Antioxidant status in acute stroke patients and patients at stroke risk

Background and Purpose: Antioxidant enzymes like copper/ zinc superoxide dismutase (SOD), catalase and gluthatione peroxidase (GSHPx) are part of intracellular protection mechanisms to overcome oxidative stress and are known to be activated in vascular diseases and acute stroke. We investigated the differences of antioxidant capacity in acute stroke and stroke risk patients to elucidate whether the differences are a result of chronic low availability in arteriosclerosis and stroke risk or due to changes during acute infarction. Methods: Antioxidant enzymes were examined in 11 patients within the first hours and days after acute ischemic stroke and compared to risk- and age-matched patients with a history of stroke in the past 12 months ( n = 17). Antioxidant profile was determined by measurement of glutathione (GSH), malondialdehyde (MDA), SOD, GSHPx and minerals known to be involved in antioxidant enzyme activation like selenium, iron, copper and zinc. Results: In comparison to stroke risk patients, patients with acute ischemic stroke had significant changes of the GSH system during the first hours and days after the event: GSH was significantly elevated in the first hours (p < 0.01) and GSHPx was elevated 1 day after the acute stroke (p < 0.05). Selenium, a cofactor of GSHPx, was decreased (p < 0.01). GSHPx levels were negatively correlated with National Institutes of Health Stroke Scale (NIHSS) scores on admission (r = - 0.84, p < 0.001) and NIHSS scores after 7 days ( r = - 0.63, p < 0.05). MDA levels showed a trend for elevation in the first 6 h after the acute stroke ( p = 0.07). No significant differences of SOD, iron, copper nor zinc levels could be identified. Conclusions: Differences of antioxidant capacity were found for the GSH system with elevation of GSH and GSHPx after acute stroke, but not for other markers. The findings support the hypothesis that changes of antioxidant capacity are part of acute adaptive mechanisms during acute stroke. Copyright (C) 2004 S. Karger AG, Basel

The splintered art world of Contemporary Christian Music

...More than twenty years after CCM was begun, the Evangelical world still does not entirely trust rock music - Christian or otherwise - and in the context of this controversy CCM was born, has taken shape, and continues to evolve (Cusic 1990, p. 197). Consequently, out of the necessity to respond to the suspicions of the church (as well as the pressures of the rock music industry), the CCM art world has been forced to develop rationales for the acceptance of the rock idiom as a means for communicating a Christian message. While young fans have had to find rationales to justify their musical preferences to parents, pastors, and friends, it is the artist who has been most often expected to articulate these ration- ales. In addition to defending themselves from the attacks of their \u27Rock music is inherently evil\u27 opponents, artists also must justify their product to their record buying audience. John Styll (1993), editor of Contemporary Christian Music magazine, argues that it has been the audience which, from the beginning, has resisted the artists\u27 attempts to expand their range of subject matter beyond the gospel itself (p. 42). Hence, the artist must play the role of critic, as well as artist, in the CCM art world. Therefore, in our examination of the splintered art world of Contemporary Christian Music we pay particular attention to the rationales developed by artists, as well as those of the \u27pure\u27 critic..

Spatial and temporal variability of soil water content in two regions of Southwest German

Soil water content (SWC) plays a key role in partitioning of energy and water fluxes on the land surface. Knowledge about spatial and temporal variability of topsoil water content is crucial for understanding land surface processes, improving climate and hydrology modeling. In recent study, we investigated SWC variability, its relation to the mean spatial soil water content (qm) and variability of rainfall on the regional spatial and event temporal scales. To accomplish this, we used a multi-year high resolution data set, obtained from two soil moisture sensor networks (spatial extent of 25 km ×25 km), set up at croplands in Kraichgau and Swabian Alb regions in Southwest Germany. The relationship of SWC standard deviation (sq) versus áqñ was studied (sq-qm). It was found that the initial location of sq in relation to the sq at the permanent wilting point (sq-qwp) and the sq at saturation (sq-qs) – the anchor points – as well as the upper and lower bounds of the sq-qm envelope determine whether SWC variability increases or decreases upon a change in qm. sq-qm relationship forms combinations of concave and convex hyperbolas reflecting the variability of soil texture and depending on sq in relation to the anchor points. The majority of sq-qm clockwise hysteresis cases were observed in intermediate and intermediate/wet state of SWC. The sq phase-space can be used to test whether hydrological or land surface models capture the reasonable range of soil water heterogeneity

Climate readiness in smallholder agricultural systems: lessons learned from REDD+

The debate around the role that agriculture should play in mitigating climate change and sequestering greenhouse gases is politically complex and technically complicated. In many countries, and particularly in developing countries with a large smallholder population, the agricultural sector faces competing priorities, such as national food security goals, poverty alleviation, addressing natural resource degradation and adapting to the already visible effects of climate change. Many of these goals are closer to the immediate, short-term priorities of national decision-makers, relegating climate change mitigation to a secondary priority. It is therefore essential to implement mitigation strategies in concert with strategies that increase the resilience and increase the productivity of agricultural systems. Despite differences in the forestry and the agricultural sectors, experiences from the REDD+ process, and particularly its readiness phase, can offer useful lessons for an agricultural readiness process. The REDD+ readiness process created an overall coherent structure, framework and process of guiding countries towards developing the technical and institutional ability to integrate mitigation activities into their forestry sectors. An overview of the lessons learned from REDD+ Readiness, organized by objectives, governance, process, scope and finance, is provided in this working paper

Sünde

The article presents an overview of the concept of sin in Hittite culture by discussing the relevant texual sources, the terminology (was(a)-, wastul, haratar, idalu-, idalu- lala-, idalu uttar, idalu mema-, natta āra etc.) as well as the relating social and religious practices (e.g. means to detect sinful behaviour and to get rid of its consequences)Der Artikel bietet einen Überblick über den Sündenbegriff in der hethitischen Kultur, die relevanten Textquellen, die Terminologie sowie Verfahren zur Festellung und Beseitigung von Sünde und ihren Ursache

Seil und Schnur

The article presents an overview of the Hittite terms for strings, cords and similar objects (e.g. (kuš.)ishima, (kuš)ishiman(a)- (= sum. KU, akk. eblu), (síg.)pittula-, (síg.)suil-, síg.istagga(i)-, hanzana-, (uzu.)kapina-) their production and their various uses, esp. in Hittite magic and ritua