Modeling of Berm Formation and Erosion at the Southern Coast of the Caspian Sea

Cross-shore beach profile data from field measurements performed at six locations on the southern coast of the Caspian Sea are used to investigate bathymetry change due to various wave conditions. Beach profile measurements are analyzed and subsequently compared with the results of a berm formation and erosion model. The model comprises distinct empirical sediment transport equations for predicting the cross-shore sediment transport rate under various wave conditions. To yield a berm formation and erosion model, empirical cross-shore sediment transport equations are combined with the mass conservation equation. Simulations results obtained from the model compared well with the measurements, proving the capability of the model in simulating berm formation and erosion evolution

Closure or Non-Closure of Peritoneum in Cesarean Section: Outcomes of Short-Term Complications

Background: Cesarean section (CS) is one of the most frequently performed surgical procedures worldwide. The complications following a CS include fever, wound infection, post-operative pain and bleeding which are not usually found in a normal vaginal delivery. Traditionally, suturing of peritoneal layers for CS patients has been done, but in some studies it has been shown that this procedure could be eliminated without affecting the rate of morbidity. Objectives: The objective of this study was to assess the short-term outcomes of two different cesarean delivery techniques. Patients and Methods: A total of 100 cases who underwent CS were randomly assigned equally to either closure of both the visceral and parietal peritoneum or no peritoneum closure. Duration of operation, pain scores, analgesic requirements, alterations in hemoglobin levels and febrile morbidity were assessed accordingly. Results: Pain scores, analgesic requirements assessed at 24 hours and operation duration were significantly lower in the non-closure group as compared to the closure group. Febrile conditions and changes in hemoglobin levels were similar in both groups. Conclusions: Non-closure of both visceral and the parietal peritoneum when performing a CS produces a significant reduction in pain, fewer analgesic requirements and a shorter operation duration without increasing the febrile morbidity and changes in hemoglobin levels as compared to the standard methods

Influence of 1 Alpha, 25-Dihydroxyvitamin D3 on T helper 17 cells and related cytokines in systemic lupus erythematosus

Background: Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease. Emerging data suggests that T helper 17 (Th17) cells play a pathogenic role in SLE and the increased number of these cells correlates with disease activity. In recent years, 1α, 25-dihydroxyvitamin D3 (1,25VitD3) has been considered as an immunomodulatory factor. Objective: To investigate the effect of 1,25VitD3 on Th17 cells and on the expression of related cytokines in SLE patients. Method: Thirty SLE patients (newly diagnosed or in remission) were sampled for 10 ml whole blood to isolate peripheral blood mononuclear cells (PBMCs) using Ficoll-Hypaque density gradient centrifugation. Isolated cells were cultured in the presence and absence of 50 nM 1,25VitD3. After incubation, cells were harvested and stimulated for 4-5 hours with phorbol myristate acetate (PMA) and ionomycin in the presence of brefeldin A. IL-17 secreting cells were analyzed by flowcytometry. RNA was extracted from cultured cells, cDNA was synthesized, and the expression levels of IL-6, IL-17, IL-23 and TGF-β genes were assessed by real-time PCR. Results: The percentage of Th17 cells (CD3+CD8- IL-17+ T cells) decreased significantly in 1,25VitD3-treated cells (3.67 ± 2.43%) compared to untreated cells (4.65 ± 2.75%) (p=0.003). The expression of TGF-β up regulated (1.38-fold) and the expression of IL-6 (50%), IL-17 (27%) and IL-23 (64%) down regulated after 1,25VitD3 treatment. Conclusion: This study showed that 1,25VitD3 modulates Th17 related pathways in SLE patients and revealed the immunomodulatory effect of 1,25VitD3 on the Th17 mediated autoimmunity. © 2015, Shiraz University of Medical Sciences. All rights reserved

Comparing the effects of vaginal misoprostol, laminaria, and extra amniotic saline infusion on cervical ripening and induction of labor

