THE COMPENSATION MODEL OF PAYMENT FOR LABOR IN A SOCIALLY ORIENTED ECONOMY

The article examines compensation model of labor in today's market economy. This method of remuneration has a significant impact on the company's employees and increase the company's profits and profitability by compensating its employees. The idea of compensatory management arose in the context of a complex, increasingly competitive global economy in which all enterprises focused on the profitability and efficiency of their production. The formation of a system of rewarding workers based on their labor productivity level is a key factor that encourages the effective work accomplishments of the team

Acetazolamide to Prevent Adverse Altitude Effects in COPD and Healthy Adults

Background We evaluated the efficacy of acetazolamide in preventing adverse altitude effects in patients with moderate to severe chronic obstructive pulmonary disease (COPD) and in healthy lowlanders 40 years of age or older. Methods Trial 1 was a randomized, double-blind, parallel-design trial in which 176 patients with COPD were treated with acetazolamide capsules (375 mg/day) or placebo, starting 24 hours before staying for 2 days at 3100 m. The mean (±SD) age of participants was 57±9 years, and 34% were women. At 760 m, COPD patients had oxygen saturation measured by pulse oximetry of 92% or greater, arterial partial pressure of carbon dioxide less than 45 mm Hg, and mean forced expiratory volume in 1 second of 63±11% of predicted. The primary outcome in trial 1 was the incidence of the composite end point of altitude-related adverse health effects (ARAHE) at 3100 m. Criteria for ARAHE included acute mountain sickness (AMS) and symptoms or findings relevant to well-being and safety, such as severe hypoxemia, requiring intervention. Trial 2 comprised 345 healthy lowlanders. Their mean age was 53±7 years, and 69% were women. The participants in trial 2 underwent the same protocol as did the patients with COPD in trial 1. The primary outcome in trial 2 was the incidence of AMS assessed at 3100 m by the Lake Louise questionnaire score (the scale of self-assessed symptoms ranges from 0 to 15 points, indicating absent to severe, with 3 or more points including headache, indicating AMS). Results In trial 1 of patients with COPD, 68 of 90 (76%) receiving placebo and 42 of 86 (49%) receiving acetazolamide experienced ARAHE (hazard ratio, 0.54; 95% confidence interval [CI], 0.37 to 0.79; P<0.001). The number needed to treat (NNT) to prevent one case of ARAHE was 4 (95% CI, 3 to 8). In trial 2 of healthy individuals, 54 of 170 (32%) receiving placebo and 38 of 175 (22%) receiving acetazolamide experienced AMS (hazard ratio, 0.48; 95% CI, 0.29 to 0.80; chi-square statistic P=0.035). The NNT to prevent one case of AMS was 10 (95% CI, 5 to 141). No serious adverse events occurred in these trials. Conclusions Preventive treatment with acetazolamide reduced the incidence of adverse altitude effects requiring an intervention in patients with COPD and the incidence of AMS in healthy lowlanders 40 years of age or older during a high-altitude sojourn. (Funded by the Swiss National Science Foundation [Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung], Lunge Zürich, and the Swiss Lung Foundation; ClinicalTrials.gov numbers, NCT03156231 and NCT03561675.

Сравнительный анализ внешнего облучения различных профессиональных групп медперсонала г. Душанбе Республики Таджикистан

