Combined risk factors for melanoma in a Mediterranean population

A case–control study of non-familial melanoma including 183 incident cases and 179 controls was conducted in North-Eastern Italy to identify important risk factors and determine how combination of these affects risk in a Mediterranean population. Presence of dysplastic nevi (OR = 4.2, 95% CI = 2.4–7.4), low propensity to tan (OR = 2.4, 95% CI = 1.1–5.0), light eye (OR = 2.4, 95% CI = 1.1–5.2), and light skin colour (OR = 4.1, 95% CI = 1.4–12.1) were significantly associated with melanoma risk after adjustment for age, gender and pigmentation characteristics. A chart which identifies melanoma risk associated with combinations of these factors is presented; it can be used to identify subjects who would most benefit from preventive measures in Mediterranean populations. According to the combination of these factors, a relative risk range from 1 to 98.5 was found. Light skin colour, high number of sunburns with blistering, and low propensity to tan were significantly associated with melanoma thickness, possibly indicating that individuals with these characteristics underestimate their risk and seek attention when their lesion is already advanced. © 2001 Cancer Research Campaig

Broad band time-resolved E_{p,i}--L_{iso} correlation in GRBs

We report results of a systematic study of the broad band (2--2000 keV) time resolved prompt emission spectra of a sample of gamma-ray bursts (GRBs) detected with both Wide Field Cameras on board the \sax\ satellite and the \batse\ experiment on board CGRO. In this first paper, we study the time-resolved dependence of the intrinsic peak energy $E_{p,i}$ of the $E F(E)$ spectrum on the corresponding isotropic bolometric luminosity $L_{\rm iso}$. The $E_{p,i}$--$L_{\rm iso}$ relation or the equivalent relation between $E_{p,i}$ and the bolometric released energy $E_{iso}$, derived using the time averaged spectra of long GRBs with known redshift, is well established, but its physical origin is still a subject of discussion. In addition, some authors maintain that these relations are the result of instrumental selection effects. We find that not only a relation between the measured peak energy $E_p$ and the corresponding energy flux, but also a strong $E_{p,i}$ versus $L_{\rm iso}$ correlation are found within each burst and merging together the time resolved data points from different GRBs. We do not expect significant instrumental selection effects that can affect the obtained results, apart from the fact that the GRBs in our sample are sufficiently bright to perform a time-resolved spectroscopy and that they have known redshift. If the fundamental physical process that gives rise to the GRB phenomenon does not depend on its brightness, we conclude that the found $E_{p,i}$ versus $L_{\rm iso}$ correlation within each GRB is intrinsic to the emission process, and that the correlations discovered by Amati et al. and Yonetoku et al. are likely not the result of selection effects. We also discuss the properties of the correlations found.Comment: 27 pages,4 tables, 7 figure, accepted for publication in The Astrophysical Journa

Hyperaccurate thermoelectric currents

Thermodynamic currents, such as energy, heat, and entropy production, can fluctuate significantly at the nanoscale. However, some fluctuate less than others. Hyperaccurate currents are defined as those which fluctuate the least, in the sense that they maximize the signal-to-noise ratio (precision). In this Letter we analytically determine what are the hyperaccurate currents in quantum thermoelectrics, modeled by coherent transport in the Landauer-Büttiker formalism. Our results yield a tight and general bound on precision, which replace the classical thermodynamic uncertainty relations, that can be violated in quantum thermoelectrics. They also allow us to address the question of how close to hyperaccurate is a given current. We illustrate our findings for smooth boxcar functions, and for a double quantum dot operating as a thermal machine. In the latter, we use our results to establish the parameter ranges for which the output power of an autonomous engine can become hyperaccurate arbitrarily far from equilibrium

Joint fluctuation theorems for sequential heat exchange

We study the statistics of heat exchange of a quantum system that collides sequentially with an arbitrary number of ancillas. This can describe, for instance, an accelerated particle going through a bubble chamber. Unlike other approaches in the literature, our focus is on the \emph{joint} probability distribution that heat $Q_1$ is exchanged with ancilla 1, heat $Q_2$ is exchanged with ancilla 2, and so on. This allows one to address questions concerning the correlations between the collisional events. The joint distribution is found to satisfy a Fluctuation theorem of the Jarzynski-W\'ojcik type. Rather surprisingly, this fluctuation theorem links the statistics of multiple collisions with that of independent single collisions, even though the heat exchanges are statistically correlated