Objective This study aimed to compare the effects of vaginal misoprostol, laminaria, and extra-amniotic saline infusion (EASI) on cervical ripening. Methods This randomized controlled trial was conducted on 195 women with singleton pregnancies and unripe cervices. Participants were randomly allocated to 3, 65-person groups: a misoprostol, a laminaria, and an EASI group. The interventions in the misoprostol, laminaria, and EASI groups included a single 25-μg vaginal misoprostol suppository, an intracervical laminaria, and a transcervical Foley catheter, respectively. The groups were compared with each other regarding time intervals from labor induction to labor active phase and delivery, cervical dilation, Bishop scores 6 hours after induction, delivery type, length of hospital stay, and complications. Results There were no significant differences among the groups regarding maternal ages, gestational ages, body mass indices, baseline cervical dilations, and Bishop scores (P>0.05). Six hours after induction, the Bishop score and cervical dilation were significantly greater in the EASI group than in the other 2 groups (P<0.001). Moreover, time intervals from labor induction to labor active phase and delivery in the EASI group were significantly short (P<0.001). The rates of cesarean section, fetal distress, placental abruption, and meconium staining in the misoprostol group were significantly high (P<0.05), and the length of hospital stay in the EASI group was significantly short (P<0.001). Conclusion EASI is a safer and more effective method for cervical ripening. Considering its inexpensiveness, easy accessibility, and greater effectiveness, EASI is recommended for cervical ripening. Trial Registration Iranian Center for Clinical Trials Identifier: IRCT20170513033941N39. © 2020 Korean Society of Obstetrics and Gynecology

Banishayban in the Islamic era

Genealogists have related BaniShayban origin from Mosni-bin HarithaShaybani to prophet’s 19th ancestor called Nazar. Mosni-bin HarithaShaybani was a significant character who played a basic role in the events of early Islam. He managemd to earn reputation among Arabs due to his victory over the army of Iran in Zuqar battle, so that the first and second caliphs let him attack Iranian borders with other Islamic commanders.In addition to Zuqar battle under commandment of Mosni-bin HarithaShaybani, BaniShayban tribe had several battles with Shahrbaraz, Iranian self-styled king, including battle of chains and battle of Ullais during 11 to 14 A.H years. They participated in battle of the bridge with Abu Obadiah, another commander of the Muslim Arabs. They were also present at the battle of Boveib. The commander of Shaybanis attended the battle of al-Qādisiyyah with several injuries on his body and wished to participate in the battle of Jalula, but his life came to its end before that.In the days of Imam Ali, Shaybanis helped him and were his commanders, particularly in the  battle of Siffin, because of being allied with the descendants of Abu Talib. Although some of them stood against Imam Ali, some others lost their lives guilty of friendship with him. They acquired high positions at the time of Umayyad and Bani Abbas and were even appointed in Armenia.The most important question is whether Shaybanis had any relationships with caliphs in early Islam; what role did they play in early Muslim conquests; and what positions were they assigned in the early centuries of Islam? The present study investigates the role of Shaybanis in Islamic era, particularly during early Islam as well as Umayyad and Bani Abbas reign.Keywords: BaniShayban, Mosni-bin Haritha, Iranian army, Umayyad, Bani Abba

Survey of behavioral problems and sensory processing in children with attention deficit/hyperactivity disorder

Objectives: All individuals need to have the ability of appropriate sensory processing for proper functioning in the environment and participation in daily activities. Moreover, behavioral functions can be affected by sensory processing problems. This study aimed to determine the relationship between behavioral problems and sensory processing in 7 to 10 years old children with Attention Deficit/Hyperactivity Disorder (ADHD). Methods: This descriptive (cross-sectional) study included 60 children with ADHD aged 7 to 10 years, who were referred to a comprehensive psychiatric center. Short Sensory Profile (SSP) and Child Behavior Checklist (CBCL) questionnaires were used for assessing the patterns of sensory processing and behavioral problems in the patients. Results: There was a negative correlation between internalizing behavioral problems (r=-0.426) and externalizing behavioral problems (r=-0.465), and the total score of sensory processing in ADHD children (P<0.05). Discussion: The findings of this study showed that some behaviors in children with ADHD could be due to certain defects in their sensory processing

Obstructive sleep apnea syndrome and non-arteritic anterior ischemic optic neuropathy: A case control study

Background: Sleep apnea is temporary cessation or absence of breathing during sleep. Significant increase in blood pressure is clinically seen in apneic episodes. The aim of this study was to examine sleep apnea syndrome as a risk factor for non- arthritic anterior ischemic optic neuropathy (NAION) in a case control study. Methods: Nineteen NAION patients (9 men and 10 women) and 31 age and sex matched control participants (18 men and 13 women) were evaluated for obstructive sleep apnea syndrome (OSAS). Full night polysomnography was performed and proportion of OSAS was compared between the NAION patients and the control group. Other risk factors for NAION such as hypertension, diabetes, hyperlipidemia, ischemic heart disease and tobacco consumption were also evaluated. Chi square test and independent samples t-test were used for statistical analysis. Results: OF the 19 NAION patients, 18 (95) had OSAS, and of the control group 13 (41.9) had OSAS. The frequency of OSAS was significantly higher among NAION patients compared to the controls (p < 0.001). The Mean Respiratory Disturbance Index (RDI) was 37.65/h SD = 37.61/h in NAION patients and it was 15.05/h SD = 11.97/h (p = 0.018) in controls. The frequency of diabetes and hypertension was significantly higher in the NAION patients than in controls. Conclusion: based on the results of this study, it seems that there is an association between NAION and OSAS