The work provides a comparative analysis of average annual individual radiation doses based on the obtained values of individual dose equivalent Hp (10), which had been obtained during 5 years of investigations (2014-2018) by using the thermo-luminescent dosimetry method of 70 employees working computed tomography, radioscopy, fluorography and radiography from 15 medical institutions in Dushanbe city. The ratio of medical personnel of the different professional groups showed that 63% of them were engaged in radiography, 19% x-ray, 10% computed tomography and 8% radioscopy. Analysis of the average annual radiation doses of every occupational group showed that the specialists in charge of fluorography have a high dose (max 1.74 mSv) and the personal of computed tomography have the lowest dose (max 1.34 mSv), and over time there is a tendency to equalize the values of average annual doses for all professional groups in the area close to the value of 1.5 mSv. The obtained data of the effective annual dose for all occupational categories had not exceeded the permissible dose limits values required by the «Radiation Safety Standards» (NRB-06 SP 2.6.1.001-06). Calculations are given without subtracting background values. The analysis data allows to identify the most exposed professional groups and to address the issues of ensuring radiation safety in a targeted manner.В работе на основе полученных величин индивидуального эквивалента дозы Hp(10) методом термолюминесцентной дозиметрии дается сравнительный анализ среднегодовых индивидуальных доз облучения за 5 лет (2014–2018 гг.) 70 сотрудников при проведении компьютерной томографии, скопии, флюорографии и рентгенографии из 15 медучреждений г. Душанбе. Соотношение медперсонала профессиональных групп показало, что 63% из них занимаются рентгенографией, 19% – флюорографией, 10% – компьютерной томографией и 8% – скопией. Анализ среднегодовых доз облучения каждой профессиональной группы показал, что наибольшую дозовую нагрузку в среднем имеют специалисты, занимающиеся флюорографией (max 1,74 мЗв), а наименьшую – компьютерной томографией (max 1,34 мЗв), причем со временем наблюдается тенденция выравнивания значений среднегодовых доз у всех профессиональных групп в область, близкую к значению 1,5 мЗв. Полученные данные эффективной годовой дозы для всех профессиональных категорий не превышают допустимые предельные значения, установленные «Нормами радиационной безопасности» (НРБ-06 СП 2.6.1.001-06). Расчеты даны без вычета фоновых значений. Данные анализа позволяют выявлять наиболее облучаемые профессиональные группы и целенаправленно решать вопросы обеспечения радиационной безопасности

Lime Cake as an Alternative Stabiliser for Loose Clayey Loams

Lime Cake (precipitated calcium carbonate PCC), a by-product of sugar production, is proposed as a stabiliser for improvement of loose silty clayey loams. Two inorganic pedogenic and organic precipitated calcium carbonate polymorphs are artificially synthesized into a base loosely compacted loamy soil. Formation, micromorphology, quality of cementing bonds, and physiochemical interactions in the interlayer are modelled at molecular level and verified by a suite of micro-analytical spectrometry techniques. Emphasis is put into determining the impacts of polysaccharides on soil strength and implications on soil pore anatomy. Erodibility, compressibility, volumetric change, and hydro-mechanical behaviour of base, and modified soils at yield and post-yield states are studied. Anomalies in suction-controlled post-yield stress–strain behaviour of modified soils are discussed and explained within the tenets of mechanics of composite soils with double porosity. PCC-reinforcement offers the closest possible packing at optimum water content. Desiccation cracking remains likely, but at relatively higher lower-bound water contents. Under low confinement levels and unsaturated state, strain-hardening prevails. Loss of shear strength on saturation is minimal. When saturated, PCC-reinforced soil develops substantially high levels of shear strength at all strain levels. Higher levels of confinement are needed for organic fibrous and onion-skin coating matters to effectively encrust the soil pore network; such high levels, however, leads to formation of an unwelcomed brittle, strain–softening stress–stress behaviour

Some indicators of lipid and phosphorus-calcium metabolism in children with rickitis receiving conventional treatment

In children with rickets and when rickets was aggravated by pneumonia and malnutrition, after the traditional method of treatment, there was no normalization of phosphorus-calcium metabolism and some indicators of lipid metabolism. Along with the clinical recovery, total blood and fecal lipids, SFA, and alkaline phosphatase activity remained elevated, while the content of calcium, phosphorus, and USEFA were below normal, which indicates an “incomplete recovery” and apparently requires further correction of biochemical parameters

Comparative analysis of the external exposure of different professional groups of medical staff of Dushanbe city of the Republic of Tajikistan

