Effects of nematic fluctuations on the elastic properties of iron arsenide superconductors

We demonstrate that the changes in the elastic properties of the FeAs systems, as seen in our resonant ultrasound spectroscopy data, can be naturally understood in terms of fluctuations of emerging nematic degrees of freedom. Both the softening of the lattice in the normal, tetragonal phase as well as its hardening in the superconducting phase are consistently described by our model. Our results confirm the view that structural order is induced by magnetic fluctuations.Comment: revised version with changed title accepted for publication in PR

Why pinning by surface irregularities can explain the peak effect in transport properties and neutron diffraction results in NbSe2 and Bi-2212 crystals?

The existence of a peak effect in transport properties (a maximum of the critical current as function of magnetic field) is a well-known but still intriguing feature of type II superconductors such as NbSe2 and Bi-2212. Using a model of pinning by surface irregularities in anisotropic superconductors, we have developed a calculation of the critical current which allows estimating quantitatively the critical current in both the high critical current phase and in the low critical current phase. The only adjustable parameter of this model is the angle of the vortices at the surface. The agreement between the measurements and the model is really very impressive. In this framework, the anomalous dynamical properties close to the peak effect is due to co-existence of two different vortex states with different critical currents. Recent neutron diffraction data in NbSe2 crystals in presence of transport current support this point of view

Improving agricultural efficiency with solar-powered tractors and magnetohydrodynamic entropy generation in copper–silver nanofluid flow

This study examines the impact of solar-powered tractor on agricultural productivity and energy efficiency. The implementation of solar energy in tractors has the potential to reduce dependence on non-renewable energy sources, minimize carbon emissions, and promote sustainable farming practices. This research investigates the reduction of energy consumption and enhancement of productivity by evaluating magnetohydrodynamic (MHD) entropy production through the flow of nanofluids containing copper-engine oil (Cu-EO) and silver-engine oil (Ag-EO). The study also evaluates the effectiveness of thermal transport in solar-powered tractors through several properties such as solar thermal radiation, viscous dissipation, slippery velocity, and porous media. The investigation analyzed the thermodynamics of entropy generation in a non-Newtonian Williamson nanofluid, with the aim of assessing its energy equilibrium and the effects of diverse physical parameters. In order to enable numerical investigation, similarity variables were implemented to transform partial differential equations into ordinary differential equations, and the Chebyshev collocation spectral method was applied to solve the governing equations. It has been revealed that the Williamson nanofluid have a smoother flow compared to the mixture fluid. Furthermore, Williamson-nanofluid demonstrate superior thermal conductivity and heat transfer characteristics compared to the base fluid, making them appropriate for utilization in cooling systems and heat exchangers in various industries. The boundary layer exhibits the maximum temperature while employing lamina-shaped particles, whilst the lowest temperature is shown when utilizing spherical-shaped nanoparticles. The Ag-EO nanofluid an efficiency rate of approximately 2.64 % with a minimum efficiency rate of 3.22 %. The findings will help develop eco-friendly agricultural methods that promote economic development while mitigating harm to the environment

The amyloid-beta degradation intermediate A beta 34 is pericyte-associated and reduced in brain capillaries of patients with Alzheimer's disease

An impairment of amyloid beta-peptide (A beta) clearance is suggested to play a key role in the pathogenesis of sporadic Alzheimer's disease (AD). Amyloid degradation is mediated by various mechanisms including fragmentation by enzymes like neprilysin, matrix metalloproteinases (MMPs) and a recently identified amyloidolytic activity of beta-site amyloid precursor protein cleaving enzyme 1 (BACE1). BACE1 cleavage of A beta 40 and A beta 42 results in the formation of a common A beta 34 intermediate which was found elevated in cerebrospinal fluid levels of patients at the earliest disease stages. To further investigate the role of A beta 34 as a marker for amyloid clearance in AD, we performed a systematic and comprehensive analysis of A beta 34 immunoreactivity in hippocampal and cortical post-mortem brain tissue from AD patients and non-demented elderly individuals. In early Braak stages, A beta 34 was predominantly detectable in a subset of brain capillaries associated with pericytes, while in later disease stages, in clinically diagnosed AD, this pericyte-associated A beta 34 immunoreactivity was largely lost. A beta 34 was also detected in isolated human cortical microvessels associated with brain pericytes and its levels correlated with A beta 40, but not with A beta 42 levels. Moreover, a significantly decreased A beta 34/A beta 40 ratio was observed in microvessels from AD patients in comparison to non-demented controls suggesting a reduced proteolytic degradation of A beta 40 to A beta 34 in AD. In line with the hypothesis that pericytes at the neurovascular unit are major producers of A beta 34, biochemical studies in cultured human primary pericytes revealed a time and dose dependent increase of A beta 34 levels upon treatment with recombinant A beta 40 peptides while A beta 34 production was impaired when A beta 40 uptake was reduced or BACE1 activity was inhibited. Collectively, our findings indicate that A beta 34 is generated by a novel BACE1-mediated A beta clearance pathway in pericytes of brain capillaries. As amyloid clearance is significantly reduced in AD, impairment of this pathway might be a major driver of the pathogenesis in sporadic AD

Characterisation of Campylobacter spp. Isolated from Poultry in KwaZulu-Natal, South Africa

This study investigated the antibiotic resistance, virulence profiles, and clonality of Campylobacter jejuni and Campylobacter coli isolated from an intensive poultry farming system in KwaZulu-Natal, South Africa. Following ethical approval, samples were collected over six weeks using the farm-to-fork approach. Campylobacter spp. were identified using culture, confirmed and differentiated to species level by PCR, and subjected to antibiotic susceptibility testing. Selected antibiotic resistance (and mutations) and virulence genes were screened by PCR and confirmed by DNA sequencing. Genetic relatedness amongst the isolates was ascertained using pulsed-field gel electrophoresis. In all, 105 isolates were confirmed as belonging to both Campylobacter coli (60; 57%) and C. jejuni (45; 43%). The highest resistance was recorded against erythromycin and clindamycin. The gyrA mutation, A20175C/A2074G point mutation, tet(O), and cmeB, all associated with antibiotic resistance, were detected. All the virulence genes (pldA, ciaB, cdtA, cdtB, cdtC, dnaJ, except for cadF) were also detected. Isolates were grouped into five pulsotypes displaying 85% similarity, irrespective of their resistance profiles. The numerous permutations of clonality, antibiotic resistance, and virulence profiles evident in Campylobacter spp. pose a challenge to food safety and necessitate a comprehensive understanding of the molecular epidemiology of this organism to decrease its spread in the food chain

Aβ34 is a BACE1-derived degradation intermediate associated with amyloid clearance and Alzheimer’s disease progression

The beta-site APP cleaving enzyme 1 (BACE1) is known primarily for its initial cleavage of the amyloid precursor protein (APP), which ultimately leads to the generation of Aβ peptides. Here, we provide evidence that altered BACE1 levels and activity impact the degradation of Aβ40 and Aβ42 into a common Aβ34 intermediate. Using human cerebrospinal fluid (CSF) samples from the Amsterdam Dementia Cohort, we show that Aβ34 is elevated in individuals with mild cognitive impairment who later progressed to dementia. Furthermore, Aβ34 levels correlate with the overall Aβ clearance rates in amyloid positive individuals. Using CSF samples from the PREVENT-AD cohort (cognitively normal individuals at risk for Alzheimer’s disease), we further demonstrate that the Aβ34/Aβ42 ratio, representing Aβ degradation and cortical deposition, associates with pre-clinical markers of neurodegeneration. We propose that Aβ34 represents a marker of amyloid clearance and may be helpful for the characterization of Aβ turnover in clinical samples