Systemic oncolytic adenovirus delivered in mesenchymal carrier cells modulate tumor infiltrating immune cells and tumor microenvironment in mice with neuroblastoma.

Celyvir (autologous mesenchymal cells -MSCs- that carry an oncolytic adenovirus) is a new therapeutic strategy for metastatic tumors developed by our research group over the last decade. There are limitations for studying the immune effects of human oncolytic adenoviruses in murine models since these viruses do not replicate naturally in these animals. The use of xenografts in immunodeficient mice prevent assessing important clinical aspects of this therapy such as the antiadenoviral immune response or the possible intratumoral immune changes, both of tumor infiltrating leukocytes and of the microenvironment. In our strategy, the presence of MSCs in the medicinal product adds an extra level of complexity. We present here a murine model that overcomes many of these limitations. We found that carrier cells outcompeted intravenous administration of naked particles in delivering the oncolytic virus into the tumor masses. The protection that MSCs could provide to the oncolytic adenovirus did not preclude the development of an antiadenoviral immune response. However, the presence of circulating antiadenoviral antibodies did not prevent changes detected at the tumor masses: increased infiltration and changes in the quality of immune cells per unit of tumor volume, and a less protumoral and more inflammatory profile of the tumor microenvironment. We believe that the model described here will enable the study of crucial events related to the immune responses affecting both the medicinal product and the tumor

Safety and Efficacy of MLC601 in Iranian Patients after Stroke: A Double-Blind, Placebo-Controlled Clinical Trial

Objective. To investigate the safety and efficacy of MLC601 (NeuroAid) as a traditional Chinese medicine on motor recovery after ischemic stroke. Methods. This study was a double-blind, placebo-controlled clinical trial on 150 patients with a recent (less than 3 month) ischemic stroke. All patients were given either MLC601 (100 patients) or placebo (50 patients), 4 capsules 3 times a day, as an add-on to standard stroke treatment for 3 months. Results. Sex, age, elapsed time from stroke onset, and risk factors in the treatment group were not significantly different from placebo group at baseline (P > .05). Repeated measures analysis showed that Fugl-Meyer assessment was significantly higher in the treatment group during 12 weeks after stroke (P < .001). Good tolerability to treatment was shown, and adverse events were mild and transient. Conclusion. MLC601 showed better motor recovery than placebo and was safe on top of standard ischemic stroke medications especially in the severe and moderate cases

Quantitative evaluation of rainbow trout, Oncorhynchus mykiss cultured in brackishwater and freshwater of Yazd province, at the based on muscle

Fish culture has developed in Yazd province of Iran since recent decade and the rainbow trout, Oncorhynchus mykiss is the most important fisheries product in the area. There is a few information about carcass composition of cultured fish in Iran. Rainbow trout samples were collected from 6 fish brackish and fresh water fish farms of Yazd province during February 2007. Fish muscle samples were freezed in -30 C after being homogenized, till laboratory analyses. Proximate composition of samples contained 17.05-18.53% crude protein, 2.35-5.13% total fat, 1.31-1.7% ash and 74.18-77.05% wet. Saturated fatty acids including palmitic acid (14.06-19.60%), stearic acid (6.44-6.1%), myristic acid (1.29-5.66%) and lauric acid (0.13-2.76), also unsaturated fatty acids oleic (30.24-40.14%) and linoleic (21.18-38.85%) were extracted from muscle tissue of fish of different farms, using GC. Other unsaturated fatty acids including -linolenic acid, EPA and DHA had low concentrations (1-3%) in samples. Vitamin E level was 4.33-94.34 g/100gr. Concentration of minerals in homogenated muscle tissues were as: Na 822.58-1052.78ppm, K 12272.75-13715.25ppm, Ca 104.75-171.03ppm, Fe 19-40ppm, Cu 0.044- 1.01ppb, Zn 7.02-12.47ppb, Cd 0.879-1.099ppb and Cr 1.895-3.86ppb. Heavy metal concentrations were lower than permitted values