The work provides a comparative analysis of average annual individual radiation doses based on the obtained values of individual dose equivalent Hp (10), which had been obtained during 5 years of investigations (2014-2018) by using the thermo-luminescent dosimetry method of 70 employees working computed tomography, radioscopy, fluorography and radiography from 15 medical institutions in Dushanbe city. The ratio of medical personnel of the different professional groups showed that 63% of them were engaged in radiography, 19% x-ray, 10% computed tomography and 8% radioscopy. Analysis of the average annual radiation doses of every occupational group showed that the specialists in charge of fluorography have a high dose (max 1.74 mSv) and the personal of computed tomography have the lowest dose (max 1.34 mSv), and over time there is a tendency to equalize the values of average annual doses for all professional groups in the area close to the value of 1.5 mSv. The obtained data of the effective annual dose for all occupational categories had not exceeded the permissible dose limits values required by the «Radiation Safety Standards» (NRB-06 SP 2.6.1.001-06). Calculations are given without subtracting background values. The analysis data allows to identify the most exposed professional groups and to address the issues of ensuring radiation safety in a targeted manner

Theoretical Features and Usage of Phraseological Units in English Language

This article outlines the features of the use of figurative expressions while learning English. Onwards, there will be illustrated the followings definitions, categories of phraseological units, and their constituent parts, which are the most complex in meaning of language units

Exercise Performance in Central Asian Highlanders: A Cross-Sectional Study

Forrer, Aglaia, Philipp M. Scheiwiller, Maamed Mademilov, Mona Lichtblau, Ulan Sheraliev, Nuriddin H. Marazhapov, Stéphanie Saxer, Patrick Bader, Paula Appenzeller, Shoira Aydaralieva, Aybermet Muratbekova, Talant M. Sooronbaev, Silvia Ulrich, Konrad E. Bloch, and Michael Furian. Exercise performance in central Asian highlanders: A cross-sectional study. High Alt Med Biol. 22:386-394, 2021. Introduction: Life-long exposure to hypobaric hypoxia induces physiologic adaptations in highlanders that may modify exercise performance; however, reference data for altitude populations are scant. Methods: Life-long residents of the Tien Shan mountain range, 2,500 - 3,500 m, Kyrgyzstan, free of cardiopulmonary disease, underwent cardiopulmonary cycle exercise tests with a progressive ramp protocol to exhaustion at 3,250 m. ECG, breath-by-breath pulmonary gas exchange, and oxygen saturation by pulse oximetry (SpO2) were measured. Results: Among 81 highlanders, age (mean ± SD) 48 ± 10 years, 46% women, SpO2 at rest was 88% ± 2%, peak oxygen uptake (V'O2peak) was 21.6 ± 5.9 mL/kg/min (76% ± 15% predicted for a low-altitude reference population); peak work rate (Wpeak) was 117 ± 37 W (77% ± 17% predicted), SpO2 at peak was 84% ± 5%, heart rate reserve (220 - age - maximal heart rate) was 28 ± 17/min, ventilatory reserve (maximal voluntary ventilation - maximal minute ventilation) was 68 ± 32 l/min, and respiratory exchange ratio was 1.03 ± 0.09. Peak BORG-CR10 dyspnea and leg fatigue scores were 5.1 ± 2.0 and 6.3 ± 2.1. In multivariable linear regression analyses, age and sex were robust determinants of Wpeak, V'O2peak, and metabolic equivalent (MET) at peak, whereas body mass index, resting systolic blood pressure, and mean pulmonary artery pressure were not. Conclusions: The current study shows that V'O2peak and Wpeak of highlanders studied at 3,250 m, near their altitude of residence, were reduced by about one quarter compared with mean predicted values for lowlanders. The provided prediction models for V'O2peak, Wpeak, and METs in central Asian highlanders might be valuable for comparisons with other high altitude populations. Keywords: altitude; cardiopulmonary exercise test; high altitude pulmonary hypertension; hypoxia

