a population of cancer stem cells which are responsible for melanoma growth, progression and resistance to drug-based therapy. HAGE prevents PML gene expression by inhibiting the activation of the JAK-STAT (janus kinase-signal transducers and activators of transcription) pathway in a mechanism which implicates the suppressor of cytokine signalling 1 (SOCS1). Knockdown of HAGE led to a significant decrease in SOCS1 protein expression, activation of the JAK-STAT signalling cascade and a consequent increase of PML expression. To confirm that the reduction in SOCS1 expression was dependent on the HAGE helicase activity, we showed that SOCS1, effectively silenced by small interfering RNA, could be rescued by re-introduction of HAGE into cells lacking HAGE. Furthermore, we provide a mechanism by which HAGE promotes SOCS1 mRNA unwinding and protein expression in vitro
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