Obesity Hypertension: The Regulatory Role of Leptin

Leptin is a 16-kDa-peptide hormone that is primarily synthesized and secreted by adipose tissue. One of the major actions of this hormone is the control of energy balance by binding to receptors in the hypothalamus, leading to reduction in food intake and elevation in temperature and energy expenditure. In addition, increasing evidence suggests that leptin, through both direct and indirect mechanisms, may play an important role in cardiovascular and renal regulation. While the relevance of endogenous leptin needs further clarification, it appears to function as a pressure and volume-regulating factor under conditions of health. However, in abnormal situations characterized by chronic hyperleptinemia such as obesity, it may function pathophysiologically for the development of hypertension and possibly also for direct renal, vascular, and cardiac damage

Allez Neanderthal

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/62987/1/289823a0.pd

FAP106 is an interaction hub for assembling microtubule inner proteins at the cilium inner junction

Abstract Motility of pathogenic protozoa depends on flagella (synonymous with cilia) with axonemes containing nine doublet microtubules (DMTs) and two singlet microtubules. Microtubule inner proteins (MIPs) within DMTs influence axoneme stability and motility and provide lineage-specific adaptations, but individual MIP functions and assembly mechanisms are mostly unknown. Here, we show in the sleeping sickness parasite Trypanosoma brucei, that FAP106, a conserved MIP at the DMT inner junction, is required for trypanosome motility and functions as a critical interaction hub, directing assembly of several conserved and lineage-specific MIPs. We use comparative cryogenic electron tomography (cryoET) and quantitative proteomics to identify MIP candidates. Using RNAi knockdown together with fitting of AlphaFold models into cryoET maps, we demonstrate that one of these candidates, MC8, is a trypanosome-specific MIP required for parasite motility. Our work advances understanding of MIP assembly mechanisms and identifies lineage-specific motility proteins that are attractive targets to consider for therapeutic intervention

Kerionlike lesion of the scalp due to Acremonium kiliense in a noncompromised boy Lesão tipo quério do couro cabeludo causada por Acremonium kiliense em menino não imunocomprometido

We report a case of kerionlike lesion of the scalp due to Acremonium kiliense in a boy without underlying disease. Diagnosis was established by direct examination and cultures from pus and scrapings.<br>Relatamos um caso de lesão tipo quério do couro cabeludo causada por Acremonium kiliense, em menino sem doença de base. O diagnóstico foi feito pelo exame direto e cultivos do pus e crostas