Effect of High-Flow Oxygen on Exercise Performance in COPD Patients. Randomized Trial

Background: High-flow oxygen therapy (HFOT) provides oxygen-enriched, humidified, and heated air at high flow rates via nasal cannula. It could be an alternative to low-flow oxygen therapy (LFOT) which is commonly used by patients with chronic obstructive pulmonary disease (COPD) during exercise training. Research Question: We evaluated the hypothesis that HFOT improves exercise endurance in COPD patients compared to LFOT. Methods: Patients with stable COPD, FEV1 40–80% predicted, resting pulse oximetry (SpO2) ≥92%, performed two constant-load cycling exercise tests to exhaustion at 75% of maximal work rate on two different days, using LFOT (3 L/min) and HFOT (60 L/min, FiO2 0.45) in randomized order according to a crossover design. Primary outcome was exercise endurance time, further outcomes were SpO2, breath rate and dyspnea. Results: In 79 randomized patients, mean ± SD age 58 ± 9 y, FEV1 63 ± 9% predicted, GOLD grades 2-3, resting PaO2 9.4 ± 1.0 kPa, intention-to-treat analysis revealed an endurance time of 688 ± 463 s with LFOT and 773 ± 471 s with HFOT, mean difference 85 s (95% CI: 7 to 164, P = 0.034), relative increase of 13% (95% CI: 1 to 28). At isotime, patients had lower respiratory rate and higher SpO2 with HFOT. At end-exercise, SpO2 was higher by 2% (95% CI: 2 to 2), and Borg CR10 dyspnea scores were lower by 0.8 points (95% CI: 0.3 to 1.2) compared to LFOT. Interpretation: In mildly hypoxemic patients with COPD, HFOT improved endurance time in association with higher arterial oxygen saturation, reduced respiratory rate and less dyspnea compared to LFOT. Therefore, HFOT is promising for enhancing exercise performance in COPD. Clinical Trial Registration: www.ClinicalTrials.gov, identifier: NCT03955770

Effect of acetazolamide on visuomotor performance at high altitude in healthy people 40 years of age or older-RCT.

ObjectiveAltitude travel is increasingly popular also for middle-aged and older tourists and professionals. Due to the sensitivity of the central nervous system to hypoxia, altitude exposure may impair visuomotor performance although this has not been extensively studied. Therefore, we investigated whether a sojourn at moderately high altitude is associated with visuomotor performance impairments in healthy adults, 40y of age or older, and whether this adverse altitude-effect can be prevented by acetazolamide, a drug used to prevent acute mountain sickness.MethodsIn this randomized placebo-controlled parallel-design trial, 59 healthy lowlanders, aged 40-75y, were assigned to acetazolamide (375 mg/day, n = 34) or placebo (n = 25), administered one day before ascent and while staying at high altitude (3100m). Visuomotor performance was assessed at 760m and 3100m after arrival and in the next morning (post-sleep) by a computer-assisted test (Motor-Task-Manager). It quantified deviation of a participant-controlled cursor affected by rotation during target tracking. Primary outcome was the directional error during post-sleep recall of adaptation to rotation estimated by multilevel linear regression modeling. Additionally, adaptation, immediate recall, and correct test execution were evaluated.ResultsCompared to 760m, assessments at 3100m with placebo revealed a mean (95%CI) increase in directional error during adaptation and immediate recall by 1.9° (0.2 to 3.5, p = 0.024) and 1.1° (0.4 to 1.8, p = 0.002), respectively. Post-sleep recall remained unchanged (p = NS), however post-sleep correct test execution was 14% less likely (9 to 19, pConclusionIn healthy individuals, 40y of age or older, altitude exposure impaired adaptation to and immediate recall and correct execution of a visuomotor task. Preventive acetazolamide treatment improved visuomotor performance after one night at altitude and increased the probability of correct test execution compared to placebo.Clinicaltrials.gov identifierClinicalTrials.gov NCT03536520