A Mathematical Study of Glaucoma Using Machine Learning Algorithms for Retina

Glaucoma is a category of visual disorders represented by optic nerve neuropathy, a means of gradually declining optic nerve neuropathy. In-ground vision, resulting in sight loss. In this article, a novel retinal therapeutic support vector machine for glaucoma using machine Algorithms for learning is conservative. The algorithm has sufficient pragmatism; the correlation clustering mode is subsequently retained the estimated preparation deterrent on a data set has a 91 percent achievement rate on a data set. Consolidation of 500 realistic resolute and glaucoma retina images; hence, depending on the cluster, the computational advantage of In glaucoma therapy, the overlapping device pedestal on the machine learning algorithm has maximum output

Suppression of extreme events and chaos in a velocity-dependent potential system with time-delay feedback

The foremost aim of this study is to investigate the influence of time-delayed feedback on extreme events in a non-polynomial system with velocity dependent potential. To begin, we investigate the effect of this feedback on extreme events for four different values of the external forcing parameter. Among these four values, in the absence of time-delayed feedback, for two values, the system does not exhibit extreme events and for the other two values, the system exhibits extreme events. On the introduction of time-delayed feedback and varying the feedback strength, we found that extreme events get suppressed as well as get induced. When the feedback is positive, suppression occurs for a larger parameter region whereas in the case of negative feedback it is restricted to the limited parameter region. We confirm our results through Lyapunov exponents, probability density function of peaks, $d_{max}$ plot and two parameter probability plot. Finally, we analyze the changes in the overall dynamics of this system under the influence of time-delayed feedback. We notice that complete suppression of chaos occurs in the considered system for higher values of the time-delayed feedback.Comment: 28 pages, 16 figures, 1 table, Accepted for Publication Chaos, Solitons & Fractal

Estimation of an Object Trajectory in an Intake Duct using Numerical Simulation

This research aims to study the trajectory of an object inside a serpentine duct of a gas turbine engine using computational fluid dynamics. The coupled implicit solver with 6-degree of freedom (6-DOF) and chimera mesh (Overset mesh) is used to track the object’s trajectory. Various object orientation and aircraft angle of attack (AoA) at a speed of Mach 0.3 is studied. This provides an understanding of the bird’s movement inside the duct that might cause damage to the engine components during takeoff and landing. It was observed that the combination of AoA and object orientation decide the length of the trajectory before impact. The object is found to travel the farther when the AoA is at -20o with object oriented at 0o and 45o.The object tends pitch and yield to the flow irrespective of its initial orientation and hence the aircraft angle of attack is a more predominant factor. The effect of pressure recovery due to AoA and object orientation is also presented. The recovery is found to be at its best for AoA of 0o irrespective of object orientation. This approach could be utilised for designing an intake duct that can limit the damage to engine components due to bird ingestion and simultaneously maintain good pressure recovery

Acute and Protracted Cell Death in Light-Induced Retinal Degeneration in the Canine Model of Rhodopsin Autosomal Dominant Retinitis Pigmentosa

Purpose To characterize a light damage paradigm and establish structural and immunocytochemical measures of acute and protracted light-induced retinal degeneration in the rhodopsin (RHO) T4R dog model of RHO–autosomal dominant retinitis pigmentosa (ADRP). Methods Retinal light damage was induced in mutant dogs with a 1-minute exposure to various light intensities (0.1–1.0 mW/cm2) delivered with a Ganzfeld stimulator, or by fundus photography. Photoreceptor cell death was assessed by TUNEL assay, and alterations in retinal layers were examined by histology and immunohistochemistry 24 hours and 2 weeks after light exposure. Detailed topographic maps were made to document changes in the outer retinal layers of all four retinal quadrants 2 weeks post exposure. Results Twenty-four hours post light exposure, the severity of photoreceptor cell death was dose dependent. Immunohistochemical analysis revealed disruption of rod outer segments, focal loss of the RPE integrity, and an increase in expression of endothelin receptor B in Müller cells with the two highest doses of light and fundus photography. Two weeks after light exposure, persistence of photoreceptor death, thinning of the outer nuclear layer, and induction of Müller cell gliosis occurred with the highest doses of light. Conclusions We have characterized outcome measures of acute and continuing retinal degeneration in the RHO T4R dog following light exposure. These will be used to assess the molecular mechanisms of light-induced damage and rescue strategies in this large animal model of RHO-ADRP

What doesn't kill you makes you stranger: Dipeptidyl peptidase-4 (CD26) proteolysis differentially modulates the activity of many peptide hormones and cytokines generating novel cryptic bioactive ligands

Dipeptidyl peptidase 4 (DPP4) is an exopeptidase found either on cell surfaces where it is highly regulated in terms of its expression and surface availability (CD26) or in a free/circulating soluble constitutively available and intrinsically active form. It is responsible for proteolytic cleavage of many peptide substrates. In this review we discuss the idea that DPP4-cleaved peptides are not necessarily inactivated, but rather can possess either a modified receptor selectivity, modified bioactivity, new antagonistic activity, or even a novel activity relative to the intact parent ligand. We examine in detail five different major DPP4 substrates: glucagon-like peptide 1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP), peptide tyrosine-tyrosine (PYY), and neuropeptide Y (NPY), and stromal derived factor 1 (SDF-1 aka CXCL12). We note that discussion of the cleaved forms of these five peptides are underrepresented in the research literature, and are both poorly investigated and poorly understood, representing a serious research literature gap. We believe they are understudied and misinterpreted as inactive due to several factors. This includes lack of accurate and specific quantification methods, sample collection techniques that are inherently inaccurate and inappropriate, and a general perception that DPP4 cleavage inactivates its ligand substrates. Increasing evidence points towards many DPP4-cleaved ligands having their own bioactivity. For example, GLP-1 can work through a different receptor than GLP-1R, DPP4-cleaved GIP can function as a GIP receptor antagonist at high doses, and DPP4-cleaved PYY, NPY, and CXCL12 can have different receptor selectivity, or can bind novel, previously unrecognized receptors to their intact ligands, resulting in altered signaling and functionality. We believe that more rigorous research in this area could lead to a better understanding of DPP4’s role and the biological importance of the generation of novel cryptic ligands. This will also significantly impact our understanding of the clinical effects and side effects of DPP4-inhibitors as a class of anti-diabetic drugs that potentially have an expanding clinical relevance. This will be specifically relevant in targeting DPP4 substrate ligands involved in a variety of other major clinical acute and chronic injury/disease areas including inflammation, immunology, cardiology, stroke, musculoskeletal disease and injury, as well as cancer biology and tissue maintenance in aging

Atmospheric dispersion corrector for a multi-object spectroscopic mode of HROS-TMT

Highly multiplexed spectroscopic surveys have changed the astronomy landscape in recent years. However, these surveys are limited to low and medium spectral resolution. High spectral resolution spectroscopy is often photon starved and will benefit from a large telescope aperture. Multiplexed high-resolution surveys require a wide field of view and a large aperture for a suitable large number of bright targets. This requirement introduces several practical difficulties, especially for large telescopes, such as the future ELTs. Some of the challenges are the need for a wide field atmospheric dispersion corrector and to deal with the curved non-telecentric focal plane. Here, we present a concept of Multi-Object Spectroscopy (MOS) mode for TMT High-Resolution Optical Spectrograph (HROS), we have designed an atmospheric dispersion corrector for individual objects that fit inside a fiber positioner. We present the ZEMAX design and the performance of the atmospheric dispersion corrector for all elevations accessible